{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:45:41Z","timestamp":1778280341008,"version":"3.51.4"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Reocclusion of intracranial arteries after successful recanalization is associated with poor clinical outcome. The role of Factor V Leiden mutation in intracranial arterial thrombosis\/rethrombosis is unclear.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Summary of Report\u2014<\/jats:italic>\n            <\/jats:bold>\n            We report the case of a patient who developed recurrent reocclusions of the middle cerebral artery after intra-arterial thrombolysis for acute ischemic stroke. The patient subsequently underwent transcatheter clot retrieval followed by successful stent-supported angioplasty of the occluded segment. He underwent a detailed workup for thrombophilia. The patient was detected to be heterozygous for Factor V Leiden mutation without any other cause for thrombophilia.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Factor V Leiden mutation could be a contributing etiology for reocclusion after endovascular interventions in stroke. Systematic studies looking for thrombophilic mutations in patients with arterial reocclusion might be warranted.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.108.522771","type":"journal-article","created":{"date-parts":[[2008,10,17]],"date-time":"2008-10-17T01:37:30Z","timestamp":1224207450000},"page":"660-662","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Factor V Leiden Mutation in Reocclusion After Intra-Arterial Thrombolysis"],"prefix":"10.1161","volume":"40","author":[{"given":"Abraham","family":"Kuruvilla","sequence":"first","affiliation":[{"name":"From the WSU\/DMC Comprehensive Stroke Program, Department of Neurology (A.K., G.M.N., A.R.X., S.C.) and the Department of Neurosurgery (S.M., A.R.X.), Wayne State University School of Medicine, Detroit, Mich, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory M.","family":"Norris","sequence":"additional","affiliation":[{"name":"From the WSU\/DMC Comprehensive Stroke Program, Department of Neurology (A.K., G.M.N., A.R.X., S.C.) and the Department of Neurosurgery (S.M., A.R.X.), Wayne State University School of Medicine, Detroit, Mich, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Manjila","sequence":"additional","affiliation":[{"name":"From the WSU\/DMC Comprehensive Stroke Program, Department of Neurology (A.K., G.M.N., A.R.X., S.C.) and the Department of Neurosurgery (S.M., A.R.X.), Wayne State University School of Medicine, Detroit, Mich, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew R.","family":"Xavier","sequence":"additional","affiliation":[{"name":"From the WSU\/DMC Comprehensive Stroke Program, Department of Neurology (A.K., G.M.N., A.R.X., S.C.) and the Department of Neurosurgery (S.M., A.R.X.), Wayne State University School of Medicine, Detroit, Mich, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seemant","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"From the WSU\/DMC Comprehensive Stroke Program, Department of Neurology (A.K., G.M.N., A.R.X., S.C.) and the Department of Neurosurgery (S.M., A.R.X.), Wayne State University School of Medicine, Detroit, Mich, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0825"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.32.3.661"},{"key":"e_1_3_2_3_2","first-page":"322","volume":"25","year":"2004","unstructured":"Qureshi AI, Siddiqui AM, Kim SH, Hanel RA, Xavier AR, Kirmani JF, Suri MFK, Boulos AS, Hopkins LN. Reocclusion of recanalized arteries during intra-arterial thrombolysis for acute ischemic stroke. AJNR Am J Neuroradiol. 2004; 25: 322\u2013328.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-10-199711150-00007"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000083049.65008.5f"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000258076.04860.8e"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.106.480863"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504063321403"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615092"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/1076029606298999"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.2310\/6670.2008.00007"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2006.02.014"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.108.522771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:27:06Z","timestamp":1715603226000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.108.522771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1161\/STROKEAHA.108.522771"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.108.522771","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"2008-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-05-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-10-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}