{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:28:38Z","timestamp":1784014118956,"version":"3.55.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Noninvasive screening for intracranial in-stent stenosis is often limited by artifact because of the stent or associated coils. We aimed to determine the utility of quantitative MRA (QMRA) as a screening tool for detecting intracranial in-stent stenosis.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            We reviewed 14 patients who had intracranial stent placement with follow-up QMRA and conventional angiography at our institution. Socio-demographic, medical, clinical, and imaging data were abstracted from medical charts. A blinded interventional neurologist reviewed all angiograms for presence of &gt;50% in-stent stenosis. We tested QMRA (mL\/min) at varying thresholds as a predictor of angiographic results.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Among 14 patients (mean age, 62 years; 12 female, 2 male), 13 patients had Neuroform stents placed for wide-neck cerebral aneurysms and 1 patient had a Wingspan stent placement for atherosclerotic stenosis. Lesions were located in the intracranial internal carotid artery in 57.2% (n=8), the middle cerebral artery in 14.3% (n=2), and vertebrobasilar arteries in 28.6% (n=4). On follow-up angiography, 2 patients (14.3%) had &gt;50% in-stent stenosis on angiography. Time-of-flight MRA was nondiagnostic in each case because of artifact from the stent or coils. A &gt;20% reduction in vessel-specific blood flow by QMRA was associated with presence of &gt;50% in-stent stenosis on angiography (\n            <jats:italic>P<\/jats:italic>\n            =0.033). As a screening tool to predict &gt;50% angiographic in-stent stenosis, the sensitivity, specificity, positive predictive value, and negative predictive value of QMRA were 100%, 92%, 67%, and 100%, respectively.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion\u2014<\/jats:italic>\n            <\/jats:bold>\n            We found that QMRA is a promising screening tool to detect intracranial in-stent stenosis. Future prospective studies should focus on whether QMRA has a role in the detection of radiographic restenosis and prediction of clinical events.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.108.522391","type":"journal-article","created":{"date-parts":[[2009,1,23]],"date-time":"2009-01-23T02:53:46Z","timestamp":1232679226000},"page":"991-993","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["The Utility of Quantitative Magnetic Resonance Angiography in the Assessment of Intracranial In-Stent Stenosis"],"prefix":"10.1161","volume":"40","author":[{"given":"Shyam","family":"Prabhakaran","sequence":"first","affiliation":[{"name":"From Department of Neurological Sciences (S.P., L.W., M.C.), Neurosurgery (K.R.W., D.K.L.), and Radiology (M.D.J.), Rush University Medical Center, Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Warrior","sequence":"additional","affiliation":[{"name":"From Department of Neurological Sciences (S.P., L.W., M.C.), Neurosurgery (K.R.W., D.K.L.), and Radiology (M.D.J.), Rush University Medical Center, Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalani R.","family":"Wells","sequence":"additional","affiliation":[{"name":"From Department of Neurological Sciences (S.P., L.W., M.C.), Neurosurgery (K.R.W., D.K.L.), and Radiology (M.D.J.), Rush University Medical Center, Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miral D.","family":"Jhaveri","sequence":"additional","affiliation":[{"name":"From Department of Neurological Sciences (S.P., L.W., M.C.), Neurosurgery (K.R.W., D.K.L.), and Radiology (M.D.J.), Rush University Medical Center, Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Chen","sequence":"additional","affiliation":[{"name":"From Department of Neurological Sciences (S.P., L.W., M.C.), Neurosurgery (K.R.W., D.K.L.), and Radiology (M.D.J.), Rush University Medical Center, Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrius K.","family":"Lopes","sequence":"additional","affiliation":[{"name":"From Department of Neurological Sciences (S.P., L.W., M.C.), Neurosurgery (K.R.W., D.K.L.), and Radiology (M.D.J.), Rush University Medical Center, Chicago, Ill."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000219853.56553.71"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000290914.24976.83"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-007-0252-y"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0582"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000166195.63276.7c"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2007.106.2.291"},{"key":"e_1_3_2_7_2","first-page":"E14.","volume":"24","year":"2008","unstructured":"Brisman JL. Wingspan stenting of symptomatic extracranial vertebral artery stenosis and perioperative evaluation using quantitative magnetic resonance angiography: Report of two cases. Neurosurg Focus. 2008; 24: E14.","journal-title":"Neurosurg Focus"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20642"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0713"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.108.522391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T13:05:54Z","timestamp":1715605554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.108.522391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1161\/STROKEAHA.108.522391"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.108.522391","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3]]},"assertion":[{"value":"2008-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-06-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-01-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}