{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:13Z","timestamp":1790812813936,"version":"4.1.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>Background and Purpose\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    The aim of this study was to identify quantitative trait loci (QTL) for carotid intima-media thickness (CIMT) a risk factor for stroke and cardiovascular disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Probands were selected from Caribbean Hispanic subjects of the population-based Northern Manhattan Study. CIMT was measured by high-resolution B-mode ultrasound and expressed as the mean (IMTx) and mean of the maximum (IMTm). Variance components methodology was used to detect linkage using SOLAR and calculate locus-specific heritability. Ordered-subset Analysis was done based on history of hypertension and total cholesterol levels.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Results\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Among 100 Dominican families, 1390 subjects had CIMT measured (848 females; mean age 46.2 years). CIMT had a heritability of 0.65 after adjusting for age, age\n                    <jats:sup>2<\/jats:sup>\n                    , sex, cigarette pack-years, waist hip ratio, and BMI. Adjusted maximum multipoint LOD scores &gt;2 were found on chromosomes 14q (D14S606) and 7p (D7S817). Linkage to chromosome 14q was significantly increased in a subset of families with the greatest history of hypertension (MLOD=4.12). The QTL on Ch14q accounted for 0.21 of the heritability of IMTm, and on Ch7p 0.27 of the heritability of BIFm.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusions\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Several QTLs for CIMT were found on chromosomes 7p and 14q. The QTL on 14q replicates a suggestive linkage peak delimited in the Framingham Heart Study. These QTLs accounted for a substantial amount of trait heritability and warrant further fine mapping.\n                  <\/jats:p>","DOI":"10.1161\/strokeaha.109.554121","type":"journal-article","created":{"date-parts":[[2009,6,4]],"date-time":"2009-06-04T22:04:50Z","timestamp":1244153090000},"page":"2307-2312","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":54,"title":["Heritability and Linkage Analysis for Carotid Intima-Media Thickness"],"prefix":"10.1161","volume":"40","author":[{"given":"Ralph L.","family":"Sacco","sequence":"first","affiliation":[{"name":"From the Department of Neurology (R.L.S., H.G., E.S., T.R.) and Human Genetics (R.L.S., S.H.B., S.S., A.B., K.G., L.W.), Miller School of Medicine, University of Miami, Fla; and the Department and Graduate Program of Medical Genetics (S.-H.H.J.), Kaohsiung Medical University, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan H.","family":"Blanton","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.L.S., H.G., E.S., T.R.) and Human Genetics (R.L.S., S.H.B., S.S., A.B., K.G., L.W.), Miller School of Medicine, University of Miami, Fla; and the Department and Graduate Program of Medical Genetics (S.-H.H.J.), Kaohsiung Medical University, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Slifer","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.L.S., H.G., E.S., T.R.) and Human Genetics (R.L.S., S.H.B., S.S., A.B., K.G., L.W.), Miller School of Medicine, University of Miami, Fla; and the Department and Graduate Program of Medical Genetics (S.-H.H.J.), Kaohsiung Medical University, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Beecham","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.L.S., H.G., E.S., T.R.) and Human Genetics (R.L.S., S.H.B., S.S., A.B., K.G., L.W.), Miller School of Medicine, University of Miami, Fla; and the Department and Graduate Program of Medical Genetics (S.-H.H.J.), Kaohsiung Medical University, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaleelah","family":"Glover","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.L.S., H.G., E.S., T.R.) and Human Genetics (R.L.S., S.H.B., S.S., A.B., K.G., L.W.), Miller School of Medicine, University of Miami, Fla; and the Department and Graduate Program of Medical Genetics (S.-H.H.J.), Kaohsiung Medical University, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Gardener","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.L.S., H.G., E.S., T.R.) and Human Genetics (R.L.S., S.H.B., S.S., A.B., K.G., L.W.), Miller School of Medicine, University of Miami, Fla; and the Department and Graduate Program of Medical Genetics (S.-H.H.J.), Kaohsiung Medical University, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyong","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.L.S., H.G., E.S., T.R.) and Human Genetics (R.L.S., S.H.B., S.S., A.B., K.G., L.W.), Miller School of Medicine, University of Miami, Fla; and the Department and Graduate Program of Medical Genetics (S.-H.H.J.), Kaohsiung Medical University, Taiwan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edison","family":"Sabala","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (R.L.S., H.G., E.S., T.R.) and Human Genetics (R.L.S., S.H.B., S.S., A.B., K.G., L.W.), Miller School of Medicine, University of Miami, Fla; 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