{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:32:03Z","timestamp":1777429923266,"version":"3.51.4"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Spontaneous vertebral artery dissection (sVADs) mainly cause cerebral ischemia, with or without associated local symptoms and signs (headache, neck pain, or cervical radiculopathy), or with local symptoms and signs only.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            We compared the presenting characteristics of consecutive patients with single sVADs and ischemic events and those with local symptoms and signs only.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Of the 186 patients with first-ever unilateral sVAD, 165 (89%) presented with cerebral ischemia, and 21 (11%) presented with local symptoms and signs only. Patients with sVAD and ischemia were more often male (63% vs 29%;\n            <jats:italic>P<\/jats:italic>\n            =0.002), older (mean\u00b1SD age, 43.6\u00b19.9 vs 38.6\u00b19.0 years;\n            <jats:italic>P<\/jats:italic>\n            =0.027), and smokers (14% vs 3%;\n            <jats:italic>P<\/jats:italic>\n            =0.010), but less often, they had a history of migraine without aura (17% vs 38%;\n            <jats:italic>P<\/jats:italic>\n            =0.025) than did patients without ischemia. The multivariate analysis confirmed independent associations between male sex (\n            <jats:italic>P<\/jats:italic>\n            =0.024), increasing age (0.027), and smoking (\n            <jats:italic>P<\/jats:italic>\n            =0.012) and sVADs causing cerebral ischemia.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            These results suggest that men, older patients, and smokers with sVADs may be at increased risk for ischemic events.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.109.570655","type":"journal-article","created":{"date-parts":[[2010,2,26]],"date-time":"2010-02-26T03:23:47Z","timestamp":1267154627000},"page":"802-804","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Differences in Demographic Characteristics and Risk Factors in Patients With Spontaneous Vertebral Artery Dissections With and Without Ischemic Events"],"prefix":"10.1161","volume":"41","author":[{"given":"Marcel","family":"Arnold","sequence":"first","affiliation":[{"name":"From the Department of Neurology (M.A., C.S., M.-G.B.), Ho\u0302pital Lariboisie\u0300re, Assistance Publique-Ho\u0302pitaux de Paris, Paris Diderot University, Paris, France; Department of Neurology (M.A., R.K., A.G., U.F., H.P.M.), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Neurology (H.S., D.G., R.W.B.), University Hospital Zurich, Zurich, Switzerland; and Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, Bern University Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebekka","family":"Kurmann","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., C.S., M.-G.B.), Ho\u0302pital Lariboisie\u0300re, Assistance Publique-Ho\u0302pitaux de Paris, Paris Diderot University, Paris, France; Department of Neurology (M.A., R.K., A.G., U.F., H.P.M.), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Neurology (H.S., D.G., R.W.B.), University Hospital Zurich, Zurich, Switzerland; and Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, Bern University Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aekaterini","family":"Galimanis","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., C.S., M.-G.B.), Ho\u0302pital Lariboisie\u0300re, Assistance Publique-Ho\u0302pitaux de Paris, Paris Diderot University, Paris, France; Department of Neurology (M.A., R.K., A.G., U.F., H.P.M.), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Neurology (H.S., D.G., R.W.B.), University Hospital Zurich, Zurich, Switzerland; and Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, Bern University Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Sarikaya","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., C.S., M.-G.B.), Ho\u0302pital Lariboisie\u0300re, Assistance Publique-Ho\u0302pitaux de Paris, Paris Diderot University, Paris, France; Department of Neurology (M.A., R.K., A.G., U.F., H.P.M.), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Neurology (H.S., D.G., R.W.B.), University Hospital Zurich, Zurich, Switzerland; and Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, Bern University Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Stapf","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., C.S., M.-G.B.), Ho\u0302pital Lariboisie\u0300re, Assistance Publique-Ho\u0302pitaux de Paris, Paris Diderot University, Paris, France; Department of Neurology (M.A., R.K., A.G., U.F., H.P.M.), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Neurology (H.S., D.G., R.W.B.), University Hospital Zurich, Zurich, Switzerland; and Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, Bern University Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Gralla","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., C.S., M.-G.B.), Ho\u0302pital Lariboisie\u0300re, Assistance Publique-Ho\u0302pitaux de Paris, Paris Diderot University, Paris, France; Department of Neurology (M.A., R.K., A.G., U.F., H.P.M.), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Neurology (H.S., D.G., R.W.B.), University Hospital Zurich, Zurich, Switzerland; and Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, Bern University Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Georgiadis","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., C.S., M.-G.B.), Ho\u0302pital Lariboisie\u0300re, Assistance Publique-Ho\u0302pitaux de Paris, Paris Diderot University, Paris, France; Department of Neurology (M.A., R.K., A.G., U.F., H.P.M.), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Neurology (H.S., D.G., R.W.B.), University Hospital Zurich, Zurich, Switzerland; and Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, Bern University Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urs","family":"Fischer","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., C.S., M.-G.B.), Ho\u0302pital Lariboisie\u0300re, Assistance Publique-Ho\u0302pitaux de Paris, Paris Diderot University, Paris, France; Department of Neurology (M.A., R.K., A.G., U.F., H.P.M.), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Neurology (H.S., D.G., R.W.B.), University Hospital Zurich, Zurich, Switzerland; and Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, Bern University Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich P.","family":"Mattle","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., C.S., M.-G.B.), Ho\u0302pital Lariboisie\u0300re, Assistance Publique-Ho\u0302pitaux de Paris, Paris Diderot University, Paris, France; Department of Neurology (M.A., R.K., A.G., U.F., H.P.M.), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Neurology (H.S., D.G., R.W.B.), University Hospital Zurich, Zurich, Switzerland; and Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, Bern University Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Germaine","family":"Bousser","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., C.S., M.-G.B.), Ho\u0302pital Lariboisie\u0300re, Assistance Publique-Ho\u0302pitaux de Paris, Paris Diderot University, Paris, France; Department of Neurology (M.A., R.K., A.G., U.F., H.P.M.), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Neurology (H.S., D.G., R.W.B.), University Hospital Zurich, Zurich, Switzerland; and Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, Bern University Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf W.","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., C.S., M.-G.B.), Ho\u0302pital Lariboisie\u0300re, Assistance Publique-Ho\u0302pitaux de Paris, Paris Diderot University, Paris, France; Department of Neurology (M.A., R.K., A.G., U.F., H.P.M.), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Neurology (H.S., D.G., R.W.B.), University Hospital Zurich, Zurich, Switzerland; and Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, Bern University Hospital,..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000240493.88473.39"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.063107"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.5.827"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000237341.30854.6a"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.094359"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.108.540781"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38331.655347.8F"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.1.72"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00266-7"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000108395.12766.25"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-0620(03)00087-2"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(96)00017-5"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.99.11.1411"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199601183340303"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.104.492215"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.109.570655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T08:10:28Z","timestamp":1738829428000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.109.570655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["10.1161\/STROKEAHA.109.570655"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.109.570655","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"2009-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-12-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-02-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}