{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:37:50Z","timestamp":1772109470930,"version":"3.50.1"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            The possible cause of chronic hydrocephalus after subarachnoid hemorrhage (SAH) has been reported to be meningeal fibrosis. We examined whether the induction of tenascin-C (TN-C), an extracellular matrix glycoprotein known to promote tissue fibrosis, was associated with chronic hydrocephalus after SAH.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            We prospectively measured cerebrospinal fluid TN-C levels in 7 control patients with unruptured cerebral aneurysms and in 29 consecutive patients with aneurysmal SAH on days 1 to 12.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Cerebrospinal fluid TN-C levels were less than the diagnostic threshold level in control patients but markedly increased after SAH. Higher TN-C levels were observed in patients with more severe SAH on admission CT, ventricular drainage for acute obstructive hydrocephalus, and a worse outcome. Independent of these factors, however, cerebrospinal fluid TN-C levels were significantly higher in patients with than without subsequent chronic shunt-dependent hydrocephalus on days 1 to 9.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            These findings suggest the possible involvement of TN-C in the development of chronic hydrocephalus after SAH and encourage further studies.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.107.505735","type":"journal-article","created":{"date-parts":[[2008,3,7]],"date-time":"2008-03-07T02:25:35Z","timestamp":1204856735000},"page":"1610-1612","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Cerebrospinal Fluid Tenascin-C Increases Preceding the Development of Chronic Shunt-Dependent Hydrocephalus After Subarachnoid Hemorrhage"],"prefix":"10.1161","volume":"39","author":[{"given":"Hidenori","family":"Suzuki","sequence":"first","affiliation":[{"name":"From Department of Neurosurgery (H.S., W.T.), Mie University Graduate School of Medicine, Tsu, Japan; Immuno-Biological Laboratories (N.K.), Takasaki, Japan; Department of Pathology and Matrix Biology (K.I.-Y., T.Y.), Mie University Graduate School of Medicine, Tsu, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"From Department of Neurosurgery (H.S., W.T.), Mie University Graduate School of Medicine, Tsu, Japan; Immuno-Biological Laboratories (N.K.), Takasaki, Japan; Department of Pathology and Matrix Biology (K.I.-Y., T.Y.), Mie University Graduate School of Medicine, Tsu, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Imanaka-Yoshida","sequence":"additional","affiliation":[{"name":"From Department of Neurosurgery (H.S., W.T.), Mie University Graduate School of Medicine, Tsu, Japan; Immuno-Biological Laboratories (N.K.), Takasaki, Japan; Department of Pathology and Matrix Biology (K.I.-Y., T.Y.), Mie University Graduate School of Medicine, Tsu, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshimichi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"From Department of Neurosurgery (H.S., W.T.), Mie University Graduate School of Medicine, Tsu, Japan; Immuno-Biological Laboratories (N.K.), Takasaki, Japan; Department of Pathology and Matrix Biology (K.I.-Y., T.Y.), Mie University Graduate School of Medicine, Tsu, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waro","family":"Taki","sequence":"additional","affiliation":[{"name":"From Department of Neurosurgery (H.S., W.T.), Mie University Graduate School of Medicine, Tsu, Japan; Immuno-Biological Laboratories (N.K.), Takasaki, Japan; Department of Pathology and Matrix Biology (K.I.-Y., T.Y.), Mie University Graduate School of Medicine, Tsu, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.86.3.0462"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1999.91.1.0080"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-211-75718-5_35"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1415"},{"key":"e_1_3_2_5_2","unstructured":"Suzuki H Kanamaru K Suzuki Y Aimi Y Matsubara N Araki T Takayasu M Kinoshita N Imanaka-Yoshida K Yoshida T Taki W. Possible role of tenascin-C in cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Acta Neurochir Suppl. In press."}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.107.505735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:28:25Z","timestamp":1715603305000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.107.505735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1161\/STROKEAHA.107.505735"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.107.505735","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"2007-09-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-10-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-03-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}