{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:06:37Z","timestamp":1786579597408,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            The pivotal National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator trials excluded patients with ischemic stroke with specific minor presentations or rapidly improving symptoms. The recombinant tissue plasminogen activator product label notes that its use for minor neurological deficit or rapidly improving stroke symptoms has not been evaluated. As a result, patients with low National Institutes of Health Stroke Scale scores are not commonly treated in clinical practice. We sought to further characterize the patients with minor stroke who were included in the National Institute of Neurological Disorders and Stroke trials.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            Minor strokes were defined as National Institutes of Health Stroke Scale score \u22645 at baseline for this retrospective analysis, because this subgroup is most commonly excluded from treatment in clinical practice and trials. Clinical stroke syndromes were defined based on prespecified National Institutes of Health Stroke Scale item score clusters. Clinical outcomes were reviewed generally and within these cluster subgroups.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Only 58 cases had National Institutes of Health Stroke Scale scores of 0 to 5 in the National Institute of Neurological Disorders and Stroke trials (42 recombinant tissue plasminogen activator and 16 placebo), and 2971 patients were excluded from the trials due to \u201crapidly improving\u201d or \u201cminor symptoms\u201d as the primary reason. No patients were enrolled with isolated motor symptoms, isolated facial droop, isolated ataxia, dysarthria, isolated sensory symptoms, or with only symptoms\/signs not captured by the National Institutes of Health Stroke Scale score (ie, National Institutes of Health Stroke Scale=0). There were \u22643 patients with each of the other isolated deficits enrolled in the trial.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            The National Institute of Neurological Disorders and Stroke trials excluded a substantial number of strokes with minor presentations, those that were included were small in number, and conclusions about outcomes based on specific syndromes cannot be drawn. Further prospective, systematic study of this subgroup is needed.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.110.593632","type":"journal-article","created":{"date-parts":[[2010,9,3]],"date-time":"2010-09-03T02:43:02Z","timestamp":1283481782000},"page":"2581-2586","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":80,"title":["Strokes With Minor Symptoms"],"prefix":"10.1161","volume":"41","author":[{"given":"Pooja","family":"Khatri","sequence":"first","affiliation":[{"name":"From the University of Cincinnati (P.K., D.O.K., C.J.M., J.P.B.), Cincinnati, Ohio; the Medical University of South Carolina (S.D.Y., E.C.J., Y.Y.P.), Charleston, SC; the University of California\u2013Los Angeles (J.L.S.), Los Angeles, Calif; Mount Sinai Medical Center (S.R.L.); and Cedars Sinai Medical Center (P.D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn O.","family":"Kleindorfer","sequence":"additional","affiliation":[{"name":"From the University of Cincinnati (P.K., D.O.K., C.J.M., J.P.B.), Cincinnati, Ohio; the Medical University of South Carolina (S.D.Y., E.C.J., Y.Y.P.), Charleston, SC; the University of California\u2013Los Angeles (J.L.S.), Los Angeles, Calif; Mount Sinai Medical Center (S.R.L.); and Cedars Sinai Medical Center (P.D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon D.","family":"Yeatts","sequence":"additional","affiliation":[{"name":"From the University of Cincinnati (P.K., D.O.K., C.J.M., J.P.B.), Cincinnati, Ohio; the Medical University of South Carolina (S.D.Y., E.C.J., Y.Y.P.), Charleston, SC; the University of California\u2013Los Angeles (J.L.S.), Los Angeles, Calif; Mount Sinai Medical Center (S.R.L.); and Cedars Sinai Medical Center (P.D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Saver","sequence":"additional","affiliation":[{"name":"From the University of Cincinnati (P.K., D.O.K., C.J.M., J.P.B.), Cincinnati, Ohio; the Medical University of South Carolina (S.D.Y., E.C.J., Y.Y.P.), Charleston, SC; the University of California\u2013Los Angeles (J.L.S.), Los Angeles, Calif; Mount Sinai Medical Center (S.R.L.); and Cedars Sinai Medical Center (P.D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Levine","sequence":"additional","affiliation":[{"name":"From the University of Cincinnati (P.K., D.O.K., C.J.M., J.P.B.), Cincinnati, Ohio; the Medical University of South Carolina (S.D.Y., E.C.J., Y.Y.P.), Charleston, SC; the University of California\u2013Los Angeles (J.L.S.), Los Angeles, Calif; Mount Sinai Medical Center (S.R.L.); and Cedars Sinai Medical Center (P.D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick D.","family":"Lyden","sequence":"additional","affiliation":[{"name":"From the University of Cincinnati (P.K., D.O.K., C.J.M., J.P.B.), Cincinnati, Ohio; the Medical University of South Carolina (S.D.Y., E.C.J., Y.Y.P.), Charleston, SC; the University of California\u2013Los Angeles (J.L.S.), Los Angeles, Calif; Mount Sinai Medical Center (S.R.L.); and Cedars Sinai Medical Center (P.D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J.","family":"Moomaw","sequence":"additional","affiliation":[{"name":"From the University of Cincinnati (P.K., D.O.K., C.J.M., J.P.B.), Cincinnati, Ohio; the Medical University of South Carolina (S.D.Y., E.C.J., Y.Y.P.), Charleston, SC; the University of California\u2013Los Angeles (J.L.S.), Los Angeles, Calif; Mount Sinai Medical Center (S.R.L.); and Cedars Sinai Medical Center (P.D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko Y.","family":"Palesch","sequence":"additional","affiliation":[{"name":"From the University of Cincinnati (P.K., D.O.K., C.J.M., J.P.B.), Cincinnati, Ohio; the Medical University of South Carolina (S.D.Y., E.C.J., Y.Y.P.), Charleston, SC; the University of California\u2013Los Angeles (J.L.S.), Los Angeles, Calif; Mount Sinai Medical Center (S.R.L.); and Cedars Sinai Medical Center (P.D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward C.","family":"Jauch","sequence":"additional","affiliation":[{"name":"From the University of Cincinnati (P.K., D.O.K., C.J.M., J.P.B.), Cincinnati, Ohio; the Medical University of South Carolina (S.D.Y., E.C.J., Y.Y.P.), Charleston, SC; the University of California\u2013Los Angeles (J.L.S.), Los Angeles, Calif; Mount Sinai Medical Center (S.R.L.); and Cedars Sinai Medical Center (P.D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Broderick","sequence":"additional","affiliation":[{"name":"From the University of Cincinnati (P.K., D.O.K., C.J.M., J.P.B.), Cincinnati, Ohio; the Medical University of South Carolina (S.D.Y., E.C.J., Y.Y.P.), Charleston, SC; the University of California\u2013Los Angeles (J.L.S.), Los Angeles, Calif; Mount Sinai Medical Center (S.R.L.); and Cedars Sinai Medical Center (P.D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199512143332401"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2005.02.013"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.107.181486"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000109767.11426.17"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.109.549576"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.503334"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2007.00143.x"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.108.517656"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000227191.01792.e3"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.491852"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.8.1015"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000152041.20486.2F"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.9.1151"},{"key":"e_1_3_2_14_2","first-page":"1","volume":"58","year":"2009","unstructured":"George MG, Tong X, McGruder H, Yoon P, Rosamond W, Winquist A, Hinchey J, Wall HK, Pandey DK; 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Stroke. 2008; 39.","journal-title":"Stroke"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.572883"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1997.00550240020008"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000140891.70547.56"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.482554"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000237520.88777.71"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.110.593632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:19:50Z","timestamp":1715609990000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.110.593632"}},"subtitle":["An Exploratory Analysis of the National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Trials"],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1161\/STROKEAHA.110.593632"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.110.593632","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"2010-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-06-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}