{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:35:28Z","timestamp":1791300928520,"version":"4.1.0"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p>\n                    <jats:bold>\n                      <jats:italic>Background and Purpose\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    The Mini-Mental State Examination (MMSE) is insensitive to mild cognitive impairment and executive function. The more recently developed Montreal Cognitive Assessment (MoCA), an alternative, brief 30-point global cognitive screen, might pick up more cognitive abnormalities in patients with cerebrovascular disease.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Methods\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    In a population-based study (Oxford Vascular Study) of transient ischemic attack and stroke, the MMSE and MoCA were administered to consecutive patients at 6-month or 5-year follow-up. Accepted cutoffs of MMSE &lt;27 and MoCA &lt;26 were taken to indicate cognitive impairment.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Results\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    Of 493 patients, 413 (84%) were testable. Untestable patients were older (75.5 versus 69.9 years,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001) and often had dysphasia (24%) or dementia (15%). Although MMSE and MoCA scores were highly correlated (\n                    <jats:italic>r<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    =0.80,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001), MMSE scores were skewed toward higher values, whereas MoCA scores were normally distributed: median and interquartile range 28 (26 to 29) and 23 (20 to 26), respectively. Two hundred ninety-one of 413 (70%) patients had MoCA &lt;26 of whom 162 had MMSE \u226527, whereas only 5 patients had MoCA \u226526 and MMSE &lt;27 (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.0001). In patients with MMSE \u226527, MoCA &lt;26 was associated with higher Rankin scores (\n                    <jats:italic>P<\/jats:italic>\n                    =0.0003) and deficits in delayed recall, abstraction, visuospatial\/executive function, and sustained attention.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>\n                      <jats:italic>Conclusion\u2014<\/jats:italic>\n                    <\/jats:bold>\n                    The MoCA picked up substantially more cognitive abnormalities after transient ischemic attack and stroke than the MMSE, demonstrating deficits in executive function, attention, and delayed recall.\n                  <\/jats:p>","DOI":"10.1161\/strokeaha.110.579888","type":"journal-article","created":{"date-parts":[[2010,4,8]],"date-time":"2010-04-08T22:55:11Z","timestamp":1270767311000},"page":"1290-1293","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":414,"title":["Underestimation of Cognitive Impairment by Mini-Mental State Examination Versus the Montreal Cognitive Assessment in Patients With Transient Ischemic Attack and Stroke"],"prefix":"10.1161","volume":"41","author":[{"given":"Sarah T.","family":"Pendlebury","sequence":"first","affiliation":[{"name":"From the Stroke Prevention Research Unit (S.T.P., F.C.C., S.J.V.W., Z.M., P.M.R.), University Department of Clinical Neurology, John Radcliffe Hospital and the University of Oxford, Oxford, UK; and the National Institute of Health Research Biomedical Research Centre (S.T.P.), John Radcliffe Hospital, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona C.","family":"Cuthbertson","sequence":"additional","affiliation":[{"name":"From the Stroke Prevention Research Unit (S.T.P., F.C.C., S.J.V.W., Z.M., P.M.R.), University Department of Clinical Neurology, John Radcliffe Hospital and the University of Oxford, Oxford, UK; and the National Institute of Health Research Biomedical Research Centre (S.T.P.), John Radcliffe Hospital, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.V.","family":"Welch","sequence":"additional","affiliation":[{"name":"From the Stroke Prevention Research Unit (S.T.P., F.C.C., S.J.V.W., Z.M., P.M.R.), University Department of Clinical Neurology, John Radcliffe Hospital and the University of Oxford, Oxford, UK; and the National Institute of Health Research Biomedical Research Centre (S.T.P.), John Radcliffe Hospital, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyah","family":"Mehta","sequence":"additional","affiliation":[{"name":"From the Stroke Prevention Research Unit (S.T.P., F.C.C., S.J.V.W., Z.M., P.M.R.), University Department of Clinical Neurology, John Radcliffe Hospital and the University of Oxford, Oxford, UK; and the National Institute of Health Research Biomedical Research Centre (S.T.P.), John Radcliffe Hospital, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Rothwell","sequence":"additional","affiliation":[{"name":"From the Stroke Prevention Research Unit (S.T.P., F.C.C., S.J.V.W., Z.M., P.M.R.), University Department of Clinical Neurology, John Radcliffe Hospital and the University of Oxford, Oxford, UK; and the National Institute of Health Research Biomedical Research Centre (S.T.P.), John Radcliffe Hospital, Oxford, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.102533"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70236-4"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1992.tb01992.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21837"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03500180078038"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.110.579888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:39:38Z","timestamp":1715596778000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.110.579888"}},"subtitle":["A Population-Based Study"],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1161\/STROKEAHA.110.579888"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.110.579888","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"2010-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-02-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-04-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}