{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T09:37:52Z","timestamp":1725615472283},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            An ethnic extraintracranial difference in atherosclerosis has been well reported, whereas the potential mechanism remains unclear. We aimed to investigate neurovascular coupling in healthy whites and Asians.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods \u2014<\/jats:italic>\n            <\/jats:bold>\n            Twenty volunteers of each ethnicity were recruited to perform a functional transcranial Doppler examination with standardized checkerboard patterns as visual stimulation (3\u00d74, 6\u00d78, and 12\u00d716 checks subtending a visual field section of 18\u00b0\u00d724\u00b0, flicker rate 1 Hz). Hemodynamic responses in both posterior cerebral arteries were evaluated with a control system approach.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            The rate time, that is, the initial speed of flow velocity adaptation, was significantly lower in Asians leading to an approximately 2-second delayed hemodynamic adaptation. The other hemodynamic parameters and the dependency of hemodynamic responses in regard to the complexity degree of the stimulus were similar between groups.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion\u2014<\/jats:italic>\n            <\/jats:bold>\n            The constellation suggests a greater initial mismatch between functionally increased metabolic demand of neurons and adjusted cerebral blood flow in Asians.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.109.566752","type":"journal-article","created":{"date-parts":[[2009,12,25]],"date-time":"2009-12-25T02:51:27Z","timestamp":1261709487000},"page":"383-384","update-policy":"http:\/\/dx.doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Ethnic Influences on Neurovascular Coupling"],"prefix":"10.1161","volume":"41","author":[{"given":"Qing","family":"Hao","sequence":"first","affiliation":[{"name":"From the Department of Medicine and Therapeutics (Q.H., K.S.W., W.H. Lin, W.H. Leung), The Chinese University of Hong Kong, Hong Kong, China; and the Department of Neurology and Internal Medicine (M.K., B.R.), Justus-Liebig University-Giessen, Giessen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence K.S.","family":"Wong","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Therapeutics (Q.H., K.S.W., W.H. Lin, W.H. Leung), The Chinese University of Hong Kong, Hong Kong, China; and the Department of Neurology and Internal Medicine (M.K., B.R.), Justus-Liebig University-Giessen, Giessen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Hua","family":"Lin","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Therapeutics (Q.H., K.S.W., W.H. Lin, W.H. Leung), The Chinese University of Hong Kong, Hong Kong, China; and the Department of Neurology and Internal Medicine (M.K., B.R.), Justus-Liebig University-Giessen, Giessen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas W.H.","family":"Leung","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Therapeutics (Q.H., K.S.W., W.H. Lin, W.H. Leung), The Chinese University of Hong Kong, Hong Kong, China; and the Department of Neurology and Internal Medicine (M.K., B.R.), Justus-Liebig University-Giessen, Giessen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Kaps","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Therapeutics (Q.H., K.S.W., W.H. Lin, W.H. Leung), The Chinese University of Hong Kong, Hong Kong, China; and the Department of Neurology and Internal Medicine (M.K., B.R.), Justus-Liebig University-Giessen, Giessen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Rosengarten","sequence":"additional","affiliation":[{"name":"From the Department of Medicine and Therapeutics (Q.H., K.S.W., W.H. Lin, W.H. Leung), The Chinese University of Hong Kong, Hong Kong, China; and the Department of Neurology and Internal Medicine (M.K., B.R.), Justus-Liebig University-Giessen, Giessen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.04.020"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200404000-00003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1387"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(01)00355-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2003.03090.x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1314"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.4.490"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600377"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.109.566752","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T13:57:21Z","timestamp":1715608641000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.109.566752"}},"subtitle":["A Pilot Study in Whites and Asians"],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1161\/STROKEAHA.109.566752"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.109.566752","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2]]},"assertion":[{"value":"2009-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-09-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-12-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}