{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:05:04Z","timestamp":1791115504703,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Carotid endarterectomy (CEA) has become a routine procedure to treat symptomatic carotid artery disease and reduce the risk of recurrent cerebral ischemic events. The purpose of this study was to use an arterial spin labeling dynamic magnetic resonance angiography technique to characterize intracranial hemodynamics before and after CEA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Thirty-seven carotid artery disease patients participated in this study, of whom 24 underwent magnetic resonance imaging before and after CEA. Seventeen control subjects spanning 5 decades underwent magnetic resonance imaging to assess age-related changes. Hemodynamic metrics (that is, relative time to peak and amplitude) were calculated with a \u03b3-variate model. Linear regression was used to relate carotid artery disease burden to downstream hemodynamics in the circle of Willis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              Relative time to peak increased with age in controls (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.020). For patients, relative time to peak was positively correlated with percent stenosis (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.050), independent of age. At 1 day after CEA, the middle cerebral artery ipsilateral to the CEA showed significant dynamic magnetic resonance angiography changes: relative time to peak decreased (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.017) and the flow amplitude increased (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.009). No pre- versus post-CEA changes were significant in the contralateral middle cerebral artery or posterior segments.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>This noninvasive, arterial spin labeling\u2013based method produced time-resolved images that were used to characterize intracranial arterial flow associated with aging, extracranial carotid artery disease, and CEA. Results demonstrate that the technique has the sensitivity to detect hemodynamic changes after CEA.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.110.590786","type":"journal-article","created":{"date-parts":[[2011,2,25]],"date-time":"2011-02-25T04:22:30Z","timestamp":1298607750000},"page":"979-984","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Intracranial Hemodynamics Is Altered by Carotid Artery Disease and After Endarterectomy"],"prefix":"10.1161","volume":"42","author":[{"given":"Bradley J.","family":"MacIntosh","sequence":"first","affiliation":[{"name":"From the Department of Clinical Neurology (B.J.M., M.J.D., M.A.C., P.J.), FMRIB Centre, Oxfordshire, England; Nuffield Department of Surgery (E.S., A.H.) and Acute Stroke Programme (E.S., J.K.), Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxfordshire, England; Department of Medical Biophysics (B.J.M.), University of Toronto, Toronto, Canada; and Department of Neurology (M.G.), University Hospital Mannheim, University of Heidelberg, and Mediri GmbH,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ediri","family":"Sideso","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Neurology (B.J.M., M.J.D., M.A.C., P.J.), FMRIB Centre, Oxfordshire, England; Nuffield Department of Surgery (E.S., A.H.) and Acute Stroke Programme (E.S., J.K.), Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxfordshire, England; Department of Medical Biophysics (B.J.M.), University of Toronto, Toronto, Canada; and Department of Neurology (M.G.), University Hospital Mannheim, University of Heidelberg, and Mediri GmbH,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manus J.","family":"Donahue","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Neurology (B.J.M., M.J.D., M.A.C., P.J.), FMRIB Centre, Oxfordshire, England; Nuffield Department of Surgery (E.S., A.H.) and Acute Stroke Programme (E.S., J.K.), Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxfordshire, England; Department of Medical Biophysics (B.J.M.), University of Toronto, Toronto, Canada; and Department of Neurology (M.G.), University Hospital Mannheim, University of Heidelberg, and Mediri GmbH,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Chappell","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Neurology (B.J.M., M.J.D., M.A.C., P.J.), FMRIB Centre, Oxfordshire, England; Nuffield Department of Surgery (E.S., A.H.) and Acute Stroke Programme (E.S., J.K.), Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxfordshire, England; Department of Medical Biophysics (B.J.M.), University of Toronto, Toronto, Canada; and Department of Neurology (M.G.), University Hospital Mannheim, University of Heidelberg, and Mediri GmbH,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Neurology (B.J.M., M.J.D., M.A.C., P.J.), FMRIB Centre, Oxfordshire, England; Nuffield Department of Surgery (E.S., A.H.) and Acute Stroke Programme (E.S., J.K.), Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxfordshire, England; Department of Medical Biophysics (B.J.M.), University of Toronto, Toronto, Canada; and Department of Neurology (M.G.), University Hospital Mannheim, University of Heidelberg, and Mediri GmbH,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Handa","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Neurology (B.J.M., M.J.D., M.A.C., P.J.), FMRIB Centre, Oxfordshire, England; Nuffield Department of Surgery (E.S., A.H.) and Acute Stroke Programme (E.S., J.K.), Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxfordshire, England; Department of Medical Biophysics (B.J.M.), University of Toronto, Toronto, Canada; and Department of Neurology (M.G.), University Hospital Mannheim, University of Heidelberg, and Mediri GmbH,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Kennedy","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Neurology (B.J.M., M.J.D., M.A.C., P.J.), FMRIB Centre, Oxfordshire, England; Nuffield Department of Surgery (E.S., A.H.) and Acute Stroke Programme (E.S., J.K.), Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxfordshire, England; Department of Medical Biophysics (B.J.M.), University of Toronto, Toronto, Canada; and Department of Neurology (M.G.), University Hospital Mannheim, University of Heidelberg, and Mediri GmbH,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Jezzard","sequence":"additional","affiliation":[{"name":"From the Department of Clinical Neurology (B.J.M., M.J.D., M.A.C., P.J.), FMRIB Centre, Oxfordshire, England; Nuffield Department of Surgery (E.S., A.H.) and Acute Stroke Programme (E.S., J.K.), Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxfordshire, England; Department of Medical Biophysics (B.J.M.), University of Toronto, Toronto, Canada; and Department of Neurology (M.G.), University Hospital Mannheim, University of Heidelberg, and Mediri GmbH,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.4.754"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811123392002"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2003.11.002"},{"key":"e_1_3_4_5_2","first-page":"47","article-title":"Ischemia after carotid endarterectomy: comparison between transcranial Doppler sonography and diffusion-weighted MR imaging","volume":"21","author":"Muller M","year":"2000","unstructured":"Muller M, Reiche W, Langenscheidt P, Hassfeld J, Hagen T. 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