{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:03:33Z","timestamp":1791291813071,"version":"4.1.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            The prognosis of acute basilar artery occlusion (BAO) is poor if early recanalization is not achieved. Recanalization strategies include intravenous thrombolysis (IVT) and intra-arterial thrombolysis, as well as endovascular mechanical thrombectomy (EMT). The combination of IVT with consecutive on-demand EMT may allow for early treatment initiation with high recanalization rates but has never been systematically tested in patients with BAO.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            Starting in January 2006, we treated all eligible patients with acute BAO admitted to our academic stroke center or one of our cooperating community hospitals after a standardized protocol combining IVT with consecutive on-demand EMT. Inclusion criteria were: (1) presence of predefined symptoms clearly suggestive of BAO; (2) exclusion of intracerebral hemorrhage on CT scan; (3) evidence of BAO on CT angiography; (4) start of therapy within 6 hours after symptom onset; and (5) no contraindications for IVT. If CT angiography showed persistent BAO after IVT, EMT was performed.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Since January 2006, 16 patients have been treated. All patients received IVT; in 7 of them, EMT became necessary because of persistent BAO. Final recanalization was achieved in 15 patients. Three months after therapy, 12 of 16 patients were still alive; 7 of them had a good outcome (modified Rankin score \u22642).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Our data suggest that the combination of IVT with on-demand consecutive EMT in BAO is feasible, allows for early treatment, and provides excellent recanalization rates.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.107.505123","type":"journal-article","created":{"date-parts":[[2008,3,7]],"date-time":"2008-03-07T02:25:35Z","timestamp":1204856735000},"page":"1496-1500","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":65,"title":["Staged Escalation Therapy in Acute Basilar Artery Occlusion"],"prefix":"10.1161","volume":"39","author":[{"given":"Thomas","family":"Pfefferkorn","sequence":"first","affiliation":[{"name":"From Department of Neurology (T.P., C.O., N.P., A.S., H.W.P., M.D.) and Department of Neuroradiology (T.E.M., M.H., S.M.-S., M.W.), Klinikum Grosshadern, University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Mayer","sequence":"additional","affiliation":[{"name":"From Department of Neurology (T.P., C.O., N.P., A.S., H.W.P., M.D.) and Department of Neuroradiology (T.E.M., M.H., S.M.-S., M.W.), Klinikum Grosshadern, University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Opherk","sequence":"additional","affiliation":[{"name":"From Department of Neurology (T.P., C.O., N.P., A.S., H.W.P., M.D.) and Department of Neuroradiology (T.E.M., M.H., S.M.-S., M.W.), Klinikum Grosshadern, University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Peters","sequence":"additional","affiliation":[{"name":"From Department of Neurology (T.P., C.O., N.P., A.S., H.W.P., M.D.) and Department of Neuroradiology (T.E.M., M.H., S.M.-S., M.W.), Klinikum Grosshadern, University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Straube","sequence":"additional","affiliation":[{"name":"From Department of Neurology (T.P., C.O., N.P., A.S., H.W.P., M.D.) and Department of Neuroradiology (T.E.M., M.H., S.M.-S., M.W.), Klinikum Grosshadern, University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Walter","family":"Pfister","sequence":"additional","affiliation":[{"name":"From Department of Neurology (T.P., C.O., N.P., A.S., H.W.P., M.D.) and Department of Neuroradiology (T.E.M., M.H., S.M.-S., M.W.), Klinikum Grosshadern, University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Holtmannspo\u0308tter","sequence":"additional","affiliation":[{"name":"From Department of Neurology (T.P., C.O., N.P., A.S., H.W.P., M.D.) and Department of Neuroradiology (T.E.M., M.H., S.M.-S., M.W.), Klinikum Grosshadern, University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Mu\u0308ller-Schunk","sequence":"additional","affiliation":[{"name":"From Department of Neurology (T.P., C.O., N.P., A.S., H.W.P., M.D.) and Department of Neuroradiology (T.E.M., M.H., S.M.-S., M.W.), Klinikum Grosshadern, University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Wiesmann","sequence":"additional","affiliation":[{"name":"From Department of Neurology (T.P., C.O., N.P., A.S., H.W.P., M.D.) and Department of Neuroradiology (T.E.M., M.H., S.M.-S., M.W.), Klinikum Grosshadern, University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Dichgans","sequence":"additional","affiliation":[{"name":"From Department of Neurology (T.P., C.O., N.P., A.S., H.W.P., M.D.) and Department of Neuroradiology (T.E.M., M.H., S.M.-S., M.W.), Klinikum Grosshadern, University of Munich, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.19.10.3176080"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.27.5.875"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.8.3.860293"},{"key":"e_1_3_2_4_2","first-page":"2042","volume":"27","year":"2006","unstructured":"Schulte-Altedorneburg G, Hamann GF, Mull M, Kuhne D, Liebetrau M, Weber W, Bruckmann H, Mayer TE. 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AJNR Am J Neuroradiol. 2006; 27: 1177\u20131182.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.76.1.142"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000055766.99908.58"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60149-4"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000204120.79399.72"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.107.505123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:26:30Z","timestamp":1715603190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.107.505123"}},"subtitle":["Intravenous Thrombolysis and On-Demand Consecutive Endovascular Mechanical Thrombectomy: Preliminary Experience in 16 Patients"],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1161\/STROKEAHA.107.505123"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.107.505123","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"2007-09-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-10-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-03-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}