{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:24:59Z","timestamp":1768569899379,"version":"3.49.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Superficial siderosis of the central nervous system results from chronic bleeding in the superficial layers of the cortex and spinal cord. In cerebral amyloid angiopathy (CAA), there is amyloid deposition in meningeal and meningo-cortical arteries and capillaries, predisposing them to rupture. CAA is frequently associated with Alzheimer disease (AD).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods and Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            We report a series of 3 AD patients with MRI evidence of superficial siderosis. Two had neuropathological examination confirming superficial siderosis, AD, and CAA.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Superficial siderosis should be recognized within the spectrum of AD with CAA and considered as a possible antemortem diagnostic feature.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.107.510826","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T02:05:24Z","timestamp":1216346724000},"page":"2894-2897","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":62,"title":["Superficial Siderosis"],"prefix":"10.1161","volume":"39","author":[{"given":"Howard H.","family":"Feldman","sequence":"first","affiliation":[{"name":"From Division of Neurology (H.H.F., J.M., A.W.), Department of Medicine, Division of Neuropathology (I.R.A.M.), Department of Pathology, Department of Radiology (B.B.F.), University of British Columbia, Vancouver, British Columbia, Canada; Department of Neurology (L.F.M.), Hospital Geral Santo Anto\u0301nio, Porto, Portugal."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis F.","family":"Maia","sequence":"additional","affiliation":[{"name":"From Division of Neurology (H.H.F., J.M., A.W.), Department of Medicine, Division of Neuropathology (I.R.A.M.), Department of Pathology, Department of Radiology (B.B.F.), University of British Columbia, Vancouver, British Columbia, Canada; Department of Neurology (L.F.M.), Hospital Geral Santo Anto\u0301nio, Porto, Portugal."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian R.A.","family":"Mackenzie","sequence":"additional","affiliation":[{"name":"From Division of Neurology (H.H.F., J.M., A.W.), Department of Medicine, Division of Neuropathology (I.R.A.M.), Department of Pathology, Department of Radiology (B.B.F.), University of British Columbia, Vancouver, British Columbia, Canada; Department of Neurology (L.F.M.), Hospital Geral Santo Anto\u0301nio, Porto, Portugal."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce B.","family":"Forster","sequence":"additional","affiliation":[{"name":"From Division of Neurology (H.H.F., J.M., A.W.), Department of Medicine, Division of Neuropathology (I.R.A.M.), Department of Pathology, Department of Radiology (B.B.F.), University of British Columbia, Vancouver, British Columbia, Canada; Department of Neurology (L.F.M.), Hospital Geral Santo Anto\u0301nio, Porto, Portugal."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Martzke","sequence":"additional","affiliation":[{"name":"From Division of Neurology (H.H.F., J.M., A.W.), Department of Medicine, Division of Neuropathology (I.R.A.M.), Department of Pathology, Department of Radiology (B.B.F.), University of British Columbia, Vancouver, British Columbia, Canada; Department of Neurology (L.F.M.), Hospital Geral Santo Anto\u0301nio, Porto, Portugal."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Woolfenden","sequence":"additional","affiliation":[{"name":"From Division of Neurology (H.H.F., J.M., A.W.), Department of Medicine, Division of Neuropathology (I.R.A.M.), Department of Pathology, Department of Radiology (B.B.F.), University of British Columbia, Vancouver, British Columbia, Canada; Department of Neurology (L.F.M.), Hospital Geral Santo Anto\u0301nio, Porto, Portugal."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.4.1051"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.7.1498"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh487"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.18.2.3551211"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.3.690"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.4.537"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-005-1064-y"},{"key":"e_1_3_2_8_2","first-page":"1072","volume":"10","year":"1996","unstructured":"Greene JD, Patterson K, Xuereb J, Hodges JR. Alzheimer disease and nonfluent progressive aphasia. Arch Neurol. 1996; 10: 1072\u20131078.","journal-title":"Arch Neurol"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.5.543"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000088665"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.1.135"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.107.510826","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:54:17Z","timestamp":1715604857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.107.510826"}},"subtitle":["A Potential Diagnostic Marker of Cerebral Amyloid Angiopathy in Alzheimer Disease"],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1161\/STROKEAHA.107.510826"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.107.510826","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10]]},"assertion":[{"value":"2007-12-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-01-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-07-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}