{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T10:12:51Z","timestamp":1773915171467,"version":"3.50.1"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            A hypoxic-ischemic origin of transient global amnesia (TGA) has been suggested on the basis of the observation of infarctlike diffusion-weighted imaging (DWI) abnormalities in some affected individuals. We tested this hypothesis by comparing vascular risk factors, magnetic resonance imaging (MRI) markers of cerebral small-vessel disease, and other evidence of a cerebrovascular disorder between TGA patients with (DWI+) and without (DWI\u2212) DWI lesions and normal community-based controls.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            We retrospectively identified 86 patients hospitalized for TGA (mean\u00b1SD age, 65.9\u00b110.9 years; 62% female). Brain MRI at 1.5 T was assessed for DWI lesions exhibiting restricted diffusion (ie, DWI+), white-matter hyperintensities, lacunes, and chronic infarcts (median time lag to clinical onset, 66.6\u00b154.6 hours). Vascular risk factors and findings from duplex sonography, ECG, and echocardiography were recorded. A 1:2 age- and sex-matched sample of 172 elderly subjects (mean\u00b1SD age, 65.6\u00b19.3 years; 62% female) free of neuropsychiatric disease served for comparison.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            DWI lesions were observed in 10 patients with TGA (11.5%; mean\u00b1SD age, 68.3\u00b15.4 years; 8 women). They were all small and located in the mesiotemporal region (9 left hemisphere, 5 right hemisphere). The vascular risk profile of TGA patients and concomitant changes on brain MRI were comparable with those of healthy controls and did not show significant differences between DWI+ and DWI\u2212 subjects. A comprehensive diagnostic workup also provided no evidence for a higher rate of cerebrovascular disorder-related abnormalities in either the total group of TGA patients or TGA DWI+ patients.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            These findings do not support a cerebrovascular etiology of TGA, even in those individuals showing acute DWI lesions. Other pathophysiologic mechanisms need to be explored.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.107.508655","type":"journal-article","created":{"date-parts":[[2008,6,27]],"date-time":"2008-06-27T01:37:26Z","timestamp":1214530646000},"page":"2219-2225","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":81,"title":["Transient Global Amnesia"],"prefix":"10.1161","volume":"39","author":[{"given":"Christian","family":"Enzinger","sequence":"first","affiliation":[{"name":"From the Department of Neurology (C.E., S.R., R.S., F.F.) and the Section of Neuroradiology (C.E., F.T., F.E.), Department of Radiology, Medical University of Graz, Graz; and the Department of Neurology (P.K.), Villach, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Thimary","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (C.E., S.R., R.S., F.F.) and the Section of Neuroradiology (C.E., F.T., F.E.), Department of Radiology, Medical University of Graz, Graz; and the Department of Neurology (P.K.), Villach, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kapeller","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (C.E., S.R., R.S., F.F.) and the Section of Neuroradiology (C.E., F.T., F.E.), Department of Radiology, Medical University of Graz, Graz; and the Department of Neurology (P.K.), Villach, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Ropele","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (C.E., S.R., R.S., F.F.) and the Section of Neuroradiology (C.E., F.T., F.E.), Department of Radiology, Medical University of Graz, Graz; and the Department of Neurology (P.K.), Villach, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhold","family":"Schmidt","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (C.E., S.R., R.S., F.F.) and the Section of Neuroradiology (C.E., F.T., F.E.), Department of Radiology, Medical University of Graz, Graz; and the Department of Neurology (P.K.), Villach, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Ebner","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (C.E., S.R., R.S., F.F.) and the Section of Neuroradiology (C.E., F.T., F.E.), Department of Radiology, Medical University of Graz, Graz; and the Department of Neurology (P.K.), Villach, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Fazekas","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (C.E., S.R., R.S., F.F.) and the Section of Neuroradiology (C.E., F.T., F.E.), Department of Radiology, Medical University of Graz, Graz; and the Department of Neurology (P.K.), Villach, Austria."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/113.3.639"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/01688639008401030"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70121-6"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2000.102005275.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl105"},{"key":"e_1_3_3_6_2","first-page":"143","volume":"83","year":"1958","unstructured":"Fisher CM, Adams R. 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