{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T04:48:24Z","timestamp":1777092504003,"version":"3.51.4"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Abnormalities in neurocognitive function are common after surgery for aneurysmal subarachnoid hemorrhage, even among patients with good functional outcomes. The time course of neurocognitive recovery, along with the long-term effects of mild intraoperative hypothermia (33\u00b0C) and aneurysm location, is unknown. We determined these in a subset of subarachnoid hemorrhage patients enrolled in the Intraoperative Hypothermia for Aneurysm Surgery Trial (IHAST).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            We performed a longitudinal, multicenter, prospective, blinded study of adult IHAST patients with a Glasgow Outcome Score=1 or 2 (independent function), 3 months postsurgery and a matched control group (n=45). Subjects were tested with a 5-test cognitive function battery and standard neurological evaluations at 3, 9 and 15 months postsurgery. The primary outcome measure was a composite score on cognitive test performance.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            There were 303 IHAST patients available for inclusion: 218 eligible, 185 enrolled (89 hypothermic, 96 normothermic). Significant cognitive improvement was noted from 3 to 9 (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) and 3 to 15 (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001) months in both hypothermic and normothermic groups, even after adjusting for practice effects observed in the control group. No significant change was identified between 9 and 15 months. Neither mild hypothermia nor aneurysm location (anterior communicating artery versus others) had a significant effect on recovery over time or frequency of cognitive impairment. Compared with control group, the frequency of cognitive impairment (\n            <jats:italic>Z<\/jats:italic>\n            score &lt;\u22121.96) in all patients at 3, 9 and 15 months was 36%, 26% and 23%, respectively.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            In this population, cognitive improvement continued beyond 3 months, with a plateau between 9 and 15 months. This was not affected by the use of intraoperative hypothermia or anatomical location of aneurysm.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.106.477448","type":"journal-article","created":{"date-parts":[[2007,4,13]],"date-time":"2007-04-13T00:53:22Z","timestamp":1176425602000},"page":"1864-1872","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":76,"title":["Recovery of Cognitive Function After Surgery for Aneurysmal Subarachnoid Hemorrhage"],"prefix":"10.1161","volume":"38","author":[{"given":"Satwant K.","family":"Samra","sequence":"first","affiliation":[{"name":"From the Department of Anesthesiology (S.K.S.), University of Michigan Medical Center, Ann Arbor; the Department of Psychiatry (B.G., A.F.C.), University of Michigan Medical Center, Ann Arbor; the Department of Biostatistics and Clinical Trials Data Management Center in the College of Public Health (W.R.C.), University of Iowa Carver College of Medicine, Iowa City; Department of Emergency Medicine (P.A.S.), University of Michigan Medical Center, Ann Arbor; the Department of Neurology (S.A.),..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Giordani","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology (S.K.S.), University of Michigan Medical Center, Ann Arbor; the Department of Psychiatry (B.G., A.F.C.), University of Michigan Medical Center, Ann Arbor; the Department of Biostatistics and Clinical Trials Data Management Center in the College of Public Health (W.R.C.), University of Iowa Carver College of Medicine, Iowa City; Department of Emergency Medicine (P.A.S.), University of Michigan Medical Center, Ann Arbor; the Department of Neurology (S.A.),..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela F.","family":"Caveney","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology (S.K.S.), University of Michigan Medical Center, Ann Arbor; the Department of Psychiatry (B.G., A.F.C.), University of Michigan Medical Center, Ann Arbor; the Department of Biostatistics and Clinical Trials Data Management Center in the College of Public Health (W.R.C.), University of Iowa Carver College of Medicine, Iowa City; Department of Emergency Medicine (P.A.S.), University of Michigan Medical Center, Ann Arbor; the Department of Neurology (S.A.),..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Clarke","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology (S.K.S.), University of Michigan Medical Center, Ann Arbor; the Department of Psychiatry (B.G., A.F.C.), University of Michigan Medical Center, Ann Arbor; the Department of Biostatistics and Clinical Trials Data Management Center in the College of Public Health (W.R.C.), University of Iowa Carver College of Medicine, Iowa City; Department of Emergency Medicine (P.A.S.), University of Michigan Medical Center, Ann Arbor; the Department of Neurology (S.A.),..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip A.","family":"Scott","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology (S.K.S.), University of Michigan Medical Center, Ann Arbor; the Department of Psychiatry (B.G., A.F.C.), University of Michigan Medical Center, Ann Arbor; the Department of Biostatistics and Clinical Trials Data Management Center in the College of Public Health (W.R.C.), University of Iowa Carver College of Medicine, Iowa City; Department of Emergency Medicine (P.A.S.), University of Michigan Medical Center, Ann Arbor; the Department of Neurology (S.A.),..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Anderson","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology (S.K.S.), University of Michigan Medical Center, Ann Arbor; the Department of Psychiatry (B.G., A.F.C.), University of Michigan Medical Center, Ann Arbor; the Department of Biostatistics and Clinical Trials Data Management Center in the College of Public Health (W.R.C.), University of Iowa Carver College of Medicine, Iowa City; Department of Emergency Medicine (P.A.S.), University of Michigan Medical Center, Ann Arbor; the Department of Neurology (S.A.),..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byron G.","family":"Thompson","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology (S.K.S.), University of Michigan Medical Center, Ann Arbor; the Department of Psychiatry (B.G., A.F.C.), University of Michigan Medical Center, Ann Arbor; the Department of Biostatistics and Clinical Trials Data Management Center in the College of Public Health (W.R.C.), University of Iowa Carver College of Medicine, Iowa City; Department of Emergency Medicine (P.A.S.), University of Michigan Medical Center, Ann Arbor; the Department of Neurology (S.A.),..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"Todd","sequence":"additional","affiliation":[{"name":"From the Department of Anesthesiology (S.K.S.), University of Michigan Medical Center, Ann Arbor; the Department of Psychiatry (B.G., A.F.C.), University of Michigan Medical Center, Ann Arbor; the Department of Biostatistics and Clinical Trials Data Management Center in the College of Public Health (W.R.C.), University of Iowa Carver College of Medicine, Iowa City; Department of Emergency Medicine (P.A.S.), University of Michigan Medical Center, Ann Arbor; the Department of Neurology (S.A.),..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","first-page":"999","volume":"33","year":"1993","unstructured":"Hutter B, Gilsbach J. Which neuropsychological deficits are hitdden behind a good outcome (Glasgow = 1) after aneurysmal subarachnoid hemorrhage? Neurosurgery. 1993; 33: 999\u20131005.","journal-title":"Neurosurgery"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/02688699550041106"},{"key":"e_1_3_3_3_2","first-page":"157","volume":"72","year":"1999","unstructured":"Hutter B, Kreitschmann-Andermahr I, Mayfrank L, Rohde V, Spetzger U, Gilsbach J. Functional outcome after aneurysmal subarachnoid hemorrhage. Acta Neurochirurgica - (Supplement). 1999; 72: 157\u2013174.","journal-title":"Acta Neurochirurgica - (Supplement)"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040975"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21018"},{"key":"e_1_3_3_6_2","unstructured":"Benton AL. The Revised Visual Retention Test: Clinical and Experimental Applications 4th ed. New York: Psychological Corp. 1974: 1\u201392."},{"key":"e_1_3_3_7_2","unstructured":"Benton AL Hamsher KDS. Multilingual aphasia examination. Iowa City IA: AJA Associates Inc; 1994."},{"key":"e_1_3_3_8_2","unstructured":"Lezak M. Neuropsychological Assessment. Oxford University Press New York; 1995: 475\u2013480."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(78)80049-5"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/13854048908403285"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1207\/s15327752jpa6703_13"},{"key":"e_1_3_3_12_2","first-page":"127","volume":"1998","year":"1998","unstructured":"Steer R, Kumar G, Ranieri W, Beck A. Use of the depression inventory-II with adolescent psychiatric outpatients. Journal of Psychopathology and Behavioral Assessment. 1998; 1998: 127\u2013136.","journal-title":"Journal of Psychopathology and Behavioral Assessment"},{"key":"e_1_3_3_13_2","unstructured":"Deleted in proof."},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","unstructured":"Sivan AB. The Benton Visual Retention Test 5th edition. San Antonio Texas: The Psychological Corporation; 1992.","DOI":"10.1037\/t14985-000"},{"key":"e_1_3_3_15_2","unstructured":"Benton AL Hamsher K Sivan AB. The Multilingual Aphasia Examination. Iowa City Iowa: AJA Associates Inc; 1994."},{"key":"e_1_3_3_16_2","unstructured":"Deleted in proof."},{"key":"e_1_3_3_17_2","unstructured":"Heaton RK Grant I Matthews CG. Comprehensive Norms for an Expanded Halstead-Reitan Battery: Demographic Corrections Research Findings and Clinical Applications. Odessa Florida: Psychological Assessment Resources; 1991."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2001.045003275.x"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/hup.624"},{"key":"e_1_3_3_20_2","doi-asserted-by":"crossref","unstructured":"Davis Charles S. Statistical Methods for the Analysis of Repeated Measurements. New York: Springer-Verlag; 2002.","DOI":"10.1007\/b97287"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198711000-00008"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(89)80042-5"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.62.5.0673"},{"key":"e_1_3_3_24_2","first-page":"260","volume":"3","year":"1990","unstructured":"Ogden JA, Levin PL, Mee EW. Long-term neuropsychological and psychosocial effects of subarachnoid hemorrhage. Neuropsychiatry Neuropsychol Behav Neurol. 1990; 3: 260\u2013274.","journal-title":"Neuropsychiatry Neuropsychol Behav Neurol"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2626(88)90032-2"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.54.10.909"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1991.tb04659.x"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.52.10.1135"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198908000-00003"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.65.1.93"},{"key":"e_1_3_3_31_2","first-page":"572","volume":"33","year":"1993","unstructured":"Ogden JA, Mee EW, Henning M. A prospective study of impairment of cognition and memory and recovery after subarachnoid hemorrhage. Neurosurgery. 1993; 33: 572\u2013587.","journal-title":"Neurosurgery"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1207\/S15324826AN1003_04"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.15.3.333"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1037\/0894-4105.7.3.273"},{"key":"e_1_3_3_35_2","first-page":"495","volume":"15","year":"2000","unstructured":"Ardila A, Ostrosky-Solis F, Rosselli M, Gomez C. Age-related cognitive decline during normal aging: the complex effect of education. Arch Clin Neuropsychol. 2000; 15: 495\u2013513.","journal-title":"Arch Clin Neuropsychol"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20637"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.106.477448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:23:15Z","timestamp":1715602995000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.106.477448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1161\/STROKEAHA.106.477448"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.106.477448","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]},"assertion":[{"value":"2006-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-01-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-04-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}