{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T03:18:57Z","timestamp":1794107937400,"version":"4.8.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Current available therapies for neonatal hypoxia\/ischemia (H\/I) brain injury are rather limited. Here, we investigated the effect of omega-3 polyunsaturated fatty acids on brain damage and long-term neurological function after H\/I in neonates.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            Female rats were treated with or without an omega-3 polyunsaturated fatty acids-enriched diet from the second day of pregnancy until 14 days after parturition. Seven-day-old neonates were subjected to H\/I and euthanized 5 weeks later for evaluation of tissue loss. Neurological impairment was assessed progressively for 5 weeks after H\/I by grid walking, foot fault, and Morris water maze. Activation of microglia and production of inflammatory mediators were examined up to 7 days after H\/I.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Omega-3 polyunsaturated fatty acid supplementation significantly reduced brain damage and improved long-term neurological outcomes up to 5 weeks after neonatal H\/I injury. Omega-3 polyunsaturated fatty acids exerted an anti-inflammatory effect in microglia both in an in vivo model of H\/I and in in vitro microglial cultures subjected to inflammatory stimuli by inhibiting NF-\u03baB activation and subsequent release of inflammatory mediators.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Our results suggest that omega-3 polyunsaturated fatty acids confer potent neuroprotection against neonatal H\/I brain injury through, at least partially, suppressing a microglial-mediated inflammatory response.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.110.586081","type":"journal-article","created":{"date-parts":[[2010,8,13]],"date-time":"2010-08-13T02:51:35Z","timestamp":1281667895000},"page":"2341-2347","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":109,"title":["Omega-3 Polyunsaturated Fatty Acid Supplementation Confers Long-Term Neuroprotection Against Neonatal Hypoxic\u2013Ischemic Brain Injury Through Anti-Inflammatory Actions"],"prefix":"10.1161","volume":"41","author":[{"given":"Wenting","family":"Zhang","sequence":"first","affiliation":[{"name":"From the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (W.Z., W.Y., Y.G., J.C.), Fudan University, Shanghai, China; the Department of Neurology and Center of Cerebrovascular Disease Research (W.Z., X.H., Y.G., J.C.), University of Pittsburgh School of Medicine, Pittsburgh, Pa; and the Geriatric Research, Educational and Clinical Center (X.H., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Hu","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (W.Z., W.Y., Y.G., J.C.), Fudan University, Shanghai, China; the Department of Neurology and Center of Cerebrovascular Disease Research (W.Z., X.H., Y.G., J.C.), University of Pittsburgh School of Medicine, Pittsburgh, Pa; and the Geriatric Research, Educational and Clinical Center (X.H., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (W.Z., W.Y., Y.G., J.C.), Fudan University, Shanghai, China; the Department of Neurology and Center of Cerebrovascular Disease Research (W.Z., X.H., Y.G., J.C.), University of Pittsburgh School of Medicine, Pittsburgh, Pa; and the Geriatric Research, Educational and Clinical Center (X.H., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqin","family":"Gao","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (W.Z., W.Y., Y.G., J.C.), Fudan University, Shanghai, China; the Department of Neurology and Center of Cerebrovascular Disease Research (W.Z., X.H., Y.G., J.C.), University of Pittsburgh School of Medicine, Pittsburgh, Pa; and the Geriatric Research, Educational and Clinical Center (X.H., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[{"name":"From the State Key Laboratory of Medical Neurobiology and Institute of Brain Science (W.Z., W.Y., Y.G., J.C.), Fudan University, Shanghai, China; the Department of Neurology and Center of Cerebrovascular Disease Research (W.Z., X.H., Y.G., J.C.), University of Pittsburgh School of Medicine, Pittsburgh, Pa; and the Geriatric Research, Educational and Clinical Center (X.H., J.C.), Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pa."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.094"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070979"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-14-05910.2002"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600002"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.01.037"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1179\/016164105X25216"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199904010-00008"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06286.x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601280103"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.555979"},{"key":"e_1_3_3_11_2","first-page":"305.e301","volume":"200","year":"2009","unstructured":"Berman DR, Mozurkewich E, Liu Y, Barks J. Docosahexaenoic acid pretreatment confers neuroprotection in a rat model of perinatal cerebral hypoxia\u2013ischemia. Am J Obstet Gynecol. 2009; 200: 305.e301\u2013e306.","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.12.010"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4407-08.2008"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)38861-1"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.11.015"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000155758.79523.44"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800068-JLR200"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00114-003-0470-z"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5857-08.2009"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.4.855"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.110.586081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:40:10Z","timestamp":1715611210000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.110.586081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1161\/STROKEAHA.110.586081"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.110.586081","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"2010-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-06-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-08-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}