{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:58:12Z","timestamp":1785869892231,"version":"3.56.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>Background and Purpose\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Experimental studies suggested neurovascular compression of the brain stem as a cause of hypertension. The aim of our prospective study was to investigate the effect of microvascular decompression in patients with severe hypertension with neurovascular compression on blood pressure and central sympathetic nerve activity in the long-term.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Fourteen patients (4 males; mean age, 46\u00b18 years) with essential hypertension underwent microvascular decompression of the brain stem. Vasoconstrictor muscle sympathetic nerve activity (recorded by microneurography: burst frequency, bursts\/min) and blood pressure (24-hour profiles) were investigated before surgery and 7 days, 3 months, and every 6 months postoperatively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Results\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Muscle sympathetic nerve activity was preoperatively elevated and decreased significantly postoperatively (35\u00b113 bursts\/min vs 20\u00b19 bursts\/min;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01). Sympathetic activity remained reduced 3 months (19\u00b18bursts\/min;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01), 6 months (19\u00b17 bursts\/min;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01), and 12 months (23\u00b19 bursts\/min;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01) postoperatively. However, in the long-term, sympathetic nerve activity increased again (18 months after surgery: 28\u00b110 bursts, not significant; 24 months postoperatively: 34\u00b112 bursts\/min, not significant). Systolic and diastolic blood pressure decreased from 162\u00b16\/98\u00b15 mm Hg preoperatively to 133\u00b16\/85\u00b14 mm Hg (7 days postoperatively;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01); 136\u00b15\/86\u00b14 mm Hg (3 months postoperatively;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01); 132\u00b14\/85\u00b14 mm Hg (6 months postoperatively;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01); 132\u00b13\/85\u00b15 mm Hg (12 months postoperatively;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01); 132\u00b15\/84\u00b15 mm Hg;\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01). Twenty-four months after microvascular decompression, blood pressure increased again up to 158\u00b17\/96\u00b16 mm Hg, corresponding to the sympathetic nerve activity course.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusion\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Sympathetic nerve activity and blood pressure are temporary reduced by microvascular decompression in patients with severe hypertension with neurovascular compression. The data are a hint for sympathetic overactivity as a pathomechanism in this subgroup of patients.\n                  <\/jats:p>","DOI":"10.1161\/strokeaha.108.518670","type":"journal-article","created":{"date-parts":[[2008,10,16]],"date-time":"2008-10-16T21:37:30Z","timestamp":1224193050000},"page":"47-51","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Temporary Reduction of Blood Pressure and Sympathetic Nerve Activity in Hypertensive Patients After Microvascular Decompression"],"prefix":"10.1161","volume":"40","author":[{"given":"Helga","family":"Frank","sequence":"first","affiliation":[{"name":"From Department of Nephrology (H.F.), Klinikum rechts der Isar, Technische Universitaet Muenchen, Germany; Department of Clinical Pharmacology (K.H.), Hannover Medical School, Hannover, Germany; Department of Nephrology (H.G.), University of Frankfurt, Germany; International Neuroscience Institute Hannover (R.F.), Germany; Department of Neurosurgery (R.N.), University of Erlangen-Nuremberg, Germany; Benedictus Krankenhaus Tutzing (H.P.S.), Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Heusser","sequence":"additional","affiliation":[{"name":"From Department of Nephrology (H.F.), Klinikum rechts der Isar, Technische Universitaet Muenchen, Germany; Department of Clinical Pharmacology (K.H.), Hannover Medical School, Hannover, Germany; Department of Nephrology (H.G.), University of Frankfurt, Germany; International Neuroscience Institute Hannover (R.F.), Germany; Department of Neurosurgery (R.N.), University of Erlangen-Nuremberg, Germany; Benedictus Krankenhaus Tutzing (H.P.S.), Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Geiger","sequence":"additional","affiliation":[{"name":"From Department of Nephrology (H.F.), Klinikum rechts der Isar, Technische Universitaet Muenchen, Germany; Department of Clinical Pharmacology (K.H.), Hannover Medical School, Hannover, Germany; Department of Nephrology (H.G.), University of Frankfurt, Germany; International Neuroscience Institute Hannover (R.F.), Germany; Department of Neurosurgery (R.N.), University of Erlangen-Nuremberg, Germany; Benedictus Krankenhaus Tutzing (H.P.S.), Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Fahlbusch","sequence":"additional","affiliation":[{"name":"From Department of Nephrology (H.F.), Klinikum rechts der Isar, Technische Universitaet Muenchen, Germany; Department of Clinical Pharmacology (K.H.), Hannover Medical School, Hannover, Germany; Department of Nephrology (H.G.), University of Frankfurt, Germany; International Neuroscience Institute Hannover (R.F.), Germany; Department of Neurosurgery (R.N.), University of Erlangen-Nuremberg, Germany; Benedictus Krankenhaus Tutzing (H.P.S.), Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Naraghi","sequence":"additional","affiliation":[{"name":"From Department of Nephrology (H.F.), Klinikum rechts der Isar, Technische Universitaet Muenchen, Germany; Department of Clinical Pharmacology (K.H.), Hannover Medical School, Hannover, Germany; Department of Nephrology (H.G.), University of Frankfurt, Germany; International Neuroscience Institute Hannover (R.F.), Germany; Department of Neurosurgery (R.N.), University of Erlangen-Nuremberg, Germany; Benedictus Krankenhaus Tutzing (H.P.S.), Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans P.","family":"Schobel","sequence":"additional","affiliation":[{"name":"From Department of Nephrology (H.F.), Klinikum rechts der Isar, Technische Universitaet Muenchen, Germany; Department of Clinical Pharmacology (K.H.), Hannover Medical School, Hannover, Germany; Department of Nephrology (H.G.), University of Frankfurt, Germany; International Neuroscience Institute Hannover (R.F.), Germany; Department of Neurosurgery (R.N.), University of Erlangen-Nuremberg, Germany; Benedictus Krankenhaus Tutzing (H.P.S.), Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"253","volume":"202","year":"1984","unstructured":"Jannetta PJ, Segal RS, Wolfson SK, Dujovny M, Semba A, Cook EE. 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