{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:54:03Z","timestamp":1761540843832},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            An animal model of selective middle cerebral artery (MCA) occlusion is needed for evaluation of intra-arterial (IA) delivery of thrombolytic agents. We describe a technique for MCA thrombo-occlusion in the rabbit with real-time angiographic documentation of occlusion and thrombolytic recanalization.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            After femoral artery cutdown, a microcatheter was advanced from the internal carotid artery to the MCA. MCA occlusion was achieved by IA thrombin and reperfusion by IA plasmin.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            The terminal internal carotid artery was successfully catheterized in 12 of 13 animals. Stable (2-hour) MCA occlusion was induced and verified angiographically in all 12 animals; 2 animals also had distal internal carotid artery thrombus. Recanalization was achieved rapidly after IA plasmin in 3 of 3 animals.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            We describe a new animal model of selective MCA occlusion documented by real-time angiography and used to demonstrate recanalization with IA plasmin.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.107.507376","type":"journal-article","created":{"date-parts":[[2008,3,15]],"date-time":"2008-03-15T00:13:09Z","timestamp":1205539989000},"page":"1613-1615","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Middle Cerebral Artery Occlusion in the Rabbit Using Selective Angiography"],"prefix":"10.1161","volume":"39","author":[{"given":"Reza","family":"Jahan","sequence":"first","affiliation":[{"name":"From the Departments of Radiological Sciences (R.J., F.V.), Medicine (D.S., V.J.M.), Pathology &amp; Laboratory Medicine (H.V.V., W.Y.), Neurology (H.V.V., V.J.M.), David Geffen School of Medicine at UCLA, Los Angeles, Calif; and R&amp;D BioAnalytics (P.V.), Talecris Biotherapeutics, Research Triangle Park, NC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphne","family":"Stewart","sequence":"additional","affiliation":[{"name":"From the Departments of Radiological Sciences (R.J., F.V.), Medicine (D.S., V.J.M.), Pathology &amp; Laboratory Medicine (H.V.V., W.Y.), Neurology (H.V.V., V.J.M.), David Geffen School of Medicine at UCLA, Los Angeles, Calif; and R&amp;D BioAnalytics (P.V.), Talecris Biotherapeutics, Research Triangle Park, NC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry V.","family":"Vinters","sequence":"additional","affiliation":[{"name":"From the Departments of Radiological Sciences (R.J., F.V.), Medicine (D.S., V.J.M.), Pathology &amp; Laboratory Medicine (H.V.V., W.Y.), Neurology (H.V.V., V.J.M.), David Geffen School of Medicine at UCLA, Los Angeles, Calif; and R&amp;D BioAnalytics (P.V.), Talecris Biotherapeutics, Research Triangle Park, NC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Yong","sequence":"additional","affiliation":[{"name":"From the Departments of Radiological Sciences (R.J., F.V.), Medicine (D.S., V.J.M.), Pathology &amp; Laboratory Medicine (H.V.V., W.Y.), Neurology (H.V.V., V.J.M.), David Geffen School of Medicine at UCLA, Los Angeles, Calif; and R&amp;D BioAnalytics (P.V.), Talecris Biotherapeutics, Research Triangle Park, NC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Vinuela","sequence":"additional","affiliation":[{"name":"From the Departments of Radiological Sciences (R.J., F.V.), Medicine (D.S., V.J.M.), Pathology &amp; Laboratory Medicine (H.V.V., W.Y.), Neurology (H.V.V., V.J.M.), David Geffen School of Medicine at UCLA, Los Angeles, Calif; and R&amp;D BioAnalytics (P.V.), Talecris Biotherapeutics, Research Triangle Park, NC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pete","family":"Vandeberg","sequence":"additional","affiliation":[{"name":"From the Departments of Radiological Sciences (R.J., F.V.), Medicine (D.S., V.J.M.), Pathology &amp; Laboratory Medicine (H.V.V., W.Y.), Neurology (H.V.V., V.J.M.), David Geffen School of Medicine at UCLA, Los Angeles, Calif; and R&amp;D BioAnalytics (P.V.), Talecris Biotherapeutics, Research Triangle Park, NC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor J.","family":"Marder","sequence":"additional","affiliation":[{"name":"From the Departments of Radiological Sciences (R.J., F.V.), Medicine (D.S., V.J.M.), Pathology &amp; Laboratory Medicine (H.V.V., W.Y.), Neurology (H.V.V., V.J.M.), David Geffen School of Medicine at UCLA, Los Angeles, Calif; and R&amp;D BioAnalytics (P.V.), Talecris Biotherapeutics, Research Triangle Park, NC."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00128.x"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000027436.82700.73"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.33.1.147"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.21.11.2122552"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(97)00184-6"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3995\/jstroke.8.1"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.29.10.2162"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20100"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(02)00322-9"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1616127"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2546"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.107.507376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:28:27Z","timestamp":1715603307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.107.507376"}},"subtitle":["Application for Assessment of Thrombolysis"],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1161\/STROKEAHA.107.507376"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.107.507376","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"2007-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-10-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}