{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:52:47Z","timestamp":1791355967226,"version":"4.3.1"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Although carotid atherosclerosis is a recognized risk factor, the relationship between plaque characteristics and clinical outcomes after cardiac surgery remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We retrospectively studied 1087 patients undergoing coronary artery bypass graft\u2010containing cardiac surgery between January 2023 and January 2024. Preoperative carotid ultrasound was used to assign Carotid Plaque\u2010Reporting and Data System (Plaque\u2010RADS) grades 1 to 4. The primary outcome was in\u2010hospital ischemic stroke. Given the low number of events, associations were evaluated using Firth penalized logistic regression with limited covariate adjustment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In\u2010hospital ischemic stroke occurred in 14 patients (1.3%). Stroke incidence increased across Plaque\u2010\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">RADS<\/jats:styled-content>\n                      grades from 0% in grade 1 to 0.6%, 2.0%, and 6.3% in grades 2, 3, and 4, respectively (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.011). Higher Plaque\u2010\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">RADS<\/jats:styled-content>\n                      grade was associated with greater odds of in\u2010hospital ischemic stroke after adjustment for age, sex, surgical procedure, operative time, and aortic atherosclerotic burden (\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">odds ratio<\/jats:styled-content>\n                      per 1\u2010grade increase, 4.31 [95%\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">CI<\/jats:styled-content>\n                      , 1.72\u201311.43];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.002). The association was directionally similar among patients with carotid stenosis &lt;50%. In exploratory discrimination analyses, the model including both stenosis and Plaque\u2010\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">RADS<\/jats:styled-content>\n                      had the highest numerical\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">area under the receiver operating characteristic curve<\/jats:styled-content>\n                      , although the incremental gain over either individual parameter was modest.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Higher ultrasound\u2010based Plaque\u2010RADS grade was associated with in\u2010hospital ischemic stroke after coronary artery bypass graft\u2010containing cardiac surgery. Plaque\u2010RADS may provide complementary risk information. These findings should be considered hypothesis generating and require validation in larger prospective cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.051562","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:15:50Z","timestamp":1790680550000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Carotid Plaque\u2010Reporting and Data System for Predicting In\u2010Hospital Ischemic Stroke After Coronary Artery Bypass Graft\u2010Containing Cardiac Surgery: Complementary Value Beyond Stenosis Severity"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0648-0013","authenticated-orcid":false,"given":"Yingjian","family":"Pei","sequence":"first","affiliation":[{"name":"Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0337-705X","authenticated-orcid":false,"given":"Guitao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Li","sequence":"additional","affiliation":[{"name":"Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7215-3987","authenticated-orcid":false,"given":"Yinghua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4740-9615","authenticated-orcid":false,"given":"Shujuan","family":"Li","sequence":"additional","affiliation":[{"name":"Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, 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