{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:21:18Z","timestamp":1787862078747,"version":"build-2784847793"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p><jats:bold><jats:italic>Background and Purpose\u2014<\/jats:italic><\/jats:bold>Stroke is a major risk factor for hip fracture. Patients with intermediate rather than severe or mild stroke deficits at the time of hospital discharge have the most fractures. This proof-of-concept study evaluated the efficacy of a single infusion of zoledronate, an intravenous bisphosphonate, in preserving hip bone density after stroke.<\/jats:p><jats:p><jats:bold><jats:italic>Methods\u2014<\/jats:italic><\/jats:bold>In a 1-year randomized, double-blind, placebo-controlled, clinical trial, 27 newly hemiplegic patients (6 females, 21 males) with acute stroke were assigned to receive 4 mg of the intravenous zoledronate (n=14) or placebo (n=13) within 35 days. Strict inclusion criteria were followed-up to ensure recruited patients were likely to have residual functional impairment. Both groups received calcium and vitamin D supplementation. The primary outcome measure was the change in bone mineral density (BMD; Lunar Prodigy) at the hemiplegic hip during the year of investigation.<\/jats:p><jats:p><jats:bold><jats:italic>Results\u2014<\/jats:italic><\/jats:bold>The treatment was generally well tolerated. Mean total hip BMD was unchanged in the hemiplegic hip of the zoledronate group (mean 0.0% change), whereas in the placebo group the total hip BMD changed by \u22125.5%, with the greatest bone loss observed in the trochanteric subregion (mean, \u22128.1%). On the unaffected side the mean change in total hip BMD was +1.0% with zoledronate versus a mean change of \u22122.7% without. Repeated measures ANOVA confirmed the significance of the differences between groups at both hips (hemiplegic,<jats:italic>P<\/jats:italic>&lt;0.001; unaffected,<jats:italic>P<\/jats:italic>=0.002).<\/jats:p><jats:p><jats:bold><jats:italic>Conclusions\u2014<\/jats:italic><\/jats:bold>Stroke patients were protected from the deleterious effects of hemiplegia on hip bone density for at least 1 year after a single infusion of zoledronate.<\/jats:p>","DOI":"10.1161\/strokeaha.106.474262","type":"journal-article","created":{"date-parts":[[2007,3,30]],"date-time":"2007-03-30T01:21:52Z","timestamp":1175217712000},"page":"1519-1525","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":48,"title":["A Single Infusion of Zoledronate Prevents Bone Loss After Stroke"],"prefix":"10.1161","volume":"38","author":[{"given":"Kenneth E.S.","family":"Poole","sequence":"first","affiliation":[{"name":"From Division of Bone Research (K.E.S.P., N.L., C.M.R., J.R.) and Department of Clinical Neurosciences (E.A.W.), Department of Medicine, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, England."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Loveridge","sequence":"additional","affiliation":[{"name":"From Division of Bone Research (K.E.S.P., N.L., C.M.R., J.R.) and Department of Clinical Neurosciences (E.A.W.), Department of Medicine, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, England."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Collette M.","family":"Rose","sequence":"additional","affiliation":[{"name":"From Division of Bone Research (K.E.S.P., N.L., C.M.R., J.R.) and Department of Clinical Neurosciences (E.A.W.), Department of Medicine, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, England."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Warburton","sequence":"additional","affiliation":[{"name":"From Division of Bone Research (K.E.S.P., N.L., C.M.R., J.R.) and Department of Clinical Neurosciences (E.A.W.), Department of Medicine, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, England."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Reeve","sequence":"additional","affiliation":[{"name":"From Division of Bone Research (K.E.S.P., N.L., C.M.R., J.R.) and Department of Clinical Neurosciences (E.A.W.), Department of Medicine, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, England."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.32.3.702"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0020-1383(92)90171-N"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050053"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980170028"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2006.00769.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050147"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070103"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00374-4"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002060-199308000-00003"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000152871.65027.76"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.15.1743"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000016094"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00298-7"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011807"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000014510.48897.7d"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.65.9.1513"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.11.1373"},{"key":"e_1_3_2_18_2","first-page":"56","volume":"14","year":"1965","unstructured":"Mahoney F, Barthel D. 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