{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:38:30Z","timestamp":1792647510530,"version":"4.5.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study sought to determine the impact of left ventricular size on clinical outcomes after a microaxial flow pump was surgically implanted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this retrospective cohort study, we included patients who received a surgical microaxial left ventricular assist device from May 2020 to February 2024 at 2 high\u2010volume centers in the United States. Patients were categorized into 2 groups based on their preimplant left ventricular end\u2010diastolic diameter (LVEDD): \u201csmall LVEDD,\u201d defined as LVEDD \u22645.5 cm, and \u201clarge LVEDD,\u201d defined as LVEDD &gt;5.5 cm, respectively. End points were all\u2010cause death at 30\u2009days after device implantation, in\u2010hospital death, death 30\u2010days after discharge, and survival at 30\u2010month follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Two\u2010hundred sixty\u2010two patients received an Impella 5.5. Preimplant LVEDD was documented in 194 (74%) patients, where 50 patients had LVEDD \u22645.5 cm and 144 patients had LVEDD &gt;5.5 cm. Patients with a small LVEDD had a higher rate of all\u2010cause death at 30\u2009days after device implantation (32% versus 11.8%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.002), in\u2010hospital death (42% versus 20.1%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.004), and death 30\u2009days after discharge (44% versus 20.8%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.003). In adjusted analyses, patients with a greater LVEDD had 62% decreased risk of long\u2010term death (hazard ratio, 0.39 [95% CI, 0.19\u20130.76];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.001), compared with patients with a smaller LVEDD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this real\u2010world, all\u2010comer study, we found that patients with reduced left ventricular dimension who required an Impella 5.5 had worse outcomes. Further research is warranted to recapitulate our observations across more centers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.051803","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:56:24Z","timestamp":1791633384000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Left Ventricular End\u2010Diastolic Diameter Predicts Clinical Outcomes in Patients Supported With Surgically Implanted Microaxial Flow Pump"],"prefix":"10.1161","volume":"15","author":[{"given":"Ali","family":"Fatehi Hassanabad","sequence":"first","affiliation":[{"name":"Columbia University Medical Center, New York Presbyterian Hospital","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, New York Presbyterian Hospital","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph G.","family":"Barile","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, New York Presbyterian Hospital","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2938-571X","authenticated-orcid":false,"given":"Yuichiro","family":"Kitada","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, New York Presbyterian Hospital","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Dardik","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, New York Presbyterian Hospital","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6146-2637","authenticated-orcid":false,"given":"Justin","family":"Fried","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, New York Presbyterian Hospital","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8071-6625","authenticated-orcid":false,"given":"Mauer","family":"Biscotti","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania","place":["Philadelphia, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8008-7526","authenticated-orcid":false,"given":"Michael V.","family":"Genuardi","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine","place":["Philadelphia, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5559-8033","authenticated-orcid":false,"given":"Marisa","family":"Cevasco","sequence":"additional","affiliation":[{"name":"Hospital of the University of Pennsylvania","place":["Philadelphia, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8263-1911","authenticated-orcid":false,"given":"Koji","family":"Takeda","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, New York Presbyterian Hospital","place":["New York, 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