{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:54:35Z","timestamp":1791237275961,"version":"4.1.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Randomized trials suggested a different benefit of intravenous thrombolysis (IVT) and intra-arterial thrombolysis (IAT) between men and women with anterior circulation stroke because of a worse outcome of women in the control group.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            We compared outcome and recanalization in men and women with basilar artery occlusion treated with antithrombotic treatment alone, IVT or combined IVT\u2013IAT, or IAT in the Basilar Artery International Cooperation Study.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Overall, 389 male and 226 female patients were analyzed. In the antithrombotic treatment group, 68 of 111 (61%) men and 47 of 70 (67%) women had a poor outcome defined as a modified Rankin Scale score of 4 to 6 (adjusted risk ratio [aRR], 0.96; 95% CI, 0.75 to 1.24), in the IVT\/combined IVT\u2013IAT group, 47 of 77 (61%) men and 24 of 43 (56%) women (aRR, 1.19; 95% CI, 0.89 to 1.60), and in the IAT group, 142 of 185 (77%) men and 71 of 102 (70%) women (aRR, 1.01; 95% CI, 0.88 to 1.17). Mortality was not different between men and women in the antithrombotic treatment group (aRR, 0.80; 95% CI, 0.55 to 1.16), the IVT\/combined IVT\u2013IAT group (aRR, 1.11; 95% CI, 0.72 to 1.73), or in the IAT group (aRR, 1.01; 95% CI, 0.75 to 1.36). Insufficient recanalization after combined IVT\u2013IAT or IAT was similar in men and women (23% versus 22%; aRR, 0.92; 95% CI, 0.58 to 1.46).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            In patients with acute basilar artery occlusion, no significant gender differences for outcome and recanalization were observed, regardless of treatment modality.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.110.594036","type":"journal-article","created":{"date-parts":[[2010,10,15]],"date-time":"2010-10-15T02:56:24Z","timestamp":1287111384000},"page":"2693-2696","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Acute Basilar Artery Occlusion in the Basilar Artery International Cooperation Study"],"prefix":"10.1161","volume":"41","author":[{"given":"Marcel","family":"Arnold","sequence":"first","affiliation":[{"name":"From the Department of Neurology (M.A., U.F., O.F., H.P.M.), Inselspital, University of Bern, Bern, Switzerland; Department of Neurology (A.C., L.J.K., A.A., W.J.S.), University Medical Centre Utrecht and Rudolf Magnus Institute of Neurosciences, The Netherlands; Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, University of Bern, Bern, Switzerland; Stroke Center (D.T.), Department of Neurology, Chaim Sheba Medical Center and Tel Aviv University, Tel-Hashomer, Israel;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Fischer","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., U.F., O.F., H.P.M.), Inselspital, University of Bern, Bern, Switzerland; Department of Neurology (A.C., L.J.K., A.A., W.J.S.), University Medical Centre Utrecht and Rudolf Magnus Institute of Neurosciences, The Netherlands; Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, University of Bern, Bern, Switzerland; Stroke Center (D.T.), Department of Neurology, Chaim Sheba Medical Center and Tel Aviv University, Tel-Hashomer, Israel;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Compter","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., U.F., O.F., H.P.M.), Inselspital, University of Bern, Bern, Switzerland; Department of Neurology (A.C., L.J.K., A.A., W.J.S.), University Medical Centre Utrecht and Rudolf Magnus Institute of Neurosciences, The Netherlands; Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, University of Bern, Bern, Switzerland; Stroke Center (D.T.), Department of Neurology, Chaim Sheba Medical Center and Tel Aviv University, Tel-Hashomer, Israel;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Gralla","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., U.F., O.F., H.P.M.), Inselspital, University of Bern, Bern, Switzerland; Department of Neurology (A.C., L.J.K., A.A., W.J.S.), University Medical Centre Utrecht and Rudolf Magnus Institute of Neurosciences, The Netherlands; Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, University of Bern, Bern, Switzerland; Stroke Center (D.T.), Department of Neurology, Chaim Sheba Medical Center and Tel Aviv University, Tel-Hashomer, Israel;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Findling","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., U.F., O.F., H.P.M.), Inselspital, University of Bern, Bern, Switzerland; Department of Neurology (A.C., L.J.K., A.A., W.J.S.), University Medical Centre Utrecht and Rudolf Magnus Institute of Neurosciences, The Netherlands; Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, University of Bern, Bern, Switzerland; Stroke Center (D.T.), Department of Neurology, Chaim Sheba Medical Center and Tel Aviv University, Tel-Hashomer, Israel;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich P.","family":"Mattle","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., U.F., O.F., H.P.M.), Inselspital, University of Bern, Bern, Switzerland; Department of Neurology (A.C., L.J.K., A.A., W.J.S.), University Medical Centre Utrecht and Rudolf Magnus Institute of Neurosciences, The Netherlands; Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, University of Bern, Bern, Switzerland; Stroke Center (D.T.), Department of Neurology, Chaim Sheba Medical Center and Tel Aviv University, Tel-Hashomer, Israel;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Jaap","family":"Kappelle","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., U.F., O.F., H.P.M.), Inselspital, University of Bern, Bern, Switzerland; Department of Neurology (A.C., L.J.K., A.A., W.J.S.), University Medical Centre Utrecht and Rudolf Magnus Institute of Neurosciences, The Netherlands; Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, University of Bern, Bern, Switzerland; Stroke Center (D.T.), Department of Neurology, Chaim Sheba Medical Center and Tel Aviv University, Tel-Hashomer, Israel;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tanne","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., U.F., O.F., H.P.M.), Inselspital, University of Bern, Bern, Switzerland; Department of Neurology (A.C., L.J.K., A.A., W.J.S.), University Medical Centre Utrecht and Rudolf Magnus Institute of Neurosciences, The Netherlands; Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, University of Bern, Bern, Switzerland; Stroke Center (D.T.), Department of Neurology, Chaim Sheba Medical Center and Tel Aviv University, Tel-Hashomer, Israel;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ale","family":"Algra","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., U.F., O.F., H.P.M.), Inselspital, University of Bern, Bern, Switzerland; Department of Neurology (A.C., L.J.K., A.A., W.J.S.), University Medical Centre Utrecht and Rudolf Magnus Institute of Neurosciences, The Netherlands; Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, University of Bern, Bern, Switzerland; Stroke Center (D.T.), Department of Neurology, Chaim Sheba Medical Center and Tel Aviv University, Tel-Hashomer, Israel;..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter J.","family":"Schonewille","sequence":"additional","affiliation":[{"name":"From the Department of Neurology (M.A., U.F., O.F., H.P.M.), Inselspital, University of Bern, Bern, Switzerland; Department of Neurology (A.C., L.J.K., A.A., W.J.S.), University Medical Centre Utrecht and Rudolf Magnus Institute of Neurosciences, The Netherlands; Institute of Diagnostic and Interventional Neuroradiology (J.G.), Inselspital, University of Bern, Bern, Switzerland; Stroke Center (D.T.), Department of Neurology, Chaim Sheba Medical Center and Tel Aviv University, Tel-Hashomer, Israel;..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000068410.07397.d7"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000082999"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000150515.15576.29"},{"key":"e_1_3_3_4_2","first-page":"1322","volume":"37","year":"2006","unstructured":"Hill MD, Kent DM, Hinchey J, Rowley H, Buchan AM, Wechsler LR, Higashida RT, Fischbein NJ, Dillon WP, Gent M, Firszt CM, Schulz GA, Furlan AJ; PROACT-2 investigators. 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