{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T04:40:15Z","timestamp":1776314415013,"version":"3.50.1"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Extending the duration of continuous electrocardiography after ischemic stroke detects more new cases of atrial fibrillation, which is an important and treatable cause of stroke, but the cost-effectiveness of this approach is unknown. Therefore, we performed a cost-utility analysis of outpatient cardiac monitoring after ischemic stroke.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            Using a Markov model, we determined the lifetime cost and utility of warfarin therapy in a hypothetical cohort of 70-year-old patients with atrial fibrillation, prior stroke, and no contraindication to warfarin therapy. Meta-analysis was used to determine the yield of outpatient cardiac monitoring.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Outpatient cardiac monitoring would detect 44 new cases of atrial fibrillation for every 1000 patients monitored. This would result in a gain of 34 quality-adjusted life-years at a net cost of $440 000. Therefore, the cost-utility ratio of outpatient cardiac monitoring would be $13 000 per quality-adjusted life-years gained. Outpatient monitoring remained cost-effective throughout a wide range of model inputs in sensitivity analyses, including changes in the cost and yield of monitoring.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            By identifying patients with paroxysmal atrial fibrillation who will benefit from anticoagulation, outpatient cardiac monitoring is cost-effective after ischemic stroke over a wide range of model inputs. The optimal duration and method of monitoring is unknown.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.110.582437","type":"journal-article","created":{"date-parts":[[2010,5,28]],"date-time":"2010-05-28T02:39:41Z","timestamp":1275014381000},"page":"1514-1520","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":74,"title":["Cost-Effectiveness of Outpatient Cardiac Monitoring to Detect Atrial Fibrillation After Ischemic Stroke"],"prefix":"10.1161","volume":"41","author":[{"given":"Hooman","family":"Kamel","sequence":"first","affiliation":[{"name":"From the Department of Neurology (H.K., M.H., D.R.J., S.C.J.), University of California, San Francisco, Calif; and the Department of Medicine (B.F.G.), Washington University School of Medicine, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manu","family":"Hegde","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (H.K., M.H., D.R.J., S.C.J.), University of California, San Francisco, Calif; and the Department of Medicine (B.F.G.), Washington University School of Medicine, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek R.","family":"Johnson","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (H.K., M.H., D.R.J., S.C.J.), University of California, San Francisco, Calif; and the Department of Medicine (B.F.G.), Washington University School of Medicine, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian F.","family":"Gage","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (H.K., M.H., D.R.J., S.C.J.), University of California, San Francisco, Calif; and the Department of Medicine (B.F.G.), Washington University School of Medicine, St Louis, Mo."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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