{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:23:21Z","timestamp":1792031001664,"version":"4.4.0"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Cerebellar venous infarction or hemorrhage due to isolated venous thrombosis of the posterior fossa is a rare form of intracranial vein thrombosis that can be unsuspected in clinical practice.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            We studied 230 patients with intracranial vein thrombosis, identifying 9 (3.9%: 7 women, mean age 34 years) with neuroimaging or histopathologic evidence of localized posterior fossa vein thrombosis causing parenchymal injury limited exclusively to the cerebellum.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            All patients had an insidious presentation suggesting other diagnoses. Intracranial hypertension (n=6) and cerebellar (n=4) syndromes were the main clinical presentations. Intracranial vein thrombosis was idiopathic in 3 patients; associated with puerperium in 3; and with contraceptives, protein C deficiency, and dehydration in 1 case each. CT was abnormal but not diagnostic in 5 patients, showing a cerebellar hypodensity with fourth ventricle compression and variable hydrocephalus in 5 patients, and cerebellar hemorrhage in 2. Conventional MRI provided diagnosis in 6 cases, showing the causal thrombosis and cerebellar involvement; angiography was practiced in 2 of them, confirming the findings identified by MRI. In the other 3 patients, diagnosis was reached by histopathology. Thromboses were localized at the straight sinus (n=4), lateral sinuses (n=3), and superior petrosal vein (n=2). The acute case fatality rate was 22.2% (n=2), 1 (11.1%) patient was discharged in a vegetative state, 1 (11.1%) was severely disabled, and 5 (55.6%) were moderately disabled.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Isolated venous thrombosis of the posterior fossa is infrequent and implies a challenging diagnosis. Risk factors for intracranial vein thrombosis and atypical cerebellar findings on CT should lead to further MRI assessment.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.110.588202","type":"journal-article","created":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T02:47:49Z","timestamp":1282877269000},"page":"2358-2361","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Isolated Vein Thrombosis of the Posterior Fossa Presenting as Localized Cerebellar Venous Infarctions or Hemorrhages"],"prefix":"10.1161","volume":"41","author":[{"given":"Jose\u0301 L.","family":"Ruiz-Sandoval","sequence":"first","affiliation":[{"name":"From the Department of Neurology and Neurosurgery (J.L.R.-S., J.N.-B., A.O.-G.), Hospital Civil de Guadalajara \u201cFray Antonio Alcalde,\u201d and the Department of Neurosciences, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, Mexico; the Department of Internal Medicine (E.C.), Hospital Civil de Guadalajara \u201cFray Antonio Alcalde,\u201d Universidad de Guadalajara, Guadalajara, Mexico; and the Stroke Clinic (A.A.-G., F.B., C.C.), Instituto Nacional de Neurologi\u0301a y..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"Chiquete","sequence":"additional","affiliation":[{"name":"From the Department of Neurology and Neurosurgery (J.L.R.-S., J.N.-B., A.O.-G.), Hospital Civil de Guadalajara \u201cFray Antonio Alcalde,\u201d and the Department of Neurosciences, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, Mexico; the Department of Internal Medicine (E.C.), Hospital Civil de Guadalajara \u201cFray Antonio Alcalde,\u201d Universidad de Guadalajara, Guadalajara, Mexico; and the Stroke Clinic (A.A.-G., F.B., C.C.), Instituto Nacional de Neurologi\u0301a y..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Navarro-Bonnet","sequence":"additional","affiliation":[{"name":"From the Department of Neurology and Neurosurgery (J.L.R.-S., J.N.-B., A.O.-G.), Hospital Civil de Guadalajara \u201cFray Antonio Alcalde,\u201d and the Department of Neurosciences, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, Mexico; the Department of Internal Medicine (E.C.), Hospital Civil de Guadalajara \u201cFray Antonio Alcalde,\u201d Universidad de Guadalajara, Guadalajara, Mexico; and the Stroke Clinic (A.A.-G., F.B., C.C.), Instituto Nacional de Neurologi\u0301a y..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Ochoa-Guzma\u0301n","sequence":"additional","affiliation":[{"name":"From the Department of Neurology and Neurosurgery (J.L.R.-S., J.N.-B., A.O.-G.), Hospital Civil de Guadalajara \u201cFray Antonio Alcalde,\u201d and the Department of Neurosciences, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, Mexico; the Department of Internal Medicine (E.C.), Hospital Civil de Guadalajara \u201cFray Antonio Alcalde,\u201d Universidad de Guadalajara, Guadalajara, Mexico; and the Stroke Clinic (A.A.-G., F.B., C.C.), Instituto Nacional de Neurologi\u0301a y..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Arauz-Go\u0301ngora","sequence":"additional","affiliation":[{"name":"From the Department of Neurology and Neurosurgery (J.L.R.-S., J.N.-B., A.O.-G.), Hospital Civil de Guadalajara \u201cFray Antonio Alcalde,\u201d and the Department of Neurosciences, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, Mexico; the Department of Internal Medicine (E.C.), Hospital Civil de Guadalajara \u201cFray Antonio Alcalde,\u201d Universidad de Guadalajara, Guadalajara, Mexico; and the Stroke Clinic (A.A.-G., F.B., C.C.), Instituto Nacional de Neurologi\u0301a y..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Barinagarrementeri\u0301a","sequence":"additional","affiliation":[{"name":"From the Department of Neurology and Neurosurgery (J.L.R.-S., J.N.-B., A.O.-G.), Hospital Civil de Guadalajara \u201cFray Antonio Alcalde,\u201d and the Department of Neurosciences, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, Mexico; the Department of Internal Medicine (E.C.), Hospital Civil de Guadalajara \u201cFray Antonio Alcalde,\u201d Universidad de Guadalajara, Guadalajara, Mexico; and the Stroke Clinic (A.A.-G., F.B., C.C.), Instituto Nacional de Neurologi\u0301a y..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Cantu\u0301","sequence":"additional","affiliation":[{"name":"From the Department of Neurology and Neurosurgery (J.L.R.-S., J.N.-B., A.O.-G.), Hospital Civil de Guadalajara \u201cFray Antonio Alcalde,\u201d and the Department of Neurosciences, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, Mexico; the Department of Internal Medicine (E.C.), Hospital Civil de Guadalajara \u201cFray Antonio Alcalde,\u201d Universidad de Guadalajara, Guadalajara, Mexico; and the Stroke Clinic (A.A.-G., F.B., C.C.), Instituto Nacional de Neurologi\u0301a y..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000117571.76197.26"},{"key":"e_1_3_3_2_2","first-page":"209","volume":"144","year":"1988","unstructured":"Rousseaux M, Lesoin F, Barbaste P, Jomin M. Infarctus c\u00e9r\u00e9belleux pseudo-tumoral d\u2019origine veineuse. Rev Neurol (Paris). 1988; 144: 209\u2013211.","journal-title":"Rev Neurol (Paris)"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.5.837"},{"key":"e_1_3_3_4_2","first-page":"51","volume":"17","year":"1989","unstructured":"Ushiwata I, Saiki I, Murakami T, Kanaya H, Konno J, Wada S. Transverse sinus thrombosis accompanied by intracerebellar hemorrhage: a case report. No Shinkei Geka. 1989; 17: 51\u201355.","journal-title":"No Shinkei Geka"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.25.5.8165678"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2001.tb00073.x"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-005-0501-y"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.49.359"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/neurosurgery\/47.3.S69"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.509711"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.110.588202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:39:21Z","timestamp":1715611161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.110.588202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["10.1161\/STROKEAHA.110.588202"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.110.588202","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"2010-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-07-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-08-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}