{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:21:45Z","timestamp":1791919305164,"version":"4.3.4"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2009,2]]},"abstract":"\n \n Background and Purpose\u2014<\/jats:italic>\n <\/jats:bold>\n We sought to determine if patients with intracranial stenosis who have a transient ischemic attack or stroke on antithrombotic therapy are at particularly high risk for recurrent stroke.\n <\/jats:p>\n \n \n Methods\u2014<\/jats:italic>\n <\/jats:bold>\n We compared baseline features and the rates of stroke or vascular death and stroke in the territory of the symptomatic artery between patients ON (n=299) versus OFF (n=269) antithrombotics at the time of their qualifying event for the Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) trial.\n <\/jats:p>\n \n \n Results\u2014<\/jats:italic>\n <\/jats:bold>\n In univariate analyses, there was no difference in the rates of stroke or vascular death (21% versus 23%; hazard ratio [ON\/OFF], 0.91; 95% CI, 0.64 to 1.29;\n P<\/jats:italic>\n =0.59) or stroke in territory (13% versus 14%; hazard ratio [ON\/OFF], 0.90; 95% CI, 0.57 to 1.39;\n P<\/jats:italic>\n =0.61) between patients ON versus OFF antithrombotics at the time of their qualifying event. A multivariable analysis adjusted for the difference in risk factors between patients ON and OFF antithrombotic therapy also showed no significant differences in the combined end point of stroke or vascular death (hazard ratio [ON\/OFF], 0.86; 95% CI, 0.55 to 1.34;\n P<\/jats:italic>\n =0.51) or stroke in territory (hazard ratio [ON\/OFF], 1.01; 95% CI, 0.58 to 1.77;\n P<\/jats:italic>\n =0.97) between patients ON versus OFF antithrombotic therapy at the time of the qualifying event.\n <\/jats:p>\n \n \n Conclusions\u2014<\/jats:italic>\n <\/jats:bold>\n Patients with intracranial stenosis who fail antithrombotic therapy are not at higher risk of stroke than those who do not fail antithrombotic therapy. Given our finding that patients ON and OFF antithrombotic therapy are both at high risk for stroke in the territory, intracranial stenting trials should not be limited to just those who fail antithrombotic therapy.\n <\/jats:p>","DOI":"10.1161\/strokeaha.108.528281","type":"journal-article","created":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T02:40:49Z","timestamp":1229654449000},"page":"505-509","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":49,"title":["Failure of Antithrombotic Therapy and Risk of Stroke in Patients With Symptomatic Intracranial Stenosis"],"prefix":"10.1161","volume":"40","author":[{"given":"Tanya N.","family":"Turan","sequence":"first","affiliation":[{"name":"From the Medical University of South Carolina (T.N.T., M.I.C.), Charleston, SC; Emory University (L.M., G.C., M.J.L.), Atlanta, Ga; the University of Miami (J.G.R.), Miami, Fla; and Mount Sinai School of Medicine (S.R.L.), New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucian","family":"Maidan","sequence":"additional","affiliation":[{"name":"From the Medical University of South Carolina (T.N.T., M.I.C.), Charleston, SC; Emory University (L.M., G.C., M.J.L.), Atlanta, Ga; the University of Miami (J.G.R.), Miami, Fla; and Mount Sinai School of Medicine (S.R.L.), New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Cotsonis","sequence":"additional","affiliation":[{"name":"From the Medical University of South Carolina (T.N.T., M.I.C.), Charleston, SC; Emory University (L.M., G.C., M.J.L.), Atlanta, Ga; the University of Miami (J.G.R.), Miami, Fla; and Mount Sinai School of Medicine (S.R.L.), New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Lynn","sequence":"additional","affiliation":[{"name":"From the Medical University of South Carolina (T.N.T., M.I.C.), Charleston, SC; Emory University (L.M., G.C., M.J.L.), Atlanta, Ga; the University of Miami (J.G.R.), Miami, Fla; and Mount Sinai School of Medicine (S.R.L.), New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose G.","family":"Romano","sequence":"additional","affiliation":[{"name":"From the Medical University of South Carolina (T.N.T., M.I.C.), Charleston, SC; Emory University (L.M., G.C., M.J.L.), Atlanta, Ga; the University of Miami (J.G.R.), Miami, Fla; and Mount Sinai School of Medicine (S.R.L.), New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Levine","sequence":"additional","affiliation":[{"name":"From the Medical University of South Carolina (T.N.T., M.I.C.), Charleston, SC; Emory University (L.M., G.C., M.J.L.), Atlanta, Ga; the University of Miami (J.G.R.), Miami, Fla; and Mount Sinai School of Medicine (S.R.L.), New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc I.","family":"Chimowitz","sequence":"additional","affiliation":[{"name":"From the Medical University of South Carolina (T.N.T., M.I.C.), Charleston, SC; Emory University (L.M., G.C., M.J.L.), Atlanta, Ga; the University of Miami (J.G.R.), Miami, Fla; and Mount Sinai School of Medicine (S.R.L.), New York, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.26.1.14"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043033"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.4.490"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000068744"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/80.3.557"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011258"},{"key":"e_1_3_3_7_2","unstructured":"Mohr JP. Evidence of aspirin and warfarin failure in the WARSS Study. Platform presentation at 27th International Stroke Conference; San Antonio TX; February 2002."},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.106.477711"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.578229"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.108.528281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:23:12Z","timestamp":1715602992000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.108.528281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["10.1161\/STROKEAHA.108.528281"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.108.528281","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2]]},"assertion":[{"value":"2008-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-06-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}