{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:21:39Z","timestamp":1778523699371,"version":"3.51.4"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Symptomatic carotid artery plaque ulceration is associated with distinct plaque components such as a large lipid-rich necrotic core (LR-NC) in ischemic stroke patients with a \u226550% carotid stenosis. We evaluated the associations between carotid artery plaque ulceration and plaque characteristics in ischemic stroke patients with \u226550% stenosis, as well as in those with a low degree of stenosis (0% to 49%).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>Consecutive patients (n=346) with symptoms in the anterior circulation were evaluated with multidetector CT angiography (MDCTA) for the presence of atherosclerotic plaque, degree of stenosis, and plaque ulceration in the symptomatic carotid artery. Plaque volume and plaque component proportions of LR-NC, fibrous tissue, and calcification were measured. The associations between plaque ulceration and plaque characteristics were analyzed using logistic regression.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>Atherosclerotic plaque was present in 185 patients. Plaque ulcerations were present in 38 (21%) patients, of which half had a low degree stenosis (0% to 49%). Plaque volume was significantly larger in ulcerated plaques. After adjustment for age, sex, and degree of stenosis, LR-NC proportion was strongly associated with plaque ulceration (odds ratio, 2.21; 95% CI, 1.49 to 3.27), whereas calcification proportion was inversely associated with plaque ulceration (odds ratio, 0.60; 95% CI, 0.40 to 0.89). These associations remained significant in patients with a low degree stenosis (0% to 49%).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion\u2014<\/jats:title>\n            <jats:p>Plaque volume, degree of stenosis, and LR-NC proportion evaluated noninvasively with MDCTA are associated with carotid artery plaque ulceration, even in patients with a low degree stenosis (0% to 49%). Plaque volume and composition analysis with MDCTA may identify rupture prone plaques and improve risk stratification in ischemic stroke patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.110.597369","type":"journal-article","created":{"date-parts":[[2010,12,24]],"date-time":"2010-12-24T04:39:32Z","timestamp":1293165572000},"page":"367-372","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["Association Between Carotid Artery Plaque Ulceration and Plaque Composition Evaluated With Multidetector CT Angiography"],"prefix":"10.1161","volume":"42","author":[{"given":"Philip J.","family":"Homburg","sequence":"first","affiliation":[{"name":"From the Departments of Radiology (P.J.H., S.R., M.J.v.G., Q.J.A.v.d.B., A.v.d.L.), Epidemiology (Q.J.A.v.d.B.), Medical Informatics (W.J.N.), and Neurology (D.W.J.D.), Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; and Faculty of Applied Sciences (W.J.N.), Delft University of Technology, Delft, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sietske","family":"Rozie","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (P.J.H., S.R., M.J.v.G., Q.J.A.v.d.B., A.v.d.L.), Epidemiology (Q.J.A.v.d.B.), Medical Informatics (W.J.N.), and Neurology (D.W.J.D.), Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; and Faculty of Applied Sciences (W.J.N.), Delft University of Technology, Delft, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjon J.","family":"van Gils","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (P.J.H., S.R., M.J.v.G., Q.J.A.v.d.B., A.v.d.L.), Epidemiology (Q.J.A.v.d.B.), Medical Informatics (W.J.N.), and Neurology (D.W.J.D.), Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; and Faculty of Applied Sciences (W.J.N.), Delft University of Technology, Delft, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quirijn J.A.","family":"van den Bouwhuijsen","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (P.J.H., S.R., M.J.v.G., Q.J.A.v.d.B., A.v.d.L.), Epidemiology (Q.J.A.v.d.B.), Medical Informatics (W.J.N.), and Neurology (D.W.J.D.), Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; and Faculty of Applied Sciences (W.J.N.), Delft University of Technology, Delft, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiro J.","family":"Niessen","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (P.J.H., S.R., M.J.v.G., Q.J.A.v.d.B., A.v.d.L.), Epidemiology (Q.J.A.v.d.B.), Medical Informatics (W.J.N.), and Neurology (D.W.J.D.), Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; and Faculty of Applied Sciences (W.J.N.), Delft University of Technology, Delft, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diederik W.J.","family":"Dippel","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (P.J.H., S.R., M.J.v.G., Q.J.A.v.d.B., A.v.d.L.), Epidemiology (Q.J.A.v.d.B.), Medical Informatics (W.J.N.), and Neurology (D.W.J.D.), Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; and Faculty of Applied Sciences (W.J.N.), Delft University of Technology, Delft, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aad","family":"van der Lugt","sequence":"additional","affiliation":[{"name":"From the Departments of Radiology (P.J.H., S.R., M.J.v.G., Q.J.A.v.d.B., A.v.d.L.), Epidemiology (Q.J.A.v.d.B.), Medical Informatics (W.J.N.), and Neurology (D.W.J.D.), Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; and Faculty of Applied Sciences (W.J.N.), Delft University of Technology, Delft, The Netherlands."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.2.304"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.3.615"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000144307.82502.32"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1842"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10091157"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.108.538439"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.109.576256"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2372040653"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-005-2712-2"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.6.711"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000240518.90124.57"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0950"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000204638.91099.91"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2522080792"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000191391.71614.51"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21424"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.17.2171"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc2601.091704"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.184.1.01840295"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.3.774"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000239895.00373.E4"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.579474"},{"key":"e_1_3_3_24_2","first-page":"676","article-title":"Carotid artery atheroma: comparison of preoperative B-mode ultrasound appearance with carotid endarterectomy specimen pathology","volume":"29","author":"Gray-Weale AC","year":"1988","unstructured":"Gray-Weale AC, Graham JC, Burnett JR, Byrne K, Lusby RJ . Carotid artery atheroma: comparison of preoperative B-mode ultrasound appearance with carotid endarterectomy specimen pathology. J Cardiovasc Surg. 1988;29:676\u2013681.","journal-title":"J Cardiovasc Surg"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000141426.63959.cc"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.502906"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.108.526434"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0486"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.110.597369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T13:56:31Z","timestamp":1715608591000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.110.597369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["10.1161\/STROKEAHA.110.597369"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.110.597369","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2]]},"assertion":[{"value":"2010-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-09-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2010-12-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}