{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:38:56Z","timestamp":1792647536385,"version":"4.5.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Left atrial (LA) enlargement has been proposed to increase stroke risk independent of atrial fibrillation (AF), but evidence accounting for AF over time is limited. We tested whether the association between LA enlargement and stroke persist independent of new\u2010onset AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this observational study, participants from the Copenhagen General Population Study underwent cardiac computed tomography from 2010 through 2018 and were followed until December 2022. LA volume was indexed to body surface area. LA enlargement was defined using sex\u2010specific cutoffs. The primary outcome was incident stroke. Secondary outcomes were incident AF, heart failure, dementia, and all\u2010cause mortality. Individuals with baseline AF were excluded. Hazard ratios (HRs) were estimated using cause\u2010specific Cox models with AF modeled as a time\u2010varying covariate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 10\u2009024 individuals (mean age 60\u2009years, 57% women), 684 (6.8%) had LA enlargement. Over a median follow\u2010up of 7.3\u2009years stroke occurred in 356 individuals (3.6%). LA enlargement was associated with a higher absolute risk of stroke (11.1% versus 4.6%, risk difference 6.5% [95% CI, 2.4\u201310.6]) and an increased hazard (adjusted HR, 1.49 [95% CI, 1.09\u20132.05];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.013), which remained similar after adjustment for incident AF, and in separate\u00a0models using the CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      \u2010VA score and P\u2010wave terminal force in lead V1. LA enlargement was also associated with higher risk of AF (HR, 3.77 [95% CI, 3.00\u20134.73]) and heart failure (HR, 3.59 [95% CI, 2.54\u20135.06]) but not with dementia or all\u2010cause mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">LA enlargement was associated with incident stroke independent of incident AF, supporting LA enlargement as a marker of thromboembolic risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.053248","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:04:31Z","timestamp":1791633871000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Left Atrial Enlargement Identifies Risk of Stroke Independent of Atrial Fibrillation"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9496-7655","authenticated-orcid":false,"given":"Jonas J.","family":"Loft","sequence":"first","affiliation":[{"name":"Copenhagen University Hospital \u2013 Rigshospitalet","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen T.","family":"K\u00fchl","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital \u2013 Rigshospitalet","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6577-0079","authenticated-orcid":false,"given":"Michael H. C.","family":"Pham","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital \u2013 Rigshospitalet","place":["Denmark"]},{"name":"Copenhagen University Hospital \u2013 Rigshospitalet","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per E.","family":"Sigvardsen","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital \u2013 Rigshospitalet","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0236-0811","authenticated-orcid":false,"given":"Andreas F.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital \u2013 Amager and Hvidovre","place":["Hvidovre, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1954-7220","authenticated-orcid":false,"given":"B\u00f8rge G.","family":"Nordestgaard","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital \u2013 Herlev and Gentofte Hospital","place":["Herlev, Denmark"]},{"name":"University of Copenhagen","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-1466","authenticated-orcid":false,"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital \u2013 Rigshospitalet","place":["Denmark"]},{"name":"Copenhagen University Hospital \u2013 Herlev and Gentofte Hospital","place":["Herlev, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0002-1645","authenticated-orcid":false,"given":"Mathias","family":"Lowes","sequence":"additional","affiliation":[{"name":"Technical University of Denmark","place":["Kongens Lyngby, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0647-3215","authenticated-orcid":false,"given":"Rasmus R.","family":"Paulsen","sequence":"additional","affiliation":[{"name":"Technical University of Denmark","place":["Kongens Lyngby, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9742-1554","authenticated-orcid":false,"given":"Klaus F.","family":"Kofoed","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital \u2013 Rigshospitalet","place":["Denmark"]},{"name":"Copenhagen University Hospital \u2013 Rigshospitalet","place":["Denmark"]},{"name":"University of Copenhagen","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.02.048"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euae204"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001193"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-026-01266-y"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp2415601"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.3782"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.04.031"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.04.068"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.119.009746"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.047747"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.012004"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.4.835"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.10.2019"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.4065\/79.8.1008"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.091688"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev337"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32233-9"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/M22-3027"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/14017431.2012.673728"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000107084"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000102143"},{"key":"e_1_3_2_23_2","article-title":"The validity of the diagnosis of heart failure (I50.0\u2013I50.9) in the Danish National Patient Register","volume":"65","author":"Delekta J","year":"2018","unstructured":"Delekta J, Hansen SM, AlZuhairi KS, Bork CS, Joensen AM. 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