{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:35:54Z","timestamp":1783467354812,"version":"3.55.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Intracranial large artery disease (ICLAD) is a major cause of ischemic stroke. Retinal microvascular changes are associated with stroke, including small vessel cerebral disease and extracranial carotid disease. We examined the relationship between ICLAD and retinal microvascular changes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>This is a prospective cohort of 802 acute ischemic stroke patients. Retinal changes were assessed from photographs by graders masked to clinical data. ICLAD was evaluated using prespecified criteria.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              ICLAD was not associated with ipsilateral retinal arteriolar\/venular caliber, focal arteriolar narrowing, or arteriovenous nicking. Severe enhanced arteriolar light reflex was independently associated with any ICLAD (\n              <jats:italic>P<\/jats:italic>\n              =0.006) and severe ICLAD (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>Enhanced arteriolar light reflex, but not retinal vessel caliber, was related to ICLAD. These data suggest that retinal microvascular signs have specific associations with large cerebral vessel disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.110.589960","type":"journal-article","created":{"date-parts":[[2011,1,22]],"date-time":"2011-01-22T05:07:57Z","timestamp":1295672877000},"page":"812-814","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Associations of Retinal Microvascular Signs and Intracranial Large Artery Disease"],"prefix":"10.1161","volume":"42","author":[{"given":"Deidre A.","family":"De Silva","sequence":"first","affiliation":[{"name":"From the Singapore General Hospital Campus (D.A.D., H.M.C., J.J.F.M.), National Neuroscience Institute, Singapore; National Heart Centre Singapore (F.-P.W.), Singapore; Singapore Eye Research Institute (E.Y.L., T.-Y.W.), Singapore; Singapore General Hospital (M.-P.L., H.-Y.G.), Singapore; National University of Singapore (C.P.L.H.C., T.-Y.W.), Singapore; Centre for Vision Research (P.M., J.J.W.), Westmead Millennium Institute, University of Sydney, Sydney, Australia; Center for Eye Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer J.F.","family":"Manzano","sequence":"additional","affiliation":[{"name":"From the Singapore General Hospital Campus (D.A.D., H.M.C., J.J.F.M.), National Neuroscience Institute, Singapore; National Heart Centre Singapore (F.-P.W.), Singapore; Singapore Eye Research Institute (E.Y.L., T.-Y.W.), Singapore; Singapore General Hospital (M.-P.L., H.-Y.G.), Singapore; National University of Singapore (C.P.L.H.C., T.-Y.W.), Singapore; Centre for Vision Research (P.M., J.J.W.), Westmead Millennium Institute, University of Sydney, Sydney, Australia; Center for Eye Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fung-Peng","family":"Woon","sequence":"additional","affiliation":[{"name":"From the Singapore General Hospital Campus (D.A.D., H.M.C., J.J.F.M.), National Neuroscience Institute, Singapore; National Heart Centre Singapore (F.-P.W.), Singapore; Singapore Eye Research Institute (E.Y.L., T.-Y.W.), Singapore; Singapore General Hospital (M.-P.L., H.-Y.G.), Singapore; National University of Singapore (C.P.L.H.C., T.-Y.W.), Singapore; Centre for Vision Research (P.M., J.J.W.), Westmead Millennium Institute, University of Sydney, Sydney, Australia; Center for Eye Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"From the Singapore General Hospital Campus (D.A.D., H.M.C., J.J.F.M.), National Neuroscience Institute, Singapore; National Heart Centre Singapore (F.-P.W.), Singapore; Singapore Eye Research Institute (E.Y.L., T.-Y.W.), Singapore; Singapore General Hospital (M.-P.L., H.-Y.G.), Singapore; National University of Singapore (C.P.L.H.C., T.-Y.W.), Singapore; Centre for Vision Research (P.M., J.J.W.), Westmead Millennium Institute, University of Sydney, Sydney, Australia; Center for Eye Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moi-Pin","family":"Lee","sequence":"additional","affiliation":[{"name":"From the Singapore General Hospital Campus (D.A.D., H.M.C., J.J.F.M.), National Neuroscience Institute, Singapore; National Heart Centre Singapore (F.-P.W.), Singapore; Singapore Eye Research Institute (E.Y.L., T.-Y.W.), Singapore; Singapore General Hospital (M.-P.L., H.-Y.G.), Singapore; National University of Singapore (C.P.L.H.C., T.-Y.W.), Singapore; Centre for Vision Research (P.M., J.J.W.), Westmead Millennium Institute, University of Sydney, Sydney, Australia; Center for Eye Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Yee","family":"Gan","sequence":"additional","affiliation":[{"name":"From the Singapore General Hospital Campus (D.A.D., H.M.C., J.J.F.M.), National Neuroscience Institute, Singapore; National Heart Centre Singapore (F.-P.W.), Singapore; Singapore Eye Research Institute (E.Y.L., T.-Y.W.), Singapore; Singapore General Hospital (M.-P.L., H.-Y.G.), Singapore; National University of Singapore (C.P.L.H.C., T.-Y.W.), Singapore; Centre for Vision Research (P.M., J.J.W.), Westmead Millennium Institute, University of Sydney, Sydney, Australia; Center for Eye Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.L.H.","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Singapore General Hospital Campus (D.A.D., H.M.C., J.J.F.M.), National Neuroscience Institute, Singapore; National Heart Centre Singapore (F.-P.W.), Singapore; Singapore Eye Research Institute (E.Y.L., T.-Y.W.), Singapore; Singapore General Hospital (M.-P.L., H.-Y.G.), Singapore; National University of Singapore (C.P.L.H.C., T.-Y.W.), Singapore; Centre for Vision Research (P.M., J.J.W.), Westmead Millennium Institute, University of Sydney, Sydney, Australia; Center for Eye Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Meng","family":"Chang","sequence":"additional","affiliation":[{"name":"From the Singapore General Hospital Campus (D.A.D., H.M.C., J.J.F.M.), National Neuroscience Institute, Singapore; National Heart Centre Singapore (F.-P.W.), Singapore; Singapore Eye Research Institute (E.Y.L., T.-Y.W.), Singapore; Singapore General Hospital (M.-P.L., H.-Y.G.), Singapore; National University of Singapore (C.P.L.H.C., T.-Y.W.), Singapore; Centre for Vision Research (P.M., J.J.W.), Westmead Millennium Institute, University of Sydney, Sydney, Australia; Center for Eye Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Mitchell","sequence":"additional","affiliation":[{"name":"From the Singapore General Hospital Campus (D.A.D., H.M.C., J.J.F.M.), National Neuroscience Institute, Singapore; National Heart Centre Singapore (F.-P.W.), Singapore; Singapore Eye Research Institute (E.Y.L., T.-Y.W.), Singapore; Singapore General Hospital (M.-P.L., H.-Y.G.), Singapore; National University of Singapore (C.P.L.H.C., T.-Y.W.), Singapore; Centre for Vision Research (P.M., J.J.W.), Westmead Millennium Institute, University of Sydney, Sydney, Australia; Center for Eye Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"From the Singapore General Hospital Campus (D.A.D., H.M.C., J.J.F.M.), National Neuroscience Institute, Singapore; National Heart Centre Singapore (F.-P.W.), Singapore; Singapore Eye Research Institute (E.Y.L., T.-Y.W.), Singapore; Singapore General Hospital (M.-P.L., H.-Y.G.), Singapore; National University of Singapore (C.P.L.H.C., T.-Y.W.), Singapore; Centre for Vision Research (P.M., J.J.W.), Westmead Millennium Institute, University of Sydney, Sydney, Australia; Center for Eye Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard I.","family":"Lindley","sequence":"additional","affiliation":[{"name":"From the Singapore General Hospital Campus (D.A.D., H.M.C., J.J.F.M.), National Neuroscience Institute, Singapore; National Heart Centre Singapore (F.-P.W.), Singapore; Singapore Eye Research Institute (E.Y.L., T.-Y.W.), Singapore; Singapore General Hospital (M.-P.L., H.-Y.G.), Singapore; National University of Singapore (C.P.L.H.C., T.-Y.W.), Singapore; Centre for Vision Research (P.M., J.J.W.), Westmead Millennium Institute, University of Sydney, Sydney, Australia; Center for Eye Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien-Yin","family":"Wong","sequence":"additional","affiliation":[{"name":"From the Singapore General Hospital Campus (D.A.D., H.M.C., J.J.F.M.), National Neuroscience Institute, Singapore; National Heart Centre Singapore (F.-P.W.), Singapore; Singapore Eye Research Institute (E.Y.L., T.-Y.W.), Singapore; Singapore General Hospital (M.-P.L., H.-Y.G.), Singapore; National University of Singapore (C.P.L.H.C., T.-Y.W.), Singapore; Centre for Vision Research (P.M., J.J.W.), Westmead Millennium Institute, University of Sydney, Sydney, Australia; Center for Eye Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Cheong","family":"Wong","sequence":"additional","affiliation":[{"name":"From the Singapore General Hospital Campus (D.A.D., H.M.C., J.J.F.M.), National Neuroscience Institute, Singapore; National Heart Centre Singapore (F.-P.W.), Singapore; Singapore Eye Research Institute (E.Y.L., T.-Y.W.), Singapore; Singapore General Hospital (M.-P.L., H.-Y.G.), Singapore; National University of Singapore (C.P.L.H.C., T.-Y.W.), Singapore; Centre for Vision Research (P.M., J.J.W.), Westmead Millennium Institute, University of Sydney, Sydney, Australia; Center for Eye Research..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2006.00045.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70131-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.109.559435"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.27.3.143.16049"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.06.046"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.11.2641"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000070108"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.32.5.1079"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.110.589960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:42:03Z","timestamp":1715611323000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.110.589960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["10.1161\/STROKEAHA.110.589960"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.110.589960","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3]]},"assertion":[{"value":"2010-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-10-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-01-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}