{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:35:08Z","timestamp":1792704908248,"version":"4.5.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>Background and Purpose\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    While intravenous recombinant tissue plasminogen activator (rt-PA) has been approved for acute stroke therapy within 3 hours, the optimum management of basilar artery occlusion (BAO) is still a matter of debate. We compared intraarterial thrombolysis with the combined bridging approach of intravenous abciximab and intraarterial thrombolysis with rt-PA (bridging therapy) in an observational, longitudinal, monocenter study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Between 1998 and 2006, information for 106 patients with acute BAO were prospectively entered into a local database. Patients eligible for treatment received either intraarterial thrombolysis with rt-PA alone (intraarterial thrombolysis) or were treated with intravenous abciximab and intraarterial rt-PA (bridging therapy). Outcome parameters were recanalization of the basilar artery according to Trial in Myocardial Infarction criteria, survival, and reduction of severe disability and death at 3 months. Logistic regression was used to identify independent predictors for recanalization, survival, and clinical outcome.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Results\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Of a total of 106 patients with confirmed BAO, 87 patients underwent subsequent angiography. Among those, 75 patients were identified who received the full treatment protocol. Patients in the bridging group had a better recanalization rate (83.7% vs 62.5%;\n                    <jats:italic>P<\/jats:italic>\n                    =0.03), a higher survival rate (58.1% vs 25%;\n                    <jats:italic>P<\/jats:italic>\n                    =0.01), and a better chance for an outcome with no or only mild to moderate disability (modified Rankin Scale score, 0\u20133; 34.9% vs 12.5%;\n                    <jats:italic>P<\/jats:italic>\n                    =0.02). Symptomatic intracerebral hemorrhage rates were comparable in both groups (14% in the bridging group vs 18.8%;\n                    <jats:italic>P<\/jats:italic>\n                    =0.41). Independent predictors for recanalization were age (OR, 0.95; 95% CI, 0.91\u20130.99), atrial fibrillation (OR, 6.53; 95% CI, 1.14\u201337.49), and bridging therapy (OR, 3.37; 95% CI, 1.02 to 11.18). Independent prognostic factors for outcome were Glasgow coma scale score at presentation (OR, 1.24; 95% CI, 1.03\u20131.45) and the combination of bridging therapy with successful recanalization (OR, 3.744; 95% CI, 1.04\u201313.43).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusion\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Bridging therapy for acute BAO with intravenous abciximab and intraarterial rt-PA appears to be safe and yields higher recanalization and improved survival rates, as well as an overall improved chance for a better outcome.\n                  <\/jats:p>","DOI":"10.1161\/strokeaha.108.526566","type":"journal-article","created":{"date-parts":[[2008,10,16]],"date-time":"2008-10-16T21:37:30Z","timestamp":1224193050000},"page":"140-146","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":94,"title":["Therapy of Acute Basilar Artery Occlusion"],"prefix":"10.1161","volume":"40","author":[{"given":"Simon","family":"Nagel","sequence":"first","affiliation":[{"name":"From Department of Neurology (S.N., E.J., P.R.), University of Heidelberg, Medical School, Germany; Department of Neurology (P.D.S., H.B.H., S.S., M.K.), University of Erlangen, Medical School, Germany; Department of Neuroradiology (M.H., E.J.), University of Heidelberg, Medical School, Germany; Acute Stroke Programme (S.N.), Nuffield Department of Clinical Medicine, University of Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter D.","family":"Schellinger","sequence":"additional","affiliation":[{"name":"From Department of Neurology (S.N., E.J., P.R.), University of Heidelberg, Medical School, Germany; Department of Neurology (P.D.S., H.B.H., S.S., M.K.), University of Erlangen, Medical School, Germany; Department of Neuroradiology (M.H., E.J.), University of Heidelberg, Medical School, Germany; Acute Stroke Programme (S.N.), Nuffield Department of Clinical Medicine, University of Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Hartmann","sequence":"additional","affiliation":[{"name":"From Department of Neurology (S.N., E.J., P.R.), University of Heidelberg, Medical School, Germany; Department of Neurology (P.D.S., H.B.H., S.S., M.K.), University of Erlangen, Medical School, Germany; Department of Neuroradiology (M.H., E.J.), University of Heidelberg, Medical School, Germany; Acute Stroke Programme (S.N.), Nuffield Department of Clinical Medicine, University of Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Juettler","sequence":"additional","affiliation":[{"name":"From Department of Neurology (S.N., E.J., P.R.), University of Heidelberg, Medical School, Germany; Department of Neurology (P.D.S., H.B.H., S.S., M.K.), University of Erlangen, Medical School, Germany; Department of Neuroradiology (M.H., E.J.), University of Heidelberg, Medical School, Germany; Acute Stroke Programme (S.N.), Nuffield Department of Clinical Medicine, University of Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagen B.","family":"Huttner","sequence":"additional","affiliation":[{"name":"From Department of Neurology (S.N., E.J., P.R.), University of Heidelberg, Medical School, Germany; Department of Neurology (P.D.S., H.B.H., S.S., M.K.), University of Erlangen, Medical School, Germany; Department of Neuroradiology (M.H., E.J.), University of Heidelberg, Medical School, Germany; Acute Stroke Programme (S.N.), Nuffield Department of Clinical Medicine, University of Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ringleb","sequence":"additional","affiliation":[{"name":"From Department of Neurology (S.N., E.J., P.R.), University of Heidelberg, Medical School, Germany; Department of Neurology (P.D.S., H.B.H., S.S., M.K.), University of Erlangen, Medical School, Germany; Department of Neuroradiology (M.H., E.J.), University of Heidelberg, Medical School, Germany; Acute Stroke Programme (S.N.), Nuffield Department of Clinical Medicine, University of Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schwab","sequence":"additional","affiliation":[{"name":"From Department of Neurology (S.N., E.J., P.R.), University of Heidelberg, Medical School, Germany; Department of Neurology (P.D.S., H.B.H., S.S., M.K.), University of Erlangen, Medical School, Germany; Department of Neuroradiology (M.H., E.J.), University of Heidelberg, Medical School, Germany; Acute Stroke Programme (S.N.), Nuffield Department of Clinical Medicine, University of Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ko\u0308hrmann","sequence":"additional","affiliation":[{"name":"From Department of Neurology (S.N., E.J., P.R.), University of Heidelberg, Medical School, Germany; Department of Neurology (P.D.S., H.B.H., S.S., M.K.), University of Erlangen, Medical School, Germany; Department of Neuroradiology (M.H., E.J.), University of Heidelberg, Medical School, Germany; Acute Stroke Programme (S.N.), Nuffield Department of Clinical Medicine, University of Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.21.8.2389292"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000202582.29510.6b"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000237069.89438.a9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.27.5.875"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000014247.70674.7f"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198510173131611"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000072554"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.485649"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000165918.80812.1e"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2007.00145.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.19.10.3176080"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000086121"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000237211.84743.d8"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000237210.15986.d6"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.106.465567"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000251439.50090.0c"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000254128.05122.a2"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000237127.84408.c0"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000251686.28701.17"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000247897.33267.42"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.106.474908"},{"key":"e_1_3_2_22_2","first-page":"CD005208.","year":"2006","unstructured":"Ciccone A, Abraha I, Santilli I. Glycoprotein IIb-IIIa inhibitors for acute ischaemic stroke. Cochrane Database Syst Rev. 2006: CD005208.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_2_23_2","first-page":"1","volume":"28","year":"1991","unstructured":"Caplan LR. Vertebrobasilar embolism. Clin Exp Neurol. 1991; 28: 1\u201322.","journal-title":"Clin Exp Neurol"},{"key":"e_1_3_2_24_2","first-page":"1221","volume":"18","year":"1997","unstructured":"Cross DT III, Moran CJ, Akins PT, Angtuaco EE, Diringer MN. Relationship between clot location and outcome after basilar artery thrombolysis. AJNR Am J Neuroradiol. 1997; 18: 1221\u20131228.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_2_25_2","first-page":"2042","volume":"27","year":"2006","unstructured":"Schulte-Altedorneburg G, Hamann GF, Mull M, Kuhne D, Liebetrau M, Weber W, Bruckmann H, Mayer TE. Outcome of acute vertebrobasilar occlusions treated with intra-arterial fibrinolysis in 180 patients. AJNR Am J Neuroradiol. 2006; 27: 2042\u20132047.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199909000-00025"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.020479"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000157662.09551.e5"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000260089.17105.27"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.108.526566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T08:46:56Z","timestamp":1715590016000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.108.526566"}},"subtitle":["Intraarterial Thrombolysis Alone vs Bridging Therapy"],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1161\/STROKEAHA.108.526566"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.108.526566","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1158235.618360","asserted-by":"object"}]},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1]]},"assertion":[{"value":"2008-05-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-06-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-10-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}