{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:12:57Z","timestamp":1792203177583,"version":"4.4.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Little is known about the gender-specific manifestations of cerebral venous and sinus thrombosis, a disease that is much more common in women than men.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            We used data of the International Study on Cerebral Vein and Dural sinus Thrombosis (ISCVT), a multicenter prospective observational study, to analyze gender-specific differences in clinical presentation, etiology, and outcome of cerebral venous thrombosis.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Four hundred sixty-five of a total of 624 patients were women (75%). Women were significantly younger, had less often a chronic onset of symptoms, and had more often headache at presentation. There were no gender differences in ancillary investigations or treatment. A gender-specific risk factor (oral contraceptives, pregnancy, puerperium, and hormonal replacement therapy) was present in 65% of women. Women had a better prognosis than men (complete recovery 81% versus 71%l\n            <jats:italic>P<\/jats:italic>\n            =0.01), which was entirely due to a better outcome in female patients with gender-specific risk factors. Women without gender-specific risk factors are similar to men in clinical presentation, risk factor profile, and outcome. Logistic regression analysis confirmed that the absence of gender-specific risk factors is a strong and independent predictor of poor outcome in women with sinus thrombosis (OR, 3.7; CI, 1.9 to 7.4).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Our study identified important differences between women and men in presentation, course, and risk factors of cerebral venous and sinus thrombosis and showed that women with a gender-specific risk factor have a much better prognosis than other patients.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.108.543884","type":"journal-article","created":{"date-parts":[[2009,5,29]],"date-time":"2009-05-29T02:00:16Z","timestamp":1243562416000},"page":"2356-2361","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":339,"title":["Cerebral Venous and Sinus Thrombosis in Women"],"prefix":"10.1161","volume":"40","author":[{"given":"Jonathan M.","family":"Coutinho","sequence":"first","affiliation":[{"name":"From the Department of Neurology (J.M.C., J.S.), Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; the Department of Neurosciences (J.M.F., P.C.), Hospital Santa Maria, Lisboa, Portugal; the Department of Neurology (F.B., C.C.), Instituto Nacional de Neurologia y Neurocirurgia, Me\u0301xico City, Me\u0301xico; and the Department of Neurology (M.-G.B.), Ho\u0302pital Lariboisie\u0300re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u0301 M.","family":"Ferro","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (J.M.C., J.S.), Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; the Department of Neurosciences (J.M.F., P.C.), Hospital Santa Maria, Lisboa, Portugal; the Department of Neurology (F.B., C.C.), Instituto Nacional de Neurologia y Neurocirurgia, Me\u0301xico City, Me\u0301xico; and the Department of Neurology (M.-G.B.), Ho\u0302pital Lariboisie\u0300re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patri\u0301cia","family":"Canha\u0303o","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (J.M.C., J.S.), Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; the Department of Neurosciences (J.M.F., P.C.), Hospital Santa Maria, Lisboa, Portugal; the Department of Neurology (F.B., C.C.), Instituto Nacional de Neurologia y Neurocirurgia, Me\u0301xico City, Me\u0301xico; and the Department of Neurology (M.-G.B.), Ho\u0302pital Lariboisie\u0300re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Barinagarrementeria","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (J.M.C., J.S.), Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; the Department of Neurosciences (J.M.F., P.C.), Hospital Santa Maria, Lisboa, Portugal; the Department of Neurology (F.B., C.C.), Instituto Nacional de Neurologia y Neurocirurgia, Me\u0301xico City, Me\u0301xico; and the Department of Neurology (M.-G.B.), Ho\u0302pital Lariboisie\u0300re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cantu\u0301","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (J.M.C., J.S.), Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; the Department of Neurosciences (J.M.F., P.C.), Hospital Santa Maria, Lisboa, Portugal; the Department of Neurology (F.B., C.C.), Instituto Nacional de Neurologia y Neurocirurgia, Me\u0301xico City, Me\u0301xico; and the Department of Neurology (M.-G.B.), Ho\u0302pital Lariboisie\u0300re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Germaine","family":"Bousser","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (J.M.C., J.S.), Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; the Department of Neurosciences (J.M.F., P.C.), Hospital Santa Maria, Lisboa, Portugal; the Department of Neurology (F.B., C.C.), Instituto Nacional de Neurologia y Neurocirurgia, Me\u0301xico City, Me\u0301xico; and the Department of Neurology (M.-G.B.), Ho\u0302pital Lariboisie\u0300re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Stam","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (J.M.C., J.S.), Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; the Department of Neurosciences (J.M.F., P.C.), Hospital Santa Maria, Lisboa, Portugal; the Department of Neurology (F.B., C.C.), Instituto Nacional de Neurologia y Neurocirurgia, Me\u0301xico City, Me\u0301xico; and the Department of Neurology (M.-G.B.), Ho\u0302pital Lariboisie\u0300re, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra042354"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(07)70029-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000117571.76197.26"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7131.589"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199806183382502"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3578"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200108093450604"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000177894.05495.54"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/neurosurgery\/14.CN_suppl_1.1"},{"key":"e_1_3_2_10_2","first-page":"225","volume":"92","year":"2003","unstructured":"Stam J. Cerebral venous and sinus thrombosis: incidence and causes. Adv Neurol. 2003; 92: 225\u2013232.","journal-title":"Adv Neurol"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000068410.07397.d7"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000083534.81284.c5"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050613"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000236053.37695.15"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.24.12.8248971"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.10.6.524408"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2004.06.002"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.512814"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01398.x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007063430102"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-004-0287-3"},{"key":"e_1_3_2_22_2","first-page":"e1","volume":"36","year":"2005","unstructured":"Tentschert S, Wimmer R, Greisenegger S, Lang W, Lalouschek W. Headache at stroke onset in 2196 patients with ischemic stroke or transient ischemic attack. Stroke. 2005; 36: e1\u2013e3.","journal-title":"Stroke"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10266-0"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90286-0"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.108.543884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T12:17:58Z","timestamp":1715602678000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.108.543884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["10.1161\/STROKEAHA.108.543884"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.108.543884","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7]]},"assertion":[{"value":"2008-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-03-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}