{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:26:42Z","timestamp":1791131202544,"version":"4.1.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Inflammation is a major risk factor for atherosclerotic plaque rupture and clinical events. Previous studies have shown that plaque [\n            <jats:sup>18<\/jats:sup>\n            F]fluorodeoxyglucose (FDG) uptake correlates with macrophage content. In this study we examined the reproducibility of 3 methods of quantifying plaque FDG uptake in the carotid arteries using positron emission tomography (PET). The correlation between 2 simplified uptake parameters (standardized uptake value [SUV], vessel wall-to-blood ratio [VBR]) and a gold standard technique (influx rate [K\n            <jats:sub>i<\/jats:sub>\n            ]) was also determined. We used MRI to correct carotid plaque FDG uptake for partial volume error.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            Seven patients with a recent carotid territory transient ischemic attack underwent imaging twice within 8 days using MR and FDG-PET. MR coregistered to PET was used to delineate regions of interest, and to facilitate partial volume correction (PVC).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            SUV was the most reproducible parameter irrespective of whether it was normalized by body surface area (BSA), lean body mass, or weight (intraclass correlation coefficient=0.85, 0.88, and 0.90, respectively). VBR correlated better to K\n            <jats:sub>i<\/jats:sub>\n            than SUV (\n            <jats:italic>r<\/jats:italic>\n            =0.58 VBR,\n            <jats:italic>r<\/jats:italic>\n            =0.46 SUV\n            <jats:sup>BSA<\/jats:sup>\n            ). PVC improved these correlations to\n            <jats:italic>r<\/jats:italic>\n            =0.81 VBR and\n            <jats:italic>r<\/jats:italic>\n            =0.76 SUV\n            <jats:sup>BSA<\/jats:sup>\n            , and only slightly degraded the reproducibility of SUV (intraclass correlation coefficient=0.83\u20130.85).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            MR-guided FDG-PET is a highly reproducible technique in the carotid artery and the excellent anatomic detail provided by MR facilitates PVC. Of the methods examined, SUV\n            <jats:sup>BSA<\/jats:sup>\n            <jats:sub>PVC<\/jats:sub>\n            appears to represent the best compromise between reproducible and accurate determination of FDG metabolism in carotid artery vessel wall.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.108.521393","type":"journal-article","created":{"date-parts":[[2008,10,17]],"date-time":"2008-10-17T01:37:30Z","timestamp":1224207450000},"page":"86-93","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":102,"title":["Comparison of Methods for Magnetic Resonance-Guided [18-F]Fluorodeoxyglucose Positron Emission Tomography in Human Carotid Arteries"],"prefix":"10.1161","volume":"40","author":[{"given":"David","family":"Izquierdo-Garcia","sequence":"first","affiliation":[{"name":"From Wolfson Brain Imaging Centre (D.I.-G., T.D.F.), Division of Cardiovascular Medicine (J.R.D., J.H.F.R., P.L.W.), Department of Radiology (M.J.G., J.H.G.), Clinical Neurosciences (E.A.W.), University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Davies","sequence":"additional","affiliation":[{"name":"From Wolfson Brain Imaging Centre (D.I.-G., T.D.F.), Division of Cardiovascular Medicine (J.R.D., J.H.F.R., P.L.W.), Department of Radiology (M.J.G., J.H.G.), Clinical Neurosciences (E.A.W.), University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Graves","sequence":"additional","affiliation":[{"name":"From Wolfson Brain Imaging Centre (D.I.-G., T.D.F.), Division of Cardiovascular Medicine (J.R.D., J.H.F.R., P.L.W.), Department of Radiology (M.J.G., J.H.G.), Clinical Neurosciences (E.A.W.), University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James H.F.","family":"Rudd","sequence":"additional","affiliation":[{"name":"From Wolfson Brain Imaging Centre (D.I.-G., T.D.F.), Division of Cardiovascular Medicine (J.R.D., J.H.F.R., P.L.W.), Department of Radiology (M.J.G., J.H.G.), Clinical Neurosciences (E.A.W.), University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Gillard","sequence":"additional","affiliation":[{"name":"From Wolfson Brain Imaging Centre (D.I.-G., T.D.F.), Division of Cardiovascular Medicine (J.R.D., J.H.F.R., P.L.W.), Department of Radiology (M.J.G., J.H.G.), Clinical Neurosciences (E.A.W.), University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"Weissberg","sequence":"additional","affiliation":[{"name":"From Wolfson Brain Imaging Centre (D.I.-G., T.D.F.), Division of Cardiovascular Medicine (J.R.D., J.H.F.R., P.L.W.), Department of Radiology (M.J.G., J.H.G.), Clinical Neurosciences (E.A.W.), University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim D.","family":"Fryer","sequence":"additional","affiliation":[{"name":"From Wolfson Brain Imaging Centre (D.I.-G., T.D.F.), Division of Cardiovascular Medicine (J.R.D., J.H.F.R., P.L.W.), Department of Radiology (M.J.G., J.H.G.), Clinical Neurosciences (E.A.W.), University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Warburton","sequence":"additional","affiliation":[{"name":"From Wolfson Brain Imaging Centre (D.I.-G., T.D.F.), Division of Cardiovascular Medicine (J.R.D., J.H.F.R., P.L.W.), Department of Radiology (M.J.G., J.H.G.), Clinical Neurosciences (E.A.W.), University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.53.4.363"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.94.8.2013"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.29.8.1625"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(86)80455-7"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2006.00045.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000020548.60110.76"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000190896.67743.b1"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nuclcard.2005.03.002"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.05.076"},{"key":"e_1_3_2_10_2","first-page":"1845","volume":"47","year":"2006","unstructured":"Ogawa M, Magata Y, Kato T, Hatano K, Ishino S, Mukai T, Shiomi M, Ito K, Saji H. 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