{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:05:10Z","timestamp":1790489110628,"version":"4.1.0"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Inflammation is a recognized risk factor for the vulnerable atherosclerotic plaque. The study explores the relationship between the degree of Magnetic Resonance (MR)\u2013defined inflammation using Ultra Small Super-Paramagnetic Iron Oxide (USPIO) particles and the severity of luminal stenosis in asymptomatic carotid plaques.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            Seventy-one patients with an asymptomatic carotid stenosis of \u226540% underwent multi-sequence USPIO-enhanced MR imaging. Stenosis severity was measured according to the NASCET and ECST methods.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            No demonstrable relationship between inflammation as measured by USPIO-enhanced signal change and the degree of luminal stenosis was found.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Inflammation and stenosis are likely to be independent risk factors, although this needs to be further validated.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.107.504753","type":"journal-article","created":{"date-parts":[[2008,5,4]],"date-time":"2008-05-04T04:48:25Z","timestamp":1209876505000},"page":"2144-2147","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":60,"title":["Correlation of Carotid Atheromatous Plaque Inflammation Using USPIO-Enhanced MR Imaging With Degree of Luminal Stenosis"],"prefix":"10.1161","volume":"39","author":[{"given":"Tjun Y.","family":"Tang","sequence":"first","affiliation":[{"name":"From the University Department of Radiology (T.Y.T., S.P.S.H., M.J.G., J.M.U., Z.Y.L., A.J.P., J.H.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Biostatistics and Data Sciences (S.R.M.), GlaxoSmithKline, Harlow, UK; Cambridge Vascular Unit (T.Y.T., S.R.W., K.V., M.E.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Academic Department of Neurosurgery (S.P.S.H., P.J.K.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; and the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon P.S.","family":"Howarth","sequence":"additional","affiliation":[{"name":"From the University Department of Radiology (T.Y.T., S.P.S.H., M.J.G., J.M.U., Z.Y.L., A.J.P., J.H.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Biostatistics and Data Sciences (S.R.M.), GlaxoSmithKline, Harlow, UK; Cambridge Vascular Unit (T.Y.T., S.R.W., K.V., M.E.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Academic Department of Neurosurgery (S.P.S.H., P.J.K.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; and the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam R.","family":"Miller","sequence":"additional","affiliation":[{"name":"From the University Department of Radiology (T.Y.T., S.P.S.H., M.J.G., J.M.U., Z.Y.L., A.J.P., J.H.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Biostatistics and Data Sciences (S.R.M.), GlaxoSmithKline, Harlow, UK; Cambridge Vascular Unit (T.Y.T., S.R.W., K.V., M.E.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Academic Department of Neurosurgery (S.P.S.H., P.J.K.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; and the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Graves","sequence":"additional","affiliation":[{"name":"From the University Department of Radiology (T.Y.T., S.P.S.H., M.J.G., J.M.U., Z.Y.L., A.J.P., J.H.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Biostatistics and Data Sciences (S.R.M.), GlaxoSmithKline, Harlow, UK; Cambridge Vascular Unit (T.Y.T., S.R.W., K.V., M.E.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Academic Department of Neurosurgery (S.P.S.H., P.J.K.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; and the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"U-King-Im","sequence":"additional","affiliation":[{"name":"From the University Department of Radiology (T.Y.T., S.P.S.H., M.J.G., J.M.U., Z.Y.L., A.J.P., J.H.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Biostatistics and Data Sciences (S.R.M.), GlaxoSmithKline, Harlow, UK; Cambridge Vascular Unit (T.Y.T., S.R.W., K.V., M.E.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Academic Department of Neurosurgery (S.P.S.H., P.J.K.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; and the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yong","family":"Li","sequence":"additional","affiliation":[{"name":"From the University Department of Radiology (T.Y.T., S.P.S.H., M.J.G., J.M.U., Z.Y.L., A.J.P., J.H.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Biostatistics and Data Sciences (S.R.M.), GlaxoSmithKline, Harlow, UK; Cambridge Vascular Unit (T.Y.T., S.R.W., K.V., M.E.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Academic Department of Neurosurgery (S.P.S.H., P.J.K.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; and the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart R.","family":"Walsh","sequence":"additional","affiliation":[{"name":"From the University Department of Radiology (T.Y.T., S.P.S.H., M.J.G., J.M.U., Z.Y.L., A.J.P., J.H.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Biostatistics and Data Sciences (S.R.M.), GlaxoSmithKline, Harlow, UK; Cambridge Vascular Unit (T.Y.T., S.R.W., K.V., M.E.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Academic Department of Neurosurgery (S.P.S.H., P.J.K.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; and the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Patterson","sequence":"additional","affiliation":[{"name":"From the University Department of Radiology (T.Y.T., S.P.S.H., M.J.G., J.M.U., Z.Y.L., A.J.P., J.H.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Biostatistics and Data Sciences (S.R.M.), GlaxoSmithKline, Harlow, UK; Cambridge Vascular Unit (T.Y.T., S.R.W., K.V., M.E.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Academic Department of Neurosurgery (S.P.S.H., P.J.K.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; and the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Kirkpatrick","sequence":"additional","affiliation":[{"name":"From the University Department of Radiology (T.Y.T., S.P.S.H., M.J.G., J.M.U., Z.Y.L., A.J.P., J.H.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Biostatistics and Data Sciences (S.R.M.), GlaxoSmithKline, Harlow, UK; Cambridge Vascular Unit (T.Y.T., S.R.W., K.V., M.E.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Academic Department of Neurosurgery (S.P.S.H., P.J.K.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; and the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Warburton","sequence":"additional","affiliation":[{"name":"From the University Department of Radiology (T.Y.T., S.P.S.H., M.J.G., J.M.U., Z.Y.L., A.J.P., J.H.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Biostatistics and Data Sciences (S.R.M.), GlaxoSmithKline, Harlow, UK; Cambridge Vascular Unit (T.Y.T., S.R.W., K.V., M.E.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Academic Department of Neurosurgery (S.P.S.H., P.J.K.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; and the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Varty","sequence":"additional","affiliation":[{"name":"From the University Department of Radiology (T.Y.T., S.P.S.H., M.J.G., J.M.U., Z.Y.L., A.J.P., J.H.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Biostatistics and Data Sciences (S.R.M.), GlaxoSmithKline, Harlow, UK; Cambridge Vascular Unit (T.Y.T., S.R.W., K.V., M.E.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Academic Department of Neurosurgery (S.P.S.H., P.J.K.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; and the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Gaunt","sequence":"additional","affiliation":[{"name":"From the University Department of Radiology (T.Y.T., S.P.S.H., M.J.G., J.M.U., Z.Y.L., A.J.P., J.H.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Biostatistics and Data Sciences (S.R.M.), GlaxoSmithKline, Harlow, UK; Cambridge Vascular Unit (T.Y.T., S.R.W., K.V., M.E.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Academic Department of Neurosurgery (S.P.S.H., P.J.K.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; and the..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Gillard","sequence":"additional","affiliation":[{"name":"From the University Department of Radiology (T.Y.T., S.P.S.H., M.J.G., J.M.U., Z.Y.L., A.J.P., J.H.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Biostatistics and Data Sciences (S.R.M.), GlaxoSmithKline, Harlow, UK; Cambridge Vascular Unit (T.Y.T., S.R.W., K.V., M.E.G.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Academic Department of Neurosurgery (S.P.S.H., P.J.K.), Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; and the..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000190895.51934.43"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000222920.59760.df"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000236063.47539.99"},{"key":"e_1_3_2_4_2","unstructured":"Tang T Howarth S Miller S Graves M U-King-Im JM Trivedi R Li Z Walsh S Brown A Kirkpatrick P Gaunt M Gillard J. Comparison of the inflammatory burden of truly asymptomatic carotid atheroma with atherosclerotic plaques contralateral to symptomatic carotid stenosis: An ultrasmall superparamagnetic iron oxide enhanced magnetic resonance study. J Neurol Neurosurg Psychiatry. In press."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.102.9.959"},{"key":"e_1_3_2_6_2","first-page":"1154","volume":"14","year":"2004","unstructured":"U-King-Im JM, Trivedi RA, Sala E, Graves MJ, Gaskarth M, Higgins NJ, Cross JC, Hollingworth W, Coulden RA, Kirkpatrick PJ, Antoun NM, Gillard JH. Evaluation of carotid stenosis with axial high-resolution black-blood mr imaging. Eur Radiol. 2004; 14: 1154\u20131161.","journal-title":"Eur Radiol"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.107.504753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:39:22Z","timestamp":1715603962000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.107.504753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":6,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1161\/STROKEAHA.107.504753"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.107.504753","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7]]},"assertion":[{"value":"2007-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-11-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}