{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:17:54Z","timestamp":1791155874927,"version":"4.1.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>The DRAGON score, which includes clinical and computed tomographic scan parameters, showed a high specificity to predict 3-month outcome in patients with acute ischemic stroke treated by intravenous tissue plasminogen activator. We adapted the score for patients undergoing MRI as the first-line diagnostic tool.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>We reviewed patients with consecutive anterior circulation ischemic stroke treated \u22644.5 hour by intravenous tissue plasminogen activator between 2003 and 2012 in our center, where MRI is systematically implemented as first-line diagnostic work-up. We derived the MRI-DRAGON score keeping all clinical parameters of computed tomography-DRAGON (age, initial National Institutes of Health Stroke Scale and glucose level, prestroke handicap, onset to treatment time), and considering the following radiological variables: proximal middle cerebral artery occlusion on MR angiography instead of hyperdense middle cerebral artery sign, and diffusion-weighted imaging Alberta Stroke Program Early Computed Tomography Score (DWI ASPECTS) \u22645 instead of early infarct signs on computed tomography. Poor 3-month outcome was defined as modified Rankin scale &gt;2. We calculated c-statistics as a measure of predictive ability and performed an internal cross-validation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>Two hundred twenty-eight patients were included. Poor outcome was observed in 98 (43%) patients and was significantly associated with all parameters of the MRI-DRAGON score in multivariate analysis, except for onset to treatment time (nonsignificant trend). The c-statistic was 0.83 (95% confidence interval, 0.78\u20130.88) for poor outcome prediction. All patients with a MRI-DRAGON score \u22642 (n=22) had a good outcome, whereas all patients with a score \u22658 (n=11) had a poor outcome.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>The MRI-DRAGON score is a simple tool to predict 3-month outcome in acute stroke patients screened by MRI then treated by intravenous tissue plasminogen activator and may help for therapeutic decision.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.111.000127","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T03:06:16Z","timestamp":1363143976000},"page":"1323-1328","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":50,"title":["Magnetic Resonance Imaging-DRAGON Score"],"prefix":"10.1161","volume":"44","author":[{"given":"Guillaume","family":"Turc","sequence":"first","affiliation":[{"name":"From the Service de Neurologie (G.T., M.A., D.C., C.L., A.M.T., J.-L.M., J.-C.B., E.T.) and Service de Neuroradiologie (O.N., J.-F.M., C.O.), Sorbonne Paris Cit\u00e9, INSERM UMR S894, H\u00f4pital Sainte-Anne, Universit\u00e9 Paris Descartes, Paris, France; and Service de Neurologie, INSERM U919, GIP Cyceron, CHU C\u00f4te de Nacre, Universit\u00e9 de Caen Basse Normandie, Caen, France (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Apoil","sequence":"additional","affiliation":[{"name":"From the Service de Neurologie (G.T., M.A., D.C., C.L., A.M.T., J.-L.M., J.-C.B., E.T.) and Service de Neuroradiologie (O.N., J.-F.M., C.O.), Sorbonne Paris Cit\u00e9, INSERM UMR S894, H\u00f4pital Sainte-Anne, Universit\u00e9 Paris Descartes, Paris, France; and Service de Neurologie, INSERM U919, GIP Cyceron, CHU C\u00f4te de Nacre, Universit\u00e9 de Caen Basse Normandie, Caen, France (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Naggara","sequence":"additional","affiliation":[{"name":"From the Service de Neurologie (G.T., M.A., D.C., C.L., A.M.T., J.-L.M., J.-C.B., E.T.) and Service de Neuroradiologie (O.N., J.-F.M., C.O.), Sorbonne Paris Cit\u00e9, INSERM UMR S894, H\u00f4pital Sainte-Anne, Universit\u00e9 Paris Descartes, Paris, France; and Service de Neurologie, INSERM U919, GIP Cyceron, CHU C\u00f4te de Nacre, Universit\u00e9 de Caen Basse Normandie, Caen, France (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Calvet","sequence":"additional","affiliation":[{"name":"From the Service de Neurologie (G.T., M.A., D.C., C.L., A.M.T., J.-L.M., J.-C.B., E.T.) and Service de Neuroradiologie (O.N., J.-F.M., C.O.), Sorbonne Paris Cit\u00e9, INSERM UMR S894, H\u00f4pital Sainte-Anne, Universit\u00e9 Paris Descartes, Paris, France; and Service de Neurologie, INSERM U919, GIP Cyceron, CHU C\u00f4te de Nacre, Universit\u00e9 de Caen Basse Normandie, Caen, France (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Lamy","sequence":"additional","affiliation":[{"name":"From the Service de Neurologie (G.T., M.A., D.C., C.L., A.M.T., J.-L.M., J.-C.B., E.T.) and Service de Neuroradiologie (O.N., J.-F.M., C.O.), Sorbonne Paris Cit\u00e9, INSERM UMR S894, H\u00f4pital Sainte-Anne, Universit\u00e9 Paris Descartes, Paris, France; and Service de Neurologie, INSERM U919, GIP Cyceron, CHU C\u00f4te de Nacre, Universit\u00e9 de Caen Basse Normandie, Caen, France (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina M.","family":"Tataru","sequence":"additional","affiliation":[{"name":"From the Service de Neurologie (G.T., M.A., D.C., C.L., A.M.T., J.-L.M., J.-C.B., E.T.) and Service de Neuroradiologie (O.N., J.-F.M., C.O.), Sorbonne Paris Cit\u00e9, INSERM UMR S894, H\u00f4pital Sainte-Anne, Universit\u00e9 Paris Descartes, Paris, France; and Service de Neurologie, INSERM U919, GIP Cyceron, CHU C\u00f4te de Nacre, Universit\u00e9 de Caen Basse Normandie, Caen, France (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"M\u00e9der","sequence":"additional","affiliation":[{"name":"From the Service de Neurologie (G.T., M.A., D.C., C.L., A.M.T., J.-L.M., J.-C.B., E.T.) and Service de Neuroradiologie (O.N., J.-F.M., C.O.), Sorbonne Paris Cit\u00e9, INSERM UMR S894, H\u00f4pital Sainte-Anne, Universit\u00e9 Paris Descartes, Paris, France; and Service de Neurologie, INSERM U919, GIP Cyceron, CHU C\u00f4te de Nacre, Universit\u00e9 de Caen Basse Normandie, Caen, France (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Mas","sequence":"additional","affiliation":[{"name":"From the Service de Neurologie (G.T., M.A., D.C., C.L., A.M.T., J.-L.M., J.-C.B., E.T.) and Service de Neuroradiologie (O.N., J.-F.M., C.O.), Sorbonne Paris Cit\u00e9, INSERM UMR S894, H\u00f4pital Sainte-Anne, Universit\u00e9 Paris Descartes, Paris, France; and Service de Neurologie, INSERM U919, GIP Cyceron, CHU C\u00f4te de Nacre, Universit\u00e9 de Caen Basse Normandie, Caen, France (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Baron","sequence":"additional","affiliation":[{"name":"From the Service de Neurologie (G.T., M.A., D.C., C.L., A.M.T., J.-L.M., J.-C.B., E.T.) and Service de Neuroradiologie (O.N., J.-F.M., C.O.), Sorbonne Paris Cit\u00e9, INSERM UMR S894, H\u00f4pital Sainte-Anne, Universit\u00e9 Paris Descartes, Paris, France; and Service de Neurologie, INSERM U919, GIP Cyceron, CHU C\u00f4te de Nacre, Universit\u00e9 de Caen Basse Normandie, Caen, France (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Oppenheim","sequence":"additional","affiliation":[{"name":"From the Service de Neurologie (G.T., M.A., D.C., C.L., A.M.T., J.-L.M., J.-C.B., E.T.) and Service de Neuroradiologie (O.N., J.-F.M., C.O.), Sorbonne Paris Cit\u00e9, INSERM UMR S894, H\u00f4pital Sainte-Anne, Universit\u00e9 Paris Descartes, Paris, France; and Service de Neurologie, INSERM U919, GIP Cyceron, CHU C\u00f4te de Nacre, Universit\u00e9 de Caen Basse Normandie, Caen, France (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Touz\u00e9","sequence":"additional","affiliation":[{"name":"From the Service de Neurologie (G.T., M.A., D.C., C.L., A.M.T., J.-L.M., J.-C.B., E.T.) and Service de Neuroradiologie (O.N., J.-F.M., C.O.), Sorbonne Paris Cit\u00e9, INSERM UMR S894, H\u00f4pital Sainte-Anne, Universit\u00e9 Paris Descartes, Paris, France; and Service de Neurologie, INSERM U919, GIP Cyceron, CHU C\u00f4te de Nacre, Universit\u00e9 de Caen Basse Normandie, Caen, France (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000258112.14918.24"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61339-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2011.127"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804656"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60491-6"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318245d2a9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02237-6"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2004.059261"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5787-x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.111.639708"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2010.00487.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.108.533067"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181eccf78"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000181116.15426.58"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000327690"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.06.010"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000237070.80133.1d"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000330297.58334.dd"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.111.646265"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000249054.96644.c6"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318259e221"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5406-x"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.111.000127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:32:54Z","timestamp":1715610774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.111.000127"}},"subtitle":["3-Month Outcome Prediction After Intravenous Thrombolysis for Anterior Circulation Stroke"],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1161\/STROKEAHA.111.000127"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.111.000127","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"2012-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}