{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T22:13:00Z","timestamp":1773526380651,"version":"3.50.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            The prognosis of spontaneous intracerebral hemorrhage (sICH) is poor because of the mass effect arising from the hematoma and the associated peri-hemorrhagic edema, leading to increased intracranial pressure. Because the efficacy of surgical and anti-edematous treatment strategies is limited, we investigated the effects of mild induced hypothermia in patients with large sICH.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            Twelve patients with supratentorial sICH &gt;25 mL were treated by hypothermia of 35\u00b0C for 10 days. Evolution of hematoma volume and perifocal edema was measured by cranial CT. Functional outcome was assessed after 90 days. These patients were compared to patients (n=25; inclusion criteria: sICH volume &gt;25 mL, no acute restriction of medical therapy on admission) from the local hemorrhage data bank (n=312). Side effects of hypothermia were analyzed.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            All patients from both groups needed mechanical ventilation and were treated in a neurocritical care unit. All hypothermic patients (mean age, 60\u00b110 years) survived until day 90, whereas 7 patients died in the control group (mean age, 67\u00b17 years). Absolute hematoma size on admission was 58\u00b129 mL (hypothermia) compared to 57\u00b131 mL (control). In the hypothermia group, edema volume remained stable during 14 days (day 1, 53\u00b143 mL; day 14, 57\u00b145 mL), whereas edema significantly increased in the control group from 40\u00b128 mL (day 1) to 88\u00b147 mL (day 14). ICH continuously dissolved in both groups. Pneumonia rate was 100% in the hypothermia group and 76% in controls (\n            <jats:italic>P<\/jats:italic>\n            =0.08). No significant side effects of hypothermia were observed.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Hypothermia prevented the increase of peri-hemorrhagic edema in patients with large sICH.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.110.587758","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T03:04:53Z","timestamp":1278644693000},"page":"1684-1689","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":151,"title":["Hypothermia Reduces Perihemorrhagic Edema After Intracerebral Hemorrhage"],"prefix":"10.1161","volume":"41","author":[{"given":"Rainer","family":"Kollmar","sequence":"first","affiliation":[{"name":"From Neurology Department (R.K., D.S., P.D.S., S.S., J.B.) and Department of Neuroradiology (A.D.), University of Erlangen, Erlangen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitre","family":"Staykov","sequence":"additional","affiliation":[{"name":"From Neurology Department (R.K., D.S., P.D.S., S.S., J.B.) and Department of Neuroradiology (A.D.), University of Erlangen, Erlangen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnd","family":"Do\u0308rfler","sequence":"additional","affiliation":[{"name":"From Neurology Department (R.K., D.S., P.D.S., S.S., J.B.) and Department of Neuroradiology (A.D.), University of Erlangen, Erlangen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D.","family":"Schellinger","sequence":"additional","affiliation":[{"name":"From Neurology Department (R.K., D.S., P.D.S., S.S., J.B.) and Department of Neuroradiology (A.D.), University of Erlangen, Erlangen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schwab","sequence":"additional","affiliation":[{"name":"From Neurology Department (R.K., D.S., P.D.S., S.S., J.B.) and Department of Neuroradiology (A.D.), University of Erlangen, Erlangen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju\u0308rgen","family":"Bardutzky","sequence":"additional","affiliation":[{"name":"From Neurology Department (R.K., D.S., P.D.S., S.S., J.B.) and Department of Neuroradiology (A.D.), University of Erlangen, Erlangen, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1993.78.2.0188"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.183689"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.24.7.8322400"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.28.1.1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.22.1.1987664"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.30.6.1167"},{"key":"e_1_3_3_7_2","first-page":"463","volume":"76","year":"2000","unstructured":"Fernandes HM, Siddique S, Banister K, Chambers I, Wooldridge T, Gregson B, Mendelow AD. 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Mild therapeutic hypothermia to improve the neurologic outcome after cardiacarrest. N Engl J Med. 2002; 346: 549\u2013556. Erratum in N Engl J Med. 2002; 346: 1756.","journal-title":"Erratum in N Engl J Med"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60837-5"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.08.018"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000217268.81963.78"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2008.01.003"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000094831"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.32.11.2550"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c55ed3"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000035283.34109.ea"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-005-0021-3"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000129840.66938.75"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.32.8.1847"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1765"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.29.12.2461"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.32.12.2833"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.110.587758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T13:58:12Z","timestamp":1715608692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.110.587758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["10.1161\/STROKEAHA.110.587758"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.110.587758","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8]]},"assertion":[{"value":"2010-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-07-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}