{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:49:05Z","timestamp":1780105745595,"version":"3.54.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Mitochondria play a critical role in mediating cell death in both the adult and immature brain. The cyclophilin D mitochondrial membrane permeability transition pore is critical in adult ischemia, whereas in neonatal hypoxic\u2013ischemic (HI) brain injury, mitochondrial permeabilization appears to be primarily Bax-dependent. The aim of this study was to evaluate the neuroprotective effect of a cell-penetrating Bax-inhibiting peptide (BIP) on neonatal mouse HI brain injury.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            BIP (5 \u03bcL, 5 mg\/mL) or a BIP-negative control (5 \u03bcL, 5 mg\/mL) was injected intracerebroventricularly immediately before HI in postnatal day 9 mice. Mice were euthanized at different time points after HI for evaluation of brain injury, Bax activation, release of proapoptotic proteins, and caspase activation. The trace fear conditioning and cylinder tests were performed for evaluation of the functional recovery after BIP treatment.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            At 5 days after HI, there was a 41.2% reduction of brain injury in BIP-treated mice compared with BIP-negative control treated animals. Myelin basic protein and neurofilament quantification revealed that BIP reduced white matter injury. BIP treatment conferred improvement in both sensorimotor and memory functions at 7 weeks after HI. BIP protection was associated with a reduction of Bax activation, mitochondrial permeabilization, and downstream caspase activation.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            Bax inhibition provides neuroprotection and functional improvement in a neonatal mouse model of HI.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.110.589051","type":"journal-article","created":{"date-parts":[[2010,7,30]],"date-time":"2010-07-30T03:16:57Z","timestamp":1280459817000},"page":"2050-2055","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":63,"title":["Neuroprotective Effect of Bax-Inhibiting Peptide on Neonatal Brain Injury"],"prefix":"10.1161","volume":"41","author":[{"given":"Xiaoyang","family":"Wang","sequence":"first","affiliation":[{"name":"From the Perinatal Center (X.W., W.H., X.D., Y.C., C.M., E.J., H.H.), Department of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; the Department of Pediatrics (X.W., W.H., X.D., C.Z.), The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China; the Center for Brain Repair and Rehabilitation (C.Z.), Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; the Perinatal Center (Y.C., H.H.), Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[{"name":"From the Perinatal Center (X.W., W.H., X.D., Y.C., C.M., E.J., H.H.), Department of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; the Department of Pediatrics (X.W., W.H., X.D., C.Z.), The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China; the Center for Brain Repair and Rehabilitation (C.Z.), Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; the Perinatal Center (Y.C., H.H.), Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaonan","family":"Du","sequence":"additional","affiliation":[{"name":"From the Perinatal Center (X.W., W.H., X.D., Y.C., C.M., E.J., H.H.), Department of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; the Department of Pediatrics (X.W., W.H., X.D., C.Z.), The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China; the Center for Brain Repair and Rehabilitation (C.Z.), Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; the Perinatal Center (Y.C., H.H.), Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlian","family":"Zhu","sequence":"additional","affiliation":[{"name":"From the Perinatal Center (X.W., W.H., X.D., Y.C., C.M., E.J., H.H.), Department of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; the Department of Pediatrics (X.W., W.H., X.D., C.Z.), The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China; the Center for Brain Repair and Rehabilitation (C.Z.), Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; the Perinatal Center (Y.C., H.H.), Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ylva","family":"Carlsson","sequence":"additional","affiliation":[{"name":"From the Perinatal Center (X.W., W.H., X.D., Y.C., C.M., E.J., H.H.), Department of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; the Department of Pediatrics (X.W., W.H., X.D., C.Z.), The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China; the Center for Brain Repair and Rehabilitation (C.Z.), Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; the Perinatal Center (Y.C., H.H.), Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Mallard","sequence":"additional","affiliation":[{"name":"From the Perinatal Center (X.W., W.H., X.D., Y.C., C.M., E.J., H.H.), Department of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; the Department of Pediatrics (X.W., W.H., X.D., C.Z.), The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China; the Center for Brain Repair and Rehabilitation (C.Z.), Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; the Perinatal Center (Y.C., H.H.), Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Jacotot","sequence":"additional","affiliation":[{"name":"From the Perinatal Center (X.W., W.H., X.D., Y.C., C.M., E.J., H.H.), Department of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; the Department of Pediatrics (X.W., W.H., X.D., C.Z.), The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China; the Center for Brain Repair and Rehabilitation (C.Z.), Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; the Perinatal Center (Y.C., H.H.), Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hagberg","sequence":"additional","affiliation":[{"name":"From the Perinatal Center (X.W., W.H., X.D., Y.C., C.M., E.J., H.H.), Department of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; the Department of Pediatrics (X.W., W.H., X.D., C.Z.), The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China; the Center for Brain Repair and Rehabilitation (C.Z.), Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden; the Perinatal Center (Y.C., H.H.), Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2005.08.040"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2665"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0883073809338212"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402053"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5832-08.2009"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401871"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0350797"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-14-05910.2002"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2008.04.007"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607207103"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2652"},{"key":"e_1_3_3_12_2","doi-asserted-by":"crossref","unstructured":"van der Kooij MA Ohl F Arndt SS Kavelaars A van Bel F Heijnen CJ. Mild neonatal hypoxia\u2013ischemia induces long-term motor- and cognitive impairments in mice. Brain Behav Immun. 2009.","DOI":"10.1016\/j.bbi.2009.09.003"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000151122.58665.70"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.08.003"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306289200"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.049924"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.038166"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-06-01931.2001"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402025"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0403-281"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00386-4"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(00)00005-8"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.06.005"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.110.589051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:19:35Z","timestamp":1715609975000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.110.589051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["10.1161\/STROKEAHA.110.589051"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.110.589051","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"2010-04-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-06-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-07-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}