{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:15:59Z","timestamp":1792300559969,"version":"4.4.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>Endothelial progenitor cells (EPC) are important participants of neovascularization and are mobilized through signaling with stromal-derived factor (SDF-1\u03b1), vascular endothelial growth factor (VEGF), granulocyte colony-stimulating factor, and stem cell factor. The association between EPC levels and these growth factors (GF) in acute stroke has not been previously established. We aimed to determine the association between EPC and these GF, and to elucidate a relationship between these GF and stroke severity in acute stroke patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>Seventeen patients were selected from 175 patients with imaging-confirmed acute ischemic stroke. EPC were quantified using CD34, CD133, and VEGF-R2 markers. Plasma VEGF, SDF-1\u03b1, granulocyte colony-stimulating factor, and stem cell factor were determined by enzyme-linked immunosorbent assay on days 1 and 3, and brain MRI was performed at baseline and on days 1 and 5 after the stroke onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>\n                      Levels of SDF-1\u03b1 strongly (\n                      <jats:italic>r<\/jats:italic>\n                      =0.6) correlated with the numbers of EPC subsets CD133\n                      <jats:sup>+<\/jats:sup>\n                      VEFG-R2\n                      <jats:sup>+<\/jats:sup>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.004), CD34\n                      <jats:sup>+<\/jats:sup>\n                      VEGF-R2\n                      <jats:sup>+<\/jats:sup>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01), and CD34\n                      <jats:sup>+<\/jats:sup>\n                      CD133\n                      <jats:sup>+<\/jats:sup>\n                      VEGF-R2\n                      <jats:sup>+<\/jats:sup>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01) on day 1. Stem cell factor strongly (\n                      <jats:italic>r<\/jats:italic>\n                      =0.5) correlated with CD133\n                      <jats:sup>+<\/jats:sup>\n                      VEGF-R2\n                      <jats:sup>+<\/jats:sup>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.05). SDF-1\u03b1 moderately inversely (\n                      <jats:italic>r<\/jats:italic>\n                      =\u22120.49) correlated with baseline diffusion-weighted imaging lesion volumes (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.04). Median levels of SDF-1\u03b1 (1561 pg\/mL) increased (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.04) on day 3 compared to day 1 (1379 pg\/mL). Similarly, VEGF at day 3 (95 pg\/mL) increased (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.03) compared to day 1 (64 pg\/mL).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>These results indicate that SDF-1\u03b1 and stem cell factor correlate with an increase in EPC early in ischemic stroke patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.110.596007","type":"journal-article","created":{"date-parts":[[2011,1,22]],"date-time":"2011-01-22T00:07:57Z","timestamp":1295654877000},"page":"618-625","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":67,"title":["Stromal-Derived Factor-1\u03b1 Correlates With Circulating Endothelial Progenitor Cells and With Acute Lesion Volume in Stroke Patients"],"prefix":"10.1161","volume":"42","author":[{"given":"Tanya","family":"Bogoslovsky","sequence":"first","affiliation":[{"name":"From the Stroke Diagnostics and Therapeutics Section (T.B., M.L., S.W.), Stroke Branch (M.S.), NINDS Flow Cytometry Core Facility (D.M.), National Institute of Neurological Disorders and Stroke, Frank Laboratory (A.C., J.F.), Clinical Center, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Spatz","sequence":"additional","affiliation":[{"name":"From the Stroke Diagnostics and Therapeutics Section (T.B., M.L., S.W.), Stroke Branch (M.S.), NINDS Flow Cytometry Core Facility (D.M.), National Institute of Neurological Disorders and Stroke, Frank Laboratory (A.C., J.F.), Clinical Center, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneeka","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"From the Stroke Diagnostics and Therapeutics Section (T.B., M.L., S.W.), Stroke Branch (M.S.), NINDS Flow Cytometry Core Facility (D.M.), National Institute of Neurological Disorders and Stroke, Frank Laboratory (A.C., J.F.), Clinical Center, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragan","family":"Maric","sequence":"additional","affiliation":[{"name":"From the Stroke Diagnostics and Therapeutics Section (T.B., M.L., S.W.), Stroke Branch (M.S.), NINDS Flow Cytometry Core Facility (D.M.), National Institute of Neurological Disorders and Stroke, Frank Laboratory (A.C., J.F.), Clinical Center, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Luby","sequence":"additional","affiliation":[{"name":"From the Stroke Diagnostics and Therapeutics Section (T.B., M.L., S.W.), Stroke Branch (M.S.), NINDS Flow Cytometry Core Facility (D.M.), National Institute of Neurological Disorders and Stroke, Frank Laboratory (A.C., J.F.), Clinical Center, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Frank","sequence":"additional","affiliation":[{"name":"From the Stroke Diagnostics and Therapeutics Section (T.B., M.L., S.W.), Stroke Branch (M.S.), NINDS Flow Cytometry Core Facility (D.M.), National Institute of Neurological Disorders and Stroke, Frank Laboratory (A.C., J.F.), Clinical Center, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Warach","sequence":"additional","affiliation":[{"name":"From the Stroke Diagnostics and Therapeutics Section (T.B., M.L., S.W.), Stroke Branch (M.S.), NINDS Flow Cytometry Core Facility (D.M.), National Institute of Neurological Disorders and Stroke, Frank Laboratory (A.C., J.F.), Clinical Center, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, 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