{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:31:09Z","timestamp":1792791069133,"version":"4.5.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>\n            <jats:bold>\n              <jats:italic>Background and Purpose\u2014<\/jats:italic>\n            <\/jats:bold>\n            Stroke registries are valuable tools for obtaining information about stroke epidemiology and management. The Acute STroke Registry and Analysis of Lausanne (ASTRAL) prospectively collects epidemiological, clinical, laboratory and multimodal brain imaging data of acute ischemic stroke patients in the Centre Hospitalier Universitaire Vaudois (CHUV). Here, we provide design and methods used to create ASTRAL and present baseline data of our patients (2003 to 2008).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Methods\u2014<\/jats:italic>\n            <\/jats:bold>\n            All consecutive patients admitted to CHUV between January 1, 2003 and December 31, 2008 with acute ischemic stroke within 24 hours of symptom onset were included in ASTRAL. Patients arriving beyond 24 hours, with transient ischemic attack, intracerebral hemorrhage, subarachnoidal hemorrhage, or cerebral sinus venous thrombosis, were excluded. Recurrent ischemic strokes were registered as new events.\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Results\u2014<\/jats:italic>\n            <\/jats:bold>\n            Between 2003 and 2008, 1633 patients and 1742 events were registered in ASTRAL. There was a preponderance of males, even in the elderly. Cardioembolic stroke was the most frequent type of stroke. Most strokes were of minor severity (National Institute of Health Stroke Scale [NIHSS] score \u22644 in 40.8% of patients). Cardioembolic stroke and dissections presented with the most severe clinical picture. There was a significant number of patients with unknown onset stroke, including wake-up stroke (n=568, 33.1%). Median time from last-well time to hospital arrival was 142 minutes for known onset and 759 minutes for unknown-onset stroke. The rate of intravenous or intraarterial thrombolysis between 2003 and 2008 increased from 10.8% to 20.8% in patients admitted within 24 hours of last-well time. Acute brain imaging was performed in 1695 patients (97.3%) within 24 hours. In 1358 patients (78%) who underwent acute computed tomography angiography, 717 patients (52.8%) had significant abnormalities. Of the 1068 supratentorial stroke patients who underwent acute perfusion computed tomography (61.3%), focal hypoperfusion was demonstrated in 786 patients (73.6%).\n          <\/jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>Conclusions\u2014<\/jats:italic>\n            <\/jats:bold>\n            This hospital-based prospective registry of consecutive acute ischemic strokes incorporates demographic, clinical, metabolic, acute perfusion, and arterial imaging. It is characterized by a high proportion of minor and unknown-onset strokes, short onset-to-admission time for known-onset patients, rapidly increasing thrombolysis rates, and significant vascular and perfusion imaging abnormalities in the majority of patients.\n          <\/jats:p>","DOI":"10.1161\/strokeaha.110.596189","type":"journal-article","created":{"date-parts":[[2010,10,8]],"date-time":"2010-10-08T03:05:48Z","timestamp":1286507148000},"page":"2491-2498","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":226,"title":["The Acute STroke Registry and Analysis of Lausanne (ASTRAL)"],"prefix":"10.1161","volume":"41","author":[{"given":"Patrik","family":"Michel","sequence":"first","affiliation":[{"name":"From the Neurology Service (P.M., C.O., M.Ru., M.Re., G.N.), Service of Diagnostic and Interventional Radiology (P.M., R.M.), Division of Clinical Pharmacology (A.M.), Institute of Social and Preventive Medicine (M.F.), and Service of Neuropsychology and Rehabilitation (A.C.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland; Department of Radiology, Division of Neuroradiology (M.W.), University of Virginia, Charlottesville, Va."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce\u0301line","family":"Odier","sequence":"additional","affiliation":[{"name":"From the Neurology Service (P.M., C.O., M.Ru., M.Re., G.N.), Service of Diagnostic and Interventional Radiology (P.M., R.M.), Division of Clinical Pharmacology (A.M.), Institute of Social and Preventive Medicine (M.F.), and Service of Neuropsychology and Rehabilitation (A.C.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland; Department of Radiology, Division of Neuroradiology (M.W.), University of Virginia, Charlottesville, Va."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Rutgers","sequence":"additional","affiliation":[{"name":"From the Neurology Service (P.M., C.O., M.Ru., M.Re., G.N.), Service of Diagnostic and Interventional Radiology (P.M., R.M.), Division of Clinical Pharmacology (A.M.), Institute of Social and Preventive Medicine (M.F.), and Service of Neuropsychology and Rehabilitation (A.C.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland; Department of Radiology, Division of Neuroradiology (M.W.), University of Virginia, Charlottesville, Va."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Reichhart","sequence":"additional","affiliation":[{"name":"From the Neurology Service (P.M., C.O., M.Ru., M.Re., G.N.), Service of Diagnostic and Interventional Radiology (P.M., R.M.), Division of Clinical Pharmacology (A.M.), Institute of Social and Preventive Medicine (M.F.), and Service of Neuropsychology and Rehabilitation (A.C.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland; Department of Radiology, Division of Neuroradiology (M.W.), University of Virginia, Charlottesville, Va."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Maeder","sequence":"additional","affiliation":[{"name":"From the Neurology Service (P.M., C.O., M.Ru., M.Re., G.N.), Service of Diagnostic and Interventional Radiology (P.M., R.M.), Division of Clinical Pharmacology (A.M.), Institute of Social and Preventive Medicine (M.F.), and Service of Neuropsychology and Rehabilitation (A.C.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland; Department of Radiology, Division of Neuroradiology (M.W.), University of Virginia, Charlottesville, Va."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Meuli","sequence":"additional","affiliation":[{"name":"From the Neurology Service (P.M., C.O., M.Ru., M.Re., G.N.), Service of Diagnostic and Interventional Radiology (P.M., R.M.), Division of Clinical Pharmacology (A.M.), Institute of Social and Preventive Medicine (M.F.), and Service of Neuropsychology and Rehabilitation (A.C.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland; Department of Radiology, Division of Neuroradiology (M.W.), University of Virginia, Charlottesville, Va."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Wintermark","sequence":"additional","affiliation":[{"name":"From the Neurology Service (P.M., C.O., M.Ru., M.Re., G.N.), Service of Diagnostic and Interventional Radiology (P.M., R.M.), Division of Clinical Pharmacology (A.M.), Institute of Social and Preventive Medicine (M.F.), and Service of Neuropsychology and Rehabilitation (A.C.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland; Department of Radiology, Division of Neuroradiology (M.W.), University of Virginia, Charlottesville, Va."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Maghraoui","sequence":"additional","affiliation":[{"name":"From the Neurology Service (P.M., C.O., M.Ru., M.Re., G.N.), Service of Diagnostic and Interventional Radiology (P.M., R.M.), Division of Clinical Pharmacology (A.M.), Institute of Social and Preventive Medicine (M.F.), and Service of Neuropsychology and Rehabilitation (A.C.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland; Department of Radiology, Division of Neuroradiology (M.W.), University of Virginia, Charlottesville, Va."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Faouzi","sequence":"additional","affiliation":[{"name":"From the Neurology Service (P.M., C.O., M.Ru., M.Re., G.N.), Service of Diagnostic and Interventional Radiology (P.M., R.M.), Division of Clinical Pharmacology (A.M.), Institute of Social and Preventive Medicine (M.F.), and Service of Neuropsychology and Rehabilitation (A.C.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland; Department of Radiology, Division of Neuroradiology (M.W.), University of Virginia, Charlottesville, Va."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Croquelois","sequence":"additional","affiliation":[{"name":"From the Neurology Service (P.M., C.O., M.Ru., M.Re., G.N.), Service of Diagnostic and Interventional Radiology (P.M., R.M.), Division of Clinical Pharmacology (A.M.), Institute of Social and Preventive Medicine (M.F.), and Service of Neuropsychology and Rehabilitation (A.C.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland; Department of Radiology, Division of Neuroradiology (M.W.), University of Virginia, Charlottesville, Va."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Ntaios","sequence":"additional","affiliation":[{"name":"From the Neurology Service (P.M., C.O., M.Ru., M.Re., G.N.), Service of Diagnostic and Interventional Radiology (P.M., R.M.), Division of Clinical Pharmacology (A.M.), Institute of Social and Preventive Medicine (M.F.), and Service of Neuropsychology and Rehabilitation (A.C.), Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland; Department of Radiology, Division of Neuroradiology (M.W.), University of Virginia, Charlottesville, Va."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.17.2.3961825"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.19.9.3413804"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000103123"},{"key":"e_1_3_3_4_2","first-page":"541","volume":"54","year":"1976","unstructured":"Hatano S. Experience from a multicentre stroke register: a preliminary report. Bull World Health Organ. 1976; 54: 541\u2013553.","journal-title":"Bull World Health Organ"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.6.5.564"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20617"},{"key":"e_1_3_3_8_2","first-page":"28","volume":"27","year":"2009","unstructured":"Hennerici MG. Rationale and design of the Prevention of Cerebrovascular and Cardiovascular Events of Ischemic Origin with Terutroban in Patients with a History of Ischemic Stroke or Transient Ischemic Attack PERFORM Study. 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Thrombolyse de l\u2019attaque c\u00e9r\u00e9brale isch\u00e9mique: recommandations actualis\u00e9es. Forum M\u00e9dical Suisse. 2006; 6: 225\u2013228.","journal-title":"Forum M\u00e9dical Suisse"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.21.2003"},{"key":"e_1_3_3_18_2","unstructured":"Marler JR Jones PW and Emr M eds. Proceedings of a National Symposium on Rapid Identification and Treatment of Acute Stroke. Bethesda MD National Institute of Neurological Disorders and Stroke NIH Publication No. 97\u20134239 1997."},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.27.10.1770"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1159\/000047697"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000093241"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000016042"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000155989"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/str.32.11.2559"},{"key":"e_1_3_3_25_2","first-page":"327","volume":"10","year":"2007","unstructured":"Ghandehari K, Izadi-Mood Z. Khorasan stroke registry: analysis of 1392 stroke patients. 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Swiss Med Wkly. 2009; 139 (5\u20136): 65\u201369.","journal-title":"Swiss Med Wkly"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.108.192218"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.11.3160"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.106.25.3143"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.110.596189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:20:30Z","timestamp":1715610030000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.110.596189"}},"subtitle":["Design and Baseline Analysis of an Ischemic Stroke Registry Including Acute Multimodal Imaging"],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1161\/STROKEAHA.110.596189"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.110.596189","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"2010-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-08-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-10-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}