{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:20:41Z","timestamp":1790637641673,"version":"4.1.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>Background and Purpose\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Women who develop pre-eclampsia in pregnancy are at increased risk of cardiovascular disease. The offspring from pregnancies complicated by pre-eclampsia have higher blood pressures during childhood, but little is known about their long-term health. We hypothesized that pre-eclampsia would lead to an increased risk of cardiovascular disease in the offspring.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    We traced 6410 babies born in Helsinki, Finland, from 1934 to 1944. We used the mothers\u2019 blood pressure levels and the presence of proteinuria during pregnancy to define pre-eclampsia and gestational hypertension without proteinuria according to modern criteria.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Results\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Two hundred eighty-four of the pregnancies were complicated by pre-eclampsia (120 with nonsevere and 164 with severe disease) and 1592 by gestational hypertension. The crude hazard ratio for all forms of stroke among people whose mothers had pre-eclampsia was 1.9 (1.2 to 3.0;\n                    <jats:italic>P<\/jats:italic>\n                    =0.01); among people whose mothers had gestational hypertension, it was 1.4 (1.0 to 1.8;\n                    <jats:italic>P<\/jats:italic>\n                    =0.03). There was no evidence that these pregnancy disorders were associated with coronary heart disease in the offspring. Pre-eclampsia, in particular severe disease, was associated with a reduced mean head circumference at birth, whereas gestational hypertension was associated with an increased head circumference in relation to body length.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusions\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    People born after pregnancies complicated by pre-eclampsia or gestational hypertension are at increased risk of stroke. The underlying processes may include a local disorder of the blood vessels of the brain as a consequence of either reduced brain growth or impaired brain growth leading to \u201cbrain-sparing\u201d responses in utero.\n                  <\/jats:p>","DOI":"10.1161\/strokeaha.108.538025","type":"journal-article","created":{"date-parts":[[2009,3,6]],"date-time":"2009-03-06T00:09:27Z","timestamp":1236298167000},"page":"1176-1180","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":395,"title":["Pre-Eclampsia Is Associated With Increased Risk of Stroke in the Adult Offspring"],"prefix":"10.1161","volume":"40","author":[{"given":"Eero","family":"Kajantie","sequence":"first","affiliation":[{"name":"From the Institute for Health and Welfare (E.K., J.G.E.), Department of Chronic Disease Prevention, Helsinki, Finland; the Department of General Practice and Primary Health Care (J.G.E.), University of Helsinki, Helsinki, Finland; MRC Epidemiology Resource Centre (University of Southampton; C.O., D.J.P.B.), Southampton General Hospital, Southampton, UK; and the Heart Research Center (K.T., D.J.P.B.), Oregon Health and Science University, Portland, Ore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan G.","family":"Eriksson","sequence":"additional","affiliation":[{"name":"From the Institute for Health and Welfare (E.K., J.G.E.), Department of Chronic Disease Prevention, Helsinki, Finland; the Department of General Practice and Primary Health Care (J.G.E.), University of Helsinki, Helsinki, Finland; MRC Epidemiology Resource Centre (University of Southampton; C.O., D.J.P.B.), Southampton General Hospital, Southampton, UK; and the Heart Research Center (K.T., D.J.P.B.), Oregon Health and Science University, Portland, Ore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Osmond","sequence":"additional","affiliation":[{"name":"From the Institute for Health and Welfare (E.K., J.G.E.), Department of Chronic Disease Prevention, Helsinki, Finland; the Department of General Practice and Primary Health Care (J.G.E.), University of Helsinki, Helsinki, Finland; MRC Epidemiology Resource Centre (University of Southampton; C.O., D.J.P.B.), Southampton General Hospital, Southampton, UK; and the Heart Research Center (K.T., D.J.P.B.), Oregon Health and Science University, Portland, Ore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent","family":"Thornburg","sequence":"additional","affiliation":[{"name":"From the Institute for Health and Welfare (E.K., J.G.E.), Department of Chronic Disease Prevention, Helsinki, Finland; the Department of General Practice and Primary Health Care (J.G.E.), University of Helsinki, Helsinki, Finland; MRC Epidemiology Resource Centre (University of Southampton; C.O., D.J.P.B.), Southampton General Hospital, Southampton, UK; and the Heart Research Center (K.T., D.J.P.B.), Oregon Health and Science University, Portland, Ore."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.P.","family":"Barker","sequence":"additional","affiliation":[{"name":"From the Institute for Health and Welfare (E.K., J.G.E.), Department of Chronic Disease Prevention, Helsinki, Finland; the Department of General Practice and Primary Health Care (J.G.E.), University of Helsinki, Helsinki, Finland; MRC Epidemiology Resource Centre (University of Southampton; C.O., D.J.P.B.), Southampton General Hospital, Southampton, UK; and the Heart Research Center (K.T., D.J.P.B.), Oregon Health and Science University, Portland, Ore."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","first-page":"446","volume":"124","year":"1975","unstructured":"Chesley LC, Annitto JE, Cosgrove RA. 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