{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:29:24Z","timestamp":1790461764311,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            The aim of this exploratory analysis was to evaluate if a combination of MR angiography (MRA) and diffusion-weighted imaging (DWI) selection criteria can be used to identify patients with acute stroke who are likely to benefit from early reperfusion.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            Data from DEFUSE, a study of 74 patients with stroke who received intravenous tissue plasminogen activator in the 3- to 6-hour time window and underwent MRIs before and approximately 4 hours after treatment were analyzed. The MRA-DWI mismatch model was defined as (1) a DWI lesion volume less than 25 mL in patients with a proximal vessel occlusion; or (2) a DWI lesion volume less than 15 mL in patients with proximal vessel stenosis or an abnormal finding of a distal vessel. Favorable clinical response was defined as an improvement on the National Institutes of Health Stroke Scale score of at least 8 points between baseline and 30 days or a National Institutes of Health Stroke Scale score \u22641 at 30 days.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Twenty-seven of 62 patients (44%) had an MRA-DWI mismatch. There was a differential response to early reperfusion based on MRA-DWI mismatch status. Reperfusion was associated with an increased rate of a favorable clinical response in patients with an MRA-DWI mismatch (OR, 12.5; 95% CI, 1.8 to 83.9) and a lower rate in patients without mismatch (OR, 0.2; 95% CI, 0.0 to 0.8).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            The MRA-DWI mismatch model appears to identify patients with stroke who are likely to benefit from reperfusion therapy administered in the 3- to 6-hour time window after symptom onset. The criteria established for the MRA-DWI mismatch model in this study require validation in an independent cohort.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.107.508572","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T02:05:24Z","timestamp":1216346724000},"page":"2491-2496","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":97,"title":["The MRA-DWI Mismatch Identifies Patients With Stroke Who Are Likely to Benefit From Reperfusion"],"prefix":"10.1161","volume":"39","author":[{"given":"Maarten G.","family":"Lansberg","sequence":"first","affiliation":[{"name":"From the Stanford Stroke Center (M.G.L., R.B., J.M.O., M.M., S.K., G.W.A.), Stanford University Medical Center, Palo Alto, Calif; the Department of Neurology (V.N.T.), University Hospitals of Leuven, Leuven, Belgium; and the Stroke Institute (L.R.W.), University of Pittsburgh Medical Center, Pittsburgh, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent N.","family":"Thijs","sequence":"additional","affiliation":[{"name":"From the Stanford Stroke Center (M.G.L., R.B., J.M.O., M.M., S.K., G.W.A.), Stanford University Medical Center, Palo Alto, Calif; the Department of Neurology (V.N.T.), University Hospitals of Leuven, Leuven, Belgium; and the Stroke Institute (L.R.W.), University of Pittsburgh Medical Center, Pittsburgh, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Bammer","sequence":"additional","affiliation":[{"name":"From the Stanford Stroke Center (M.G.L., R.B., J.M.O., M.M., S.K., G.W.A.), Stanford University Medical Center, Palo Alto, Calif; the Department of Neurology (V.N.T.), University Hospitals of Leuven, Leuven, Belgium; and the Stroke Institute (L.R.W.), University of Pittsburgh Medical Center, Pittsburgh, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Olivot","sequence":"additional","affiliation":[{"name":"From the Stanford Stroke Center (M.G.L., R.B., J.M.O., M.M., S.K., G.W.A.), Stanford University Medical Center, Palo Alto, Calif; the Department of Neurology (V.N.T.), University Hospitals of Leuven, Leuven, Belgium; and the Stroke Institute (L.R.W.), University of Pittsburgh Medical Center, Pittsburgh, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Marks","sequence":"additional","affiliation":[{"name":"From the Stanford Stroke Center (M.G.L., R.B., J.M.O., M.M., S.K., G.W.A.), Stanford University Medical Center, Palo Alto, Calif; the Department of Neurology (V.N.T.), University Hospitals of Leuven, Leuven, Belgium; and the Stroke Institute (L.R.W.), University of Pittsburgh Medical Center, Pittsburgh, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence R.","family":"Wechsler","sequence":"additional","affiliation":[{"name":"From the Stanford Stroke Center (M.G.L., R.B., J.M.O., M.M., S.K., G.W.A.), Stanford University Medical Center, Palo Alto, Calif; the Department of Neurology (V.N.T.), University Hospitals of Leuven, Leuven, Belgium; and the Stroke Institute (L.R.W.), University of Pittsburgh Medical Center, Pittsburgh, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Kemp","sequence":"additional","affiliation":[{"name":"From the Stanford Stroke Center (M.G.L., R.B., J.M.O., M.M., S.K., G.W.A.), Stanford University Medical Center, Palo Alto, Calif; the Department of Neurology (V.N.T.), University Hospitals of Leuven, Leuven, Belgium; and the Stroke Institute (L.R.W.), University of Pittsburgh Medical Center, Pittsburgh, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W.","family":"Albers","sequence":"additional","affiliation":[{"name":"From the Stanford Stroke Center (M.G.L., R.B., J.M.O., M.M., S.K., G.W.A.), Stanford University Medical Center, Palo Alto, Calif; the Department of Neurology (V.N.T.), University Hospitals of Leuven, Leuven, Belgium; and the Stroke Institute (L.R.W.), University of Pittsburgh Medical Center, Pittsburgh, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15692-4"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.21.2003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20976"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200502000-00010"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-005-0012-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360511"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910360510"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.483842"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000130570.41127.EA"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.106.480145"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.106.479154"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.31.11.2597"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.2.418"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000047705"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100004704"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000217403.66996.6d"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000149938.08731.2c"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2451070353"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006060601"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.58.7.1069"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000051504.10095.9c"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000032244.03134.37"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000131271.54098.22"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000256366.86353.ff"},{"key":"e_1_3_2_25_2","first-page":"20","volume":"27","year":"2006","unstructured":"Schaefer PW, Roccatagliata L, Ledezma C, Hoh B, Schwamm LH, Koroshetz W, Gonzalez RG, Lev MH. 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