{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:06:09Z","timestamp":1778839569954,"version":"3.51.4"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Diabetes type 2 (DM2) is associated with accelerated cognitive decline and structural brain abnormalities. Macrovascular disease has been described as a determinant for brain MRI changes in DM2, but little is known about the involvement of other DM2-related factors.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            Brain MRI was performed in 1043 participants (151 DM2) with symptomatic arterial disease. Brain volumes were obtained through automated segmentation.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Patients with arterial disease and DM2 had more global and subcortical brain atrophy (\u22121.20% brain\/intracranial volume [95%CI \u22121.58 to \u22120.82],\n            <jats:italic>P<\/jats:italic>\n            &lt;0.0005 and 0.20% ventricular\/intracranial volume [0.05 to 0.34],\n            <jats:italic>P<\/jats:italic>\n            &lt;0.01), larger WMH volumes (0.22 logtransformed volume [0.07 to 0.38],\n            <jats:italic>P<\/jats:italic>\n            &lt;0.005), and more lacunar infarcts (OR 1.75 [1.13 to 2.69],\n            <jats:italic>P<\/jats:italic>\n            &lt;0.01) than identical patients without DM2. In patients with DM2, high glucose levels (B\u22120.12% per mmol\/L [\u22120.23 to \u22120.01],\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05) and diabetes duration (B\u22120.05% per year [\u22120.10 to \u22120.001],\n            <jats:italic>P<\/jats:italic>\n            &lt;0.05) were associated with global brain atrophy.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion\u2014<\/jats:italic>\n            <\/jats:bold>\n            In patients with symptomatic arterial disease, DM2 has an added detrimental effect on the brain. In patients with DM2, hyperglycemia and diabetes duration contribute to brain atrophy.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.107.506089","type":"journal-article","created":{"date-parts":[[2008,3,28]],"date-time":"2008-03-28T01:35:47Z","timestamp":1206668147000},"page":"1600-1603","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":86,"title":["Diabetes Increases Atrophy and Vascular Lesions on Brain MRI in Patients With Symptomatic Arterial Disease"],"prefix":"10.1161","volume":"39","author":[{"given":"Audrey M.","family":"Tiehuis","sequence":"first","affiliation":[{"name":"From the Department of Radiology and Image Sciences Institute (A.M.T., K.L.V., A.P.A.A., W.P.T.M.M.); Julius Center for Health Sciences and Primary Care (Y.v.d.G., A.P.A.A.); the Department of Internal Medicine (F.L.V.); and Rudolf Magnus Institute of Neuroscience, Department of Neurology, University Medical Center Utrecht, the Netherlands (G.J.B., L.J.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"van der Graaf","sequence":"additional","affiliation":[{"name":"From the Department of Radiology and Image Sciences Institute (A.M.T., K.L.V., A.P.A.A., W.P.T.M.M.); Julius Center for Health Sciences and Primary Care (Y.v.d.G., A.P.A.A.); the Department of Internal Medicine (F.L.V.); and Rudolf Magnus Institute of Neuroscience, Department of Neurology, University Medical Center Utrecht, the Netherlands (G.J.B., L.J.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank L.","family":"Visseren","sequence":"additional","affiliation":[{"name":"From the Department of Radiology and Image Sciences Institute (A.M.T., K.L.V., A.P.A.A., W.P.T.M.M.); Julius Center for Health Sciences and Primary Care (Y.v.d.G., A.P.A.A.); the Department of Internal Medicine (F.L.V.); and Rudolf Magnus Institute of Neuroscience, Department of Neurology, University Medical Center Utrecht, the Netherlands (G.J.B., L.J.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen L.","family":"Vincken","sequence":"additional","affiliation":[{"name":"From the Department of Radiology and Image Sciences Institute (A.M.T., K.L.V., A.P.A.A., W.P.T.M.M.); Julius Center for Health Sciences and Primary Care (Y.v.d.G., A.P.A.A.); the Department of Internal Medicine (F.L.V.); and Rudolf Magnus Institute of Neuroscience, Department of Neurology, University Medical Center Utrecht, the Netherlands (G.J.B., L.J.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert Jan","family":"Biessels","sequence":"additional","affiliation":[{"name":"From the Department of Radiology and Image Sciences Institute (A.M.T., K.L.V., A.P.A.A., W.P.T.M.M.); Julius Center for Health Sciences and Primary Care (Y.v.d.G., A.P.A.A.); the Department of Internal Medicine (F.L.V.); and Rudolf Magnus Institute of Neuroscience, Department of Neurology, University Medical Center Utrecht, the Netherlands (G.J.B., L.J.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Auke P.A.","family":"Appelman","sequence":"additional","affiliation":[{"name":"From the Department of Radiology and Image Sciences Institute (A.M.T., K.L.V., A.P.A.A., W.P.T.M.M.); Julius Center for Health Sciences and Primary Care (Y.v.d.G., A.P.A.A.); the Department of Internal Medicine (F.L.V.); and Rudolf Magnus Institute of Neuroscience, Department of Neurology, University Medical Center Utrecht, the Netherlands (G.J.B., L.J.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Jaap","family":"Kappelle","sequence":"additional","affiliation":[{"name":"From the Department of Radiology and Image Sciences Institute (A.M.T., K.L.V., A.P.A.A., W.P.T.M.M.); Julius Center for Health Sciences and Primary Care (Y.v.d.G., A.P.A.A.); the Department of Internal Medicine (F.L.V.); and Rudolf Magnus Institute of Neuroscience, Department of Neurology, University Medical Center Utrecht, the Netherlands (G.J.B., L.J.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem P.T.M.","family":"Mali","sequence":"additional","affiliation":[{"name":"From the Department of Radiology and Image Sciences Institute (A.M.T., K.L.V., A.P.A.A., W.P.T.M.M.); Julius Center for Health Sciences and Primary Care (Y.v.d.G., A.P.A.A.); the Department of Internal Medicine (F.L.V.); and Rudolf Magnus Institute of Neuroscience, Department of Neurology, University Medical Center Utrecht, the Netherlands (G.J.B., L.J.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.1999.00027.x"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1637"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.25.2.8303738"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000052631.98405.15"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91144-B"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.55.04.06.db05-1323"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007621514757"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.05.046"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.107.506089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:28:16Z","timestamp":1715603296000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.107.506089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1161\/STROKEAHA.107.506089"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.107.506089","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"2007-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-10-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-03-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}