{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:38:29Z","timestamp":1792157909994,"version":"4.4.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>Background and Purpose\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Patent foramen ovale (PFO) has been identified as a potential risk factor for cerebrovascular ischemia. Procoagulant mutations may increase the risk and impact the choice of appropriate therapy for secondary prevention. We evaluated the prevalence of the 2 most common genetic risk factors for thromboembolism, factor V Leiden (G1691A) and prothrombin G20210A, in young PFO patients who were referred for percutaneous transcatheter closure of their PFO.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Ninety-seven patients (50 men; mean\u00b1SD age, 40.9\u00b110.0 years) with first-ever cerebrovascular events before the age of 55 years and 160 age-matched control subjects (69 men; mean\u00b1SD age, 40.4\u00b110.5 years) were recruited into the study. Factor V Leiden and prothrombin G20210A mutations were detected by using a multiplex allele-specific polymerase chain reaction assay.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Results\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    The prevalence of subjects carrying at least 1 prothrombotic genotype was significantly higher in the group of PFO patients than in the group of controls (10.3% vs 2.5%; \u03c7\n                    <jats:sup>2<\/jats:sup>\n                    =7.2,\n                    <jats:italic>P<\/jats:italic>\n                    =0.008). Two patients (2.1%) versus 1 control subject (0.6%) and 8 cases (8.2%) versus 3 controls (1.9%) were carriers for factor V Leiden and prothrombin G20210A mutations, respectively. After adjustment for other vascular risk factors, the combination of either factor V Leiden or prothrombin G20210A and PFO was associated with a 4.7-fold (95% CI=1.4 to 16.1;\n                    <jats:italic>P<\/jats:italic>\n                    =0.008) increased risk of cerebral ischemia in young patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusions\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Our results indicate that prothrombotic mutations are important risk factors for cerebral ischemia in young patients with PFO. Screening for thrombotic mutations should be considered in young patients with PFO-related ischemic events.\n                  <\/jats:p>","DOI":"10.1161\/strokeaha.106.480863","type":"journal-article","created":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T06:55:55Z","timestamp":1180076155000},"page":"2070-2073","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":78,"title":["Prothrombotic Mutations as Risk Factors for Cryptogenic Ischemic Cerebrovascular Events in Young Subjects With Patent Foramen Ovale"],"prefix":"10.1161","volume":"38","author":[{"given":"Nicoletta","family":"Botto","sequence":"first","affiliation":[{"name":"From the CNR Institute of Clinical Physiology (N.B., I.S., S.G., L.A.-A., M.G.A.), G. Pasquinucci Hospital, Massa, and the CNR Institute of Clinical Physiology (R.S.), Pisa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Spadoni","sequence":"additional","affiliation":[{"name":"From the CNR Institute of Clinical Physiology (N.B., I.S., S.G., L.A.-A., M.G.A.), G. Pasquinucci Hospital, Massa, and the CNR Institute of Clinical Physiology (R.S.), Pisa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Giusti","sequence":"additional","affiliation":[{"name":"From the CNR Institute of Clinical Physiology (N.B., I.S., S.G., L.A.-A., M.G.A.), G. Pasquinucci Hospital, Massa, and the CNR Institute of Clinical Physiology (R.S.), Pisa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Ait-Ali","sequence":"additional","affiliation":[{"name":"From the CNR Institute of Clinical Physiology (N.B., I.S., S.G., L.A.-A., M.G.A.), G. Pasquinucci Hospital, Massa, and the CNR Institute of Clinical Physiology (R.S.), Pisa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Sicari","sequence":"additional","affiliation":[{"name":"From the CNR Institute of Clinical Physiology (N.B., I.S., S.G., L.A.-A., M.G.A.), G. Pasquinucci Hospital, Massa, and the CNR Institute of Clinical Physiology (R.S.), Pisa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Andreassi","sequence":"additional","affiliation":[{"name":"From the CNR Institute of Clinical Physiology (N.B., I.S., S.G., L.A.-A., M.G.A.), G. Pasquinucci Hospital, Massa, and the CNR Institute of Clinical Physiology (R.S.), Pisa, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)60336-X"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198805053181802"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.9.950"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.08.038"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.24.1.8418547"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(10)80354-7"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.31.2.398"},{"key":"e_1_3_2_8_2","first-page":"1095","volume":"87","year":"2002","unstructured":"De Stefano V, Rossi E, Paciaroni K, Leone G. 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