{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:01:07Z","timestamp":1791054067681,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            We evaluate white matter (WM) injury after hypoxic-ischemic (HI) insult in a neonatal rat model using diffusion tensor imaging (DTI) to determine whether \u03bb\n            <jats:sub>\u2225<\/jats:sub>\n            and \u03bb\n            <jats:sub>\u22a5<\/jats:sub>\n            are able to characterize type and severity of brain damage.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            Eighteen 7-day-old Sprague-Dawley rats underwent unilateral ligation of left common carotid artery followed by 50 minutes (n=9) or 90 minutes (n=9) of hypoxia at 37\u00b0C. Rats were divided into 2 groups, according to absence (group A, n=11) or presence (group B, n=7) of cystic lesions on D7 post-HI T2-weighted imaging. DTI was performed for all rats at D1 and for group A rats at D7 post-HI. Signal intensity of ipsilateral and contralateral external capsule (EC) on D1 was compared by paired\n            <jats:italic>t<\/jats:italic>\n            test, with histological correlation.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Group A rats had significantly reduced FA, elevated trace, elevated \u03bb\n            <jats:sub>\u22a5,<\/jats:sub>\n            and similar \u03bb\n            <jats:sub>\u2225<\/jats:sub>\n            on D1 in the ipsilateral compared to contralateral EC, whereas group B rats had significant reduction in all parameters in the ipsilateral EC. Elevated trace normalized on D7 in group A rats. Histopathologic results demonstrated reduced myelination in group A noncystic HI and severe necrosis in group B cystic HI.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Increased \u03bb\n            <jats:sub>\u22a5<\/jats:sub>\n            with no significant change in \u03bb\n            <jats:sub>\u2225<\/jats:sub>\n            appears to characterize noncystic WM injury with reduced myelination, whereas reduction in both \u03bb\n            <jats:sub>\u2225<\/jats:sub>\n            and \u03bb\n            <jats:sub>\u22a5<\/jats:sub>\n            characterize severe damage with loss of structural integrity and necrosis. Combining with FA and trace, \u03bb\n            <jats:sub>\u2225<\/jats:sub>\n            and \u03bb\n            <jats:sub>\u22a5<\/jats:sub>\n            provide additional information which reflects type and severity of HI injury.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.107.509927","type":"journal-article","created":{"date-parts":[[2008,6,6]],"date-time":"2008-06-06T01:36:35Z","timestamp":1212716195000},"page":"2348-2353","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":77,"title":["Characterization of White Matter Injury in a Hypoxic-Ischemic Neonatal Rat Model by Diffusion Tensor MRI"],"prefix":"10.1161","volume":"39","author":[{"given":"Silun","family":"Wang","sequence":"first","affiliation":[{"name":"From the Department of Diagnostic Radiology (S.W., C.N.T., P.-L.K.), The University of Hong Kong; the Laboratory of Biomedical Imaging and Signal Processing, Department of Electrical and Electronic Engineering (E.X.W., H.-F.L.), The University of Hong Kong; and the Department of Pediatric and Adolescent Medicine (P.-T.C.), The University of Hong Kong, Hong Kong."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed X.","family":"Wu","sequence":"additional","affiliation":[{"name":"From the Department of Diagnostic Radiology (S.W., C.N.T., P.-L.K.), The University of Hong Kong; the Laboratory of Biomedical Imaging and Signal Processing, Department of Electrical and Electronic Engineering (E.X.W., H.-F.L.), The University of Hong Kong; and the Department of Pediatric and Adolescent Medicine (P.-T.C.), The University of Hong Kong, Hong Kong."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung Nga","family":"Tam","sequence":"additional","affiliation":[{"name":"From the Department of Diagnostic Radiology (S.W., C.N.T., P.-L.K.), The University of Hong Kong; the Laboratory of Biomedical Imaging and Signal Processing, Department of Electrical and Electronic Engineering (E.X.W., H.-F.L.), The University of Hong Kong; and the Department of Pediatric and Adolescent Medicine (P.-T.C.), The University of Hong Kong, Hong Kong."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Fai","family":"Lau","sequence":"additional","affiliation":[{"name":"From the Department of Diagnostic Radiology (S.W., C.N.T., P.-L.K.), The University of Hong Kong; the Laboratory of Biomedical Imaging and Signal Processing, Department of Electrical and Electronic Engineering (E.X.W., H.-F.L.), The University of Hong Kong; and the Department of Pediatric and Adolescent Medicine (P.-T.C.), The University of Hong Kong, Hong Kong."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pik-To","family":"Cheung","sequence":"additional","affiliation":[{"name":"From the Department of Diagnostic Radiology (S.W., C.N.T., P.-L.K.), The University of Hong Kong; the Laboratory of Biomedical Imaging and Signal Processing, Department of Electrical and Electronic Engineering (E.X.W., H.-F.L.), The University of Hong Kong; and the Department of Pediatric and Adolescent Medicine (P.-T.C.), The University of Hong Kong, Hong Kong."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pek-Lan","family":"Khong","sequence":"additional","affiliation":[{"name":"From the Department of Diagnostic Radiology (S.W., C.N.T., P.-L.K.), The University of Hong Kong; the Laboratory of Biomedical Imaging and Signal Processing, Department of Electrical and Electronic Engineering (E.X.W., H.-F.L.), The University of Hong Kong; and the Department of Pediatric and Adolescent Medicine (P.-T.C.), The University of Hong Kong, Hong Kong."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0545"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.07.065"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000100477.59081.FE"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-005-2340-8"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000203099.40643.84"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2000.tb00243.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199704000-00009"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17946-X"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2006.12.003"},{"key":"e_1_3_2_10_2","first-page":"51","volume":"27","year":"2006","unstructured":"Wang Y, Cheung PT, Shen GX, Wu EX, Cao G, Bart I, Wong WH, Khong PL. 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