{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T22:14:33Z","timestamp":1766441673777},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Embolic protection devices and improved stent technology have advanced the endovascular treatment of carotid artery disease. A combined analysis was performed of the MAVErIC (\n            <jats:italic>M<\/jats:italic>\n            edtronic\n            <jats:italic>AVE<\/jats:italic>\n            Self-expanding Ca\n            <jats:italic>R<\/jats:italic>\n            otid Stent System with distal protection) I and II trials to evaluate the safety and feasibility of this system among patients at high risk for surgical endarterectomy.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            Four hundred ninety-eight patients were enrolled in the MAVErIC I (99 patients) and MAVErIC II (399 patients) studies from June 2001 to October 2004. The results were pooled for statistical analysis of a common primary end point, the 365-day rate of major adverse events. Clinical follow-up took place at 30 days, 6 months, and 365 days postprocedure.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            The 365-day major adverse event rate, defined as death, stroke, or myocardial infarction within 30 days, and death, ipsilateral stroke, or myocardial infarction from days 31 to 365 was 12.5%. The incidence of neurological death through 365 days was 1.1%. The 30-day major adverse event rate was 5.4%. Subgroup analyses showed no notable differences in the 365-day major adverse event rate for symptomatic patients compared with asymptomatic patients.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion\u2014<\/jats:italic>\n            <\/jats:bold>\n            Treatment of carotid artery disease with carotid artery stenting with a self-expanding stent and distal embolic protection results in a low 30-day adverse event rate, including the occurrence of stroke in patients at high risk for carotid endarterectomy.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.109.564161","type":"journal-article","created":{"date-parts":[[2009,12,25]],"date-time":"2009-12-25T02:51:27Z","timestamp":1261709487000},"update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["Evaluation of the Medtronic Exponent Self-Expanding Carotid Stent System With the Medtronic Guardwire Temporary Occlusion and Aspiration System in the Treatment of Carotid Stenosis"],"prefix":"10.1161","volume":"41","author":[{"given":"Randall T.","family":"Higashida","sequence":"first","affiliation":[{"name":"From the Department of Radiology and Neurosurgery (R.T.H.), University of California at San Francisco Medical Center, San Francisco, Calif; Beth Israel Deaconess Medical Center (J.J.P., P.Z.), Boston, Mass; and Harvard Cardiac Research Institute (P.A.), Boston, Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey J.","family":"Popma","sequence":"additional","affiliation":[{"name":"From the Department of Radiology and Neurosurgery (R.T.H.), University of California at San Francisco Medical Center, San Francisco, Calif; Beth Israel Deaconess Medical Center (J.J.P., P.Z.), Boston, Mass; and Harvard Cardiac Research Institute (P.A.), Boston, Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Apruzzese","sequence":"additional","affiliation":[{"name":"From the Department of Radiology and Neurosurgery (R.T.H.), University of California at San Francisco Medical Center, San Francisco, Calif; Beth Israel Deaconess Medical Center (J.J.P., P.Z.), Boston, Mass; and Harvard Cardiac Research Institute (P.A.), Boston, Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Zimetbaum","sequence":"additional","affiliation":[{"name":"From the Department of Radiology and Neurosurgery (R.T.H.), University of California at San Francisco Medical Center, San Francisco, Calif; Beth Israel Deaconess Medical Center (J.J.P., P.Z.), Boston, Mass; and Harvard Cardiac Research Institute (P.A.), Boston, Mass."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1583\/1074-6218(1996)003<0004:CER>2.0.CO;2"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520420037035"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)09292-1"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811123392002"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1583\/1074-6218(1996)003<0042:SITCAI>2.0.CO;2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04893-5"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040127"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.03.044"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.99.2.0264"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1522-726X(200011)51:3<339::AID-CCD24>3.0.CO;2-T"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.01.035"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.045"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.10645"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000058160.53040.5f"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.29.11.2367"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/152660280301000601"},{"key":"e_1_3_3_17_2","first-page":"759","volume":"27","year":"2006","unstructured":"Hill MD, Morrish W, Soulez G, Nevelsteen A, Maleux G, Rogers C, Hauptmann KE, Bonafe A, Beyar R, Gruberg L, Schofer J. 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