{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:58:09Z","timestamp":1791190689305,"version":"4.1.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Recent reports suggest that vascular factors play a crucial role in the development and progression of Alzheimer\u2019s disease. We aimed to assess vasomotor reactivity in patients with Alzheimer\u2019s disease and vascular dementia due to microangiopathy using transcranial Doppler sonography and near-infrared spectroscopy during a CO\n            <jats:sub>2<\/jats:sub>\n            exposition task.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            The normalized CO\n            <jats:sub>2<\/jats:sub>\n            reactivity assessed at the middle cerebral artery and the oxygenated and deoxygenated hemoglobin of the frontal cortex were obtained. To investigate the impact of cholinergic deficiency known for Alzheimer\u2019s disease on vasomotor reactivity, both groups were reinvestigated during treatment with the acetylcholine esterase inhibitor galantamine.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Transcranial Doppler analysis revealed significantly reduced normalized CO\n            <jats:sub>2<\/jats:sub>\n            reactivity for Alzheimer\u2019s disease and vascular dementia. Vasomotor reactivity assessed by near-infrared spectroscopy was decreased in patients with vascular dementia, but not in Alzheimer\u2019s disease. Galantamine treatment showed a beneficial effect, normalizing these parameters close to age-matched control levels.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Our results suggest that Alzheimer\u2019s disease is associated with a lack of vasomotor reactivity, which might be associated with disturbed autoregulation indicating a potential risk for a decreased protection of brain tissue against blood pressure changes. Additionally, a diminished increase of cortical oxygenated hemoglobin during the CO\n            <jats:sub>2<\/jats:sub>\n            test was apparent in patients with vascular dementia. Galantamine treatment influenced vascular reactivity in the CO\n            <jats:sub>2<\/jats:sub>\n            test, thus providing evidence for the cholinergic deficiency, thereby adding to vascular dysregulation in Alzheimer\u2019s disease, but also indicating an important role of cholinergic system dysfunction for vascular dementia.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.107.492033","type":"journal-article","created":{"date-parts":[[2007,10,25]],"date-time":"2007-10-25T23:46:10Z","timestamp":1193355970000},"page":"3186-3192","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":60,"title":["Influence of Galantamine on Vasomotor Reactivity in Alzheimer\u2019s Disease and Vascular Dementia Due to Cerebral Microangiopathy"],"prefix":"10.1161","volume":"38","author":[{"given":"Karl-Ju\u0308rgen","family":"Ba\u0308r","sequence":"first","affiliation":[{"name":"From the Department of Psychiatry (K.-J.B., N.S., H.S.), the Institute of Physiology I (M.K.B.), the Institute of Diagnostic and Interventional Radiology (H.J.M.), and the Department of Neurology (C.T.), Friedrich-Schiller-University Jena, Jena, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Karl","family":"Boettger","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry (K.-J.B., N.S., H.S.), the Institute of Physiology I (M.K.B.), the Institute of Diagnostic and Interventional Radiology (H.J.M.), and the Department of Neurology (C.T.), Friedrich-Schiller-University Jena, Jena, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Seidler","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry (K.-J.B., N.S., H.S.), the Institute of Physiology I (M.K.B.), the Institute of Diagnostic and Interventional Radiology (H.J.M.), and the Department of Neurology (C.T.), Friedrich-Schiller-University Jena, Jena, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Joachim","family":"Mentzel","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry (K.-J.B., N.S., H.S.), the Institute of Physiology I (M.K.B.), the Institute of Diagnostic and Interventional Radiology (H.J.M.), and the Department of Neurology (C.T.), Friedrich-Schiller-University Jena, Jena, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Terborg","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry (K.-J.B., N.S., H.S.), the Institute of Physiology I (M.K.B.), the Institute of Diagnostic and Interventional Radiology (H.J.M.), and the Department of Neurology (C.T.), Friedrich-Schiller-University Jena, Jena, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich","family":"Sauer","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry (K.-J.B., N.S., H.S.), the Institute of Physiology I (M.K.B.), the Institute of Diagnostic and Interventional Radiology (H.J.M.), and the Department of Neurology (C.T.), Friedrich-Schiller-University Jena, Jena, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"146","year":"1907","unstructured":"Alzheimer A \u00dcber eine eigenartige Erkrankung der Hirnrinde. 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