{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:01:24Z","timestamp":1791295284855,"version":"4.1.0"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            To investigate the association between thyroid autoantibodies and moyamoya disease (MMD) in patients with an apparent euthyroid state.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            We prospectively studied angiographically diagnosed patients with MMD. We compared demographic profiles, thyroid function test, and thyroid autoantibody status between MMD and control groups.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            A total of 63 patients with MMD, 71 patients with non-MMD stroke, and 200 healthy control subjects were included. The prevalence of elevated thyroid autoantibodies was higher in the MMD group than in other groups (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.01 for MMD versus non-MMD;\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001 for MMD versus control subjects). After adjusting for covariates, the elevated thyroid autoantibodies (OR, 4.871; 95% CI, 1.588 to 15.277) and smoking habits (OR, 0.206 for current smoker; 95% CI, 0.054 to 0.786) were independently associated with MMD versus non-MMD stroke.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Elevated thyroid autoantibodies were frequently observed in patients with MMD. The results of the present study suggest that immune aberrancies associated with or underlying thyroid autoimmunity are also playing a role in developing MMD.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.109.562264","type":"journal-article","created":{"date-parts":[[2009,11,20]],"date-time":"2009-11-20T03:24:41Z","timestamp":1258687481000},"page":"173-176","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":102,"title":["Association of Thyroid Autoantibodies With Moyamoya-Type Cerebrovascular Disease"],"prefix":"10.1161","volume":"41","author":[{"given":"Suk Jae","family":"Kim","sequence":"first","affiliation":[{"name":"From the Department of Neurology (S.J.K., K.G.H., O.Y.B., G.-M.K., C.-S.C., K.H.L.), the Center for Health Promotion (H.Y.S.), and the Departments of Radiology (K.H.K., P.J.) and Neurosurgery (J.S.K., S.-C.H.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; and the Department of Neurology (K.G.H.), Rodem Hospital, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Gi","family":"Heo","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (S.J.K., K.G.H., O.Y.B., G.-M.K., C.-S.C., K.H.L.), the Center for Health Promotion (H.Y.S.), and the Departments of Radiology (K.H.K., P.J.) and Neurosurgery (J.S.K., S.-C.H.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; and the Department of Neurology (K.G.H.), Rodem Hospital, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Young","family":"Shin","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (S.J.K., K.G.H., O.Y.B., G.-M.K., C.-S.C., K.H.L.), the Center for Health Promotion (H.Y.S.), and the Departments of Radiology (K.H.K., P.J.) and Neurosurgery (J.S.K., S.-C.H.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; and the Department of Neurology (K.G.H.), Rodem Hospital, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oh Young","family":"Bang","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (S.J.K., K.G.H., O.Y.B., G.-M.K., C.-S.C., K.H.L.), the Center for Health Promotion (H.Y.S.), and the Departments of Radiology (K.H.K., P.J.) and Neurosurgery (J.S.K., S.-C.H.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; and the Department of Neurology (K.G.H.), Rodem Hospital, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyeong-Moon","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (S.J.K., K.G.H., O.Y.B., G.-M.K., C.-S.C., K.H.L.), the Center for Health Promotion (H.Y.S.), and the Departments of Radiology (K.H.K., P.J.) and Neurosurgery (J.S.K., S.-C.H.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; and the Department of Neurology (K.G.H.), Rodem Hospital, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Sang","family":"Chung","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (S.J.K., K.G.H., O.Y.B., G.-M.K., C.-S.C., K.H.L.), the Center for Health Promotion (H.Y.S.), and the Departments of Radiology (K.H.K., P.J.) and Neurosurgery (J.S.K., S.-C.H.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; and the Department of Neurology (K.G.H.), Rodem Hospital, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keon Ha","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (S.J.K., K.G.H., O.Y.B., G.-M.K., C.-S.C., K.H.L.), the Center for Health Promotion (H.Y.S.), and the Departments of Radiology (K.H.K., P.J.) and Neurosurgery (J.S.K., S.-C.H.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; and the Department of Neurology (K.G.H.), Rodem Hospital, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pyoung","family":"Jeon","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (S.J.K., K.G.H., O.Y.B., G.-M.K., C.-S.C., K.H.L.), the Center for Health Promotion (H.Y.S.), and the Departments of Radiology (K.H.K., P.J.) and Neurosurgery (J.S.K., S.-C.H.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; and the Department of Neurology (K.G.H.), Rodem Hospital, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (S.J.K., K.G.H., O.Y.B., G.-M.K., C.-S.C., K.H.L.), the Center for Health Promotion (H.Y.S.), and the Departments of Radiology (K.H.K., P.J.) and Neurosurgery (J.S.K., S.-C.H.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; and the Department of Neurology (K.G.H.), Rodem Hospital, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Chyul","family":"Hong","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (S.J.K., K.G.H., O.Y.B., G.-M.K., C.-S.C., K.H.L.), the Center for Health Promotion (H.Y.S.), and the Departments of Radiology (K.H.K., P.J.) and Neurosurgery (J.S.K., S.-C.H.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; and the Department of Neurology (K.G.H.), Rodem Hospital, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (S.J.K., K.G.H., O.Y.B., G.-M.K., C.-S.C., K.H.L.), the Center for Health Promotion (H.Y.S.), and the Departments of Radiology (K.H.K., P.J.) and Neurosurgery (J.S.K., S.-C.H.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; and the Department of Neurology (K.G.H.), Rodem Hospital, Seoul, South Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.45.1543"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1997.7.625"},{"key":"e_1_3_2_3_2","first-page":"1541","volume":"25","year":"2004","unstructured":"Utku U, Asil T, Celik Y, Tucer D. Reversible MR angiographic findings in a patient with autoimmune graves disease. AJNR Am J Neuroradiol. 2004; 25: 1541\u20131543.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_2_4_2","unstructured":"Suzuki J Kodama M Fujisawa S. A Study About the Cause of Moyamoya Disease. The 1980 Annual Report of the Research Committee on the Idiopathic Occlusive Disease of Circle of Willis. Tokyo: Japanese Ministry of Health and Welfare; 1981: 21\u201334."},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1071474"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP.9.4.290"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000021409.16314.16"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.29.7.1347"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000221787.70503.ca"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.513408"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.490714"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70240-0"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.109.562264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:07:18Z","timestamp":1715609238000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.109.562264"}},"subtitle":["A Prospective Study"],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["10.1161\/STROKEAHA.109.562264"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.109.562264","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"2009-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-08-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-11-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}