{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:48:13Z","timestamp":1791082093564,"version":"4.1.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose\u2014<\/jats:title>\n                    <jats:p>The long-standing concept that delayed cerebral infarction after aneurysmal subarachnoid hemorrhage results exclusively from large artery vasospasm recently has been challenged. We used data from the CONSCIOUS-1 trial to determine the relationship between angiographic vasospasm and cerebral infarction after subarachnoid hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u2014<\/jats:title>\n                    <jats:p>We performed a post hoc exploratory analysis of the CONSCIOUS-1 data. All patients underwent catheter angiography before treatment and 9\u00b12 days after subarachnoid hemorrhage. CT was performed before and after aneurysm treatment, and 6 weeks after subarachnoid hemorrhage. Angiograms and CT scans were assessed by centralized blinded review. Angiographic vasospasm was classified as none\/mild (0%\u201333% decrease in arterial diameter), moderate (34%\u201366%), or severe (\u226567%). Infarctions were categorized as secondary to angiographic vasospasm, other, or unknown causes. Logistic regression was conducted to determine factors associated with infarction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results\u2014<\/jats:title>\n                    <jats:p>Complete data were available for 381 of 413 patients (92%). Angiographic vasospasm was none\/mild in 209 (55%) patients, moderate in 118 (31%), and severe in 54 (14%). Infarcts developed in 6 (3%) of 209 with no\/mild, 12 (10%) of 118 patients with moderate, and 25 (46%) of 54 patients with severe vasospasm. Multivariate analysis found a strong association between angiographic vasospasm and cerebral infarction (OR, 9.3; 95% CI, 3.7\u201323.4). The significant association persisted after adjusting for admission neurological grade and aneurysm size. Method of aneurysm treatment was not associated with a significant difference in frequency of infarction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions\u2014<\/jats:title>\n                    <jats:p>A strong association exists between angiographic vasospasm and cerebral infarction. Efforts directed at further reducing angiographic vasospasm are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/strokeaha.110.597005","type":"journal-article","created":{"date-parts":[[2011,2,24]],"date-time":"2011-02-24T23:22:30Z","timestamp":1298589750000},"page":"919-923","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":244,"title":["Angiographic Vasospasm Is Strongly Correlated With Cerebral Infarction After Subarachnoid Hemorrhage"],"prefix":"10.1161","volume":"42","author":[{"given":"R. Webster","family":"Crowley","sequence":"first","affiliation":[{"name":"From the Departments of Neurological Surgery (A.S.D., R.W.C., R.M., N.F.K.) and Radiology (A.S.D.), University of Virginia School of Medicine, Charlottesville, VA; Columbia University (S.M.), New York, NY; University Hospitals of Geneva (D.R.), Geneva, Switzerland; University of Mannheim (P.S.), Mannheim, Germany; University of Frankfurt (S.W.), Frankfurt, Germany; Ospedale Civile Maggiore di Verona (A.P.), Verona, Italy; Division of Neurosurgery (D.I., R.L.M.), St. Michael's Hospital, Labatt Family..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Medel","sequence":"additional","affiliation":[{"name":"From the Departments of Neurological Surgery (A.S.D., R.W.C., R.M., N.F.K.) and Radiology (A.S.D.), University of Virginia School of Medicine, Charlottesville, VA; Columbia University (S.M.), New York, NY; University Hospitals of Geneva (D.R.), Geneva, Switzerland; University of Mannheim (P.S.), Mannheim, Germany; University of Frankfurt (S.W.), Frankfurt, Germany; Ospedale Civile Maggiore di Verona (A.P.), Verona, Italy; Division of Neurosurgery (D.I., R.L.M.), St. Michael's Hospital, Labatt Family..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron S.","family":"Dumont","sequence":"additional","affiliation":[{"name":"From the Departments of Neurological Surgery (A.S.D., R.W.C., R.M., N.F.K.) and Radiology (A.S.D.), University of Virginia School of Medicine, Charlottesville, VA; Columbia University (S.M.), New York, NY; University Hospitals of Geneva (D.R.), Geneva, Switzerland; University of Mannheim (P.S.), Mannheim, Germany; University of Frankfurt (S.W.), Frankfurt, Germany; Ospedale Civile Maggiore di Verona (A.P.), Verona, Italy; Division of Neurosurgery (D.I., R.L.M.), St. Michael's Hospital, Labatt Family..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Ilodigwe","sequence":"additional","affiliation":[{"name":"From the Departments of Neurological Surgery (A.S.D., R.W.C., R.M., N.F.K.) and Radiology (A.S.D.), University of Virginia School of Medicine, Charlottesville, VA; Columbia University (S.M.), New York, NY; University Hospitals of Geneva (D.R.), Geneva, Switzerland; University of Mannheim (P.S.), Mannheim, Germany; University of Frankfurt (S.W.), Frankfurt, Germany; Ospedale Civile Maggiore di Verona (A.P.), Verona, Italy; Division of Neurosurgery (D.I., R.L.M.), St. Michael's Hospital, Labatt Family..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal F.","family":"Kassell","sequence":"additional","affiliation":[{"name":"From the Departments of Neurological Surgery (A.S.D., R.W.C., R.M., N.F.K.) and Radiology (A.S.D.), University of Virginia School of Medicine, Charlottesville, VA; Columbia University (S.M.), New York, NY; University Hospitals of Geneva (D.R.), Geneva, Switzerland; University of Mannheim (P.S.), Mannheim, Germany; University of Frankfurt (S.W.), Frankfurt, Germany; Ospedale Civile Maggiore di Verona (A.P.), Verona, Italy; Division of Neurosurgery (D.I., R.L.M.), St. Michael's Hospital, Labatt Family..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan A.","family":"Mayer","sequence":"additional","affiliation":[{"name":"From the Departments of Neurological Surgery (A.S.D., R.W.C., R.M., N.F.K.) and Radiology (A.S.D.), University of Virginia School of Medicine, Charlottesville, VA; Columbia University (S.M.), New York, NY; University Hospitals of Geneva (D.R.), Geneva, Switzerland; University of Mannheim (P.S.), Mannheim, Germany; University of Frankfurt (S.W.), Frankfurt, Germany; Ospedale Civile Maggiore di Verona (A.P.), Verona, Italy; Division of Neurosurgery (D.I., R.L.M.), St. Michael's Hospital, Labatt Family..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ruefenacht","sequence":"additional","affiliation":[{"name":"From the Departments of Neurological Surgery (A.S.D., R.W.C., R.M., N.F.K.) and Radiology (A.S.D.), University of Virginia School of Medicine, Charlottesville, VA; Columbia University (S.M.), New York, NY; University Hospitals of Geneva (D.R.), Geneva, Switzerland; University of Mannheim (P.S.), Mannheim, Germany; University of Frankfurt (S.W.), Frankfurt, Germany; Ospedale Civile Maggiore di Verona (A.P.), Verona, Italy; Division of Neurosurgery (D.I., R.L.M.), St. Michael's Hospital, Labatt Family..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schmiedek","sequence":"additional","affiliation":[{"name":"From the Departments of Neurological Surgery (A.S.D., R.W.C., R.M., N.F.K.) and Radiology (A.S.D.), University of Virginia School of Medicine, Charlottesville, VA; Columbia University (S.M.), New York, NY; University Hospitals of Geneva (D.R.), Geneva, Switzerland; University of Mannheim (P.S.), Mannheim, Germany; University of Frankfurt (S.W.), Frankfurt, Germany; Ospedale Civile Maggiore di Verona (A.P.), Verona, Italy; Division of Neurosurgery (D.I., R.L.M.), St. Michael's Hospital, Labatt Family..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Weidauer","sequence":"additional","affiliation":[{"name":"From the Departments of Neurological Surgery (A.S.D., R.W.C., R.M., N.F.K.) and Radiology (A.S.D.), University of Virginia School of Medicine, Charlottesville, VA; Columbia University (S.M.), New York, NY; University Hospitals of Geneva (D.R.), Geneva, Switzerland; University of Mannheim (P.S.), Mannheim, Germany; University of Frankfurt (S.W.), Frankfurt, Germany; Ospedale Civile Maggiore di Verona (A.P.), Verona, Italy; Division of Neurosurgery (D.I., R.L.M.), St. Michael's Hospital, Labatt Family..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Pasqualin","sequence":"additional","affiliation":[{"name":"From the Departments of Neurological Surgery (A.S.D., R.W.C., R.M., N.F.K.) and Radiology (A.S.D.), University of Virginia School of Medicine, Charlottesville, VA; Columbia University (S.M.), New York, NY; University Hospitals of Geneva (D.R.), Geneva, Switzerland; University of Mannheim (P.S.), Mannheim, Germany; University of Frankfurt (S.W.), Frankfurt, Germany; Ospedale Civile Maggiore di Verona (A.P.), Verona, Italy; Division of Neurosurgery (D.I., R.L.M.), St. Michael's Hospital, Labatt Family..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Loch","family":"Macdonald","sequence":"additional","affiliation":[{"name":"From the Departments of Neurological Surgery (A.S.D., R.W.C., R.M., N.F.K.) and Radiology (A.S.D.), University of Virginia School of Medicine, Charlottesville, VA; Columbia University (S.M.), New York, NY; University Hospitals of Geneva (D.R.), Geneva, Switzerland; University of Mannheim (P.S.), Mannheim, Germany; University of Frankfurt (S.W.), Frankfurt, Germany; Ospedale Civile Maggiore di Verona (A.P.), Verona, Italy; Division of Neurosurgery (D.I., R.L.M.), St. Michael's Hospital, Labatt Family..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1990.73.1.0018"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.484360"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01476281"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-198111000-00003"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1179\/174313209X393564"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-009-0575-y"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.10.1586"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000133132.76983.8e"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000255396.23280.31"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000343543.43180.9C"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.106.477976"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000227519.27569.45"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp102"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.108.519942"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200112000-00010"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-004-0349-6"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000163090.59350.5a"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3171\/JNS.2008.109.12.1052"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5306-0"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.21.365"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000349209.69973.88"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-007-0294-1"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.109.547331"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000035748.91128.C2"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.110.597005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:36:29Z","timestamp":1715596589000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.110.597005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1161\/STROKEAHA.110.597005"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.110.597005","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725859147.793510599","asserted-by":"object"}]},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4]]},"assertion":[{"value":"2010-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-10-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-02-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}