{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:28:09Z","timestamp":1777429689328,"version":"3.51.4"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            The Alberta Stroke Program Early CT Score (ASPECTS), a 10-point scale, is a clinical tool for assessment of early ischemic changes after stroke based on the location and extent of a visible stroke lesion. It has been extended for use with MR diffusion-weighted imaging. The purpose of this work was to automate a MR topographical score (MR-TS) using a digital atlas to develop an objective tool for large-scale analyses and possibly reduce interrater variability and slice orientation differences.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            We assessed 30 patients with acute ischemic stroke with a diffusion lesion who provided informed consent. Patients were imaged by CT and MRI within 24 hours of symptom onset. An MR-TS digital atlas was generated using the ASPECTS scoring sheet and anatomic MR data sets. Automated MR topographical scores (auto-MR-TS) were obtained based on the overlap of lesions on apparent diffusion coefficient maps with MR-TS atlas regions. Auto-MR-TS scores were then compared with scores derived manually (man-MR-TS) and with conventional CT ASPECTS scores.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Of the 30 patients, 29 were assessed with auto-MR-TS. Auto-MR-TS was significantly lower than CT ASPECTS (\n            <jats:italic>P<\/jats:italic>\n            &lt;0.001), but with a median difference of only 1 point. There was no significant difference between the auto-MR-TS and the man-MR-TS with a median difference of 0 points; 86% of patient scores differed by \u22641 point.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusion\u2014<\/jats:italic>\n            <\/jats:bold>\n            Auto-MR-TS provides a measure of stroke severity in an automated fashion and facilitates more objective, sensitive, and potentially more complex ASPECTS-based scoring.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.109.567289","type":"journal-article","created":{"date-parts":[[2010,1,22]],"date-time":"2010-01-22T03:09:57Z","timestamp":1264129797000},"page":"455-460","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Atlas-Based Topographical Scoring for Magnetic Resonance Imaging of Acute Stroke"],"prefix":"10.1161","volume":"41","author":[{"given":"Robert K.","family":"Kosior","sequence":"first","affiliation":[{"name":"From Biomedical Engineering (R.K.K., R.F.), Electrical and Computer Engineering (J.C.K., R.F.), Radiology (M.L.L., R.F.), and Clinical Neurosciences (N.S., A.D., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute (R.K.K., J.C.K., A.D., R.F.), University of Calgary, Calgary, Alberta, Canada; and Seaman Family MR Research Centre (R.K.K., M.L.L., N.S., J.C.K., A.D., R.F.), and Calgary Stroke Program (N.S., A.D.), Foothills Medical Centre, Alberta Health Services, Calgary,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Louis","family":"Lauzon","sequence":"additional","affiliation":[{"name":"From Biomedical Engineering (R.K.K., R.F.), Electrical and Computer Engineering (J.C.K., R.F.), Radiology (M.L.L., R.F.), and Clinical Neurosciences (N.S., A.D., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute (R.K.K., J.C.K., A.D., R.F.), University of Calgary, Calgary, Alberta, Canada; and Seaman Family MR Research Centre (R.K.K., M.L.L., N.S., J.C.K., A.D., R.F.), and Calgary Stroke Program (N.S., A.D.), Foothills Medical Centre, Alberta Health Services, Calgary,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolai","family":"Steffenhagen","sequence":"additional","affiliation":[{"name":"From Biomedical Engineering (R.K.K., R.F.), Electrical and Computer Engineering (J.C.K., R.F.), Radiology (M.L.L., R.F.), and Clinical Neurosciences (N.S., A.D., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute (R.K.K., J.C.K., A.D., R.F.), University of Calgary, Calgary, Alberta, Canada; and Seaman Family MR Research Centre (R.K.K., M.L.L., N.S., J.C.K., A.D., R.F.), and Calgary Stroke Program (N.S., A.D.), Foothills Medical Centre, Alberta Health Services, Calgary,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayme C.","family":"Kosior","sequence":"additional","affiliation":[{"name":"From Biomedical Engineering (R.K.K., R.F.), Electrical and Computer Engineering (J.C.K., R.F.), Radiology (M.L.L., R.F.), and Clinical Neurosciences (N.S., A.D., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute (R.K.K., J.C.K., A.D., R.F.), University of Calgary, Calgary, Alberta, Canada; and Seaman Family MR Research Centre (R.K.K., M.L.L., N.S., J.C.K., A.D., R.F.), and Calgary Stroke Program (N.S., A.D.), Foothills Medical Centre, Alberta Health Services, Calgary,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Demchuk","sequence":"additional","affiliation":[{"name":"From Biomedical Engineering (R.K.K., R.F.), Electrical and Computer Engineering (J.C.K., R.F.), Radiology (M.L.L., R.F.), and Clinical Neurosciences (N.S., A.D., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute (R.K.K., J.C.K., A.D., R.F.), University of Calgary, Calgary, Alberta, Canada; and Seaman Family MR Research Centre (R.K.K., M.L.L., N.S., J.C.K., A.D., R.F.), and Calgary Stroke Program (N.S., A.D.), Foothills Medical Centre, Alberta Health Services, Calgary,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Frayne","sequence":"additional","affiliation":[{"name":"From Biomedical Engineering (R.K.K., R.F.), Electrical and Computer Engineering (J.C.K., R.F.), Radiology (M.L.L., R.F.), and Clinical Neurosciences (N.S., A.D., R.F.), University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute (R.K.K., J.C.K., A.D., R.F.), University of Calgary, Calgary, Alberta, Canada; and Seaman Family MR Research Centre (R.K.K., M.L.L., N.S., J.C.K., A.D., R.F.), and Calgary Stroke Program (N.S., A.D.), Foothills Medical Centre, Alberta Health Services, Calgary,..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/00044067-200510000-00002"},{"key":"e_1_3_2_2_2","unstructured":"National Institute of Neurological Diseases and Stroke. 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