{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:00:37Z","timestamp":1772164837435,"version":"3.50.1"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>Background and Purpose\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    In humans and rodents, cortical stroke can lead to cortex atrophy in long-term survivors. In the rodent, fetal brain neural precursors or stem cell\u2013derived neurons grafted in the stroke-lesioned brain integrate successfully and reduce infarct in the short term. We have examined the fate, in the long term, of mouse embryonic stem cell\u2013derived neural precursors grafted after permanent middle cerebral artery occlusion in mice.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Green fluorescent protein-labeled neural precursors were grafted in the striatum of control and lesioned mice and their fate examined 9 months later.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Results\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    In control mice, the neuronal progeny of mouse embryonic stem cells innervated distant brain structures, in a way remarkably similar between animals, displayed a laterality preference and remained polysialated neural cell adhesion molecule-immunoreactive. In lesioned mice, grafted cells were expelled out of the brain.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusions\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Stroke-related brain atrophy and reshaping were not prevented by cell grafting and, eventually, led to the expulsion of the graft.\n                  <\/jats:p>","DOI":"10.1161\/strokeaha.110.578427","type":"journal-article","created":{"date-parts":[[2010,6,25]],"date-time":"2010-06-25T00:14:20Z","timestamp":1277424860000},"page":"1807-1814","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Stem Cell\u2013Derived Neurons Grafted in the Striatum Are Expelled Out of the Brain After Chronic Cortical Stroke"],"prefix":"10.1161","volume":"41","author":[{"given":"Michel","family":"Dubois-Dauphin","sequence":"first","affiliation":[{"name":"From the Department of Pathology and Immunology, CMU-University of Geneva, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ste\u0301phanie","family":"Julien","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Immunology, CMU-University of Geneva, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-005-1398-0"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2004.tb00249.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/028418519003100502"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.22.5.2028491"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000039406.64644.cb"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200110080-00032"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.21.10.2219214"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)91273-U"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.503565"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.041699"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90690-D"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.7.1052"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000239667.15532.c1"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90744-V"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-009-0516-1"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl261"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.219"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2001.7750"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.07.026"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm053"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.06.005"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903230403"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.21.090704.151234"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7170-3"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.07.005"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2006-7-3-211"},{"key":"e_1_3_2_27_2","first-page":"81","volume":"26","year":"2008","unstructured":"Zhang Y, Yeh J, Richardson PM, Bo X. Cell adhesion molecules of the immunoglobulin superfamily in axonal regeneration and neural repair. Restor Neurol Neurosci. 2008; 26: 81\u201396.","journal-title":"Restor Neurol Neurosci"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0226"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00984.x"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00697.x"},{"key":"e_1_3_2_31_2","unstructured":"Franklin KBJ Paxinos G. The Mouse Brain in Stereotaxic Coordinates. San Diego: Academic Press; 1997."},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1991.tb00814.x"},{"key":"e_1_3_2_33_2","unstructured":"Paxinos G. The Rat Nervous System. Sydney Australia and Montreal Canada: Academic Press; 1995."},{"key":"e_1_3_2_34_2","unstructured":"Paxinos G. The Rat Nervous System. Amsterdam The Netherlands and Boston: Elsevier Academic Press; 2004."},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.11.014"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.05.014"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10387"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-0102(93)90111-3"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0218"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.110.578427","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T09:59:07Z","timestamp":1715594347000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.110.578427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1161\/STROKEAHA.110.578427"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.110.578427","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.4942968.4875068","asserted-by":"object"}]},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8]]},"assertion":[{"value":"2010-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-04-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}