{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:11:42Z","timestamp":1774343502894,"version":"3.50.1"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>To describe parkinsonism as a clinical manifestation of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>\n              We report 5 patients carrying the R1006C mutation in the exon 19 of\n              <jats:italic>NOTCH3<\/jats:italic>\n              gene. All cases presented late onset, slowly progressive parkinsonism, not responsive to l-dopa. We performed brain MRI and\n              <jats:sup>123<\/jats:sup>\n              I-FP-CIT SPECT in all and in 3 additional patients carrying the same mutation but without parkinsonism. Four patients with parkinsonism underwent myocardial\n              <jats:sup>123<\/jats:sup>\n              I-meta-iodobenzylguanidine scintigraphy.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>\n              In all patients, brain MRI showed widespread ischemic lesions in the periventricular white matter, the internal and external capsules, the basal ganglia, and thalami.\n              <jats:sup>123<\/jats:sup>\n              I-FP-CIT SPECT showed symmetrical or asymmetrical reduction of tracer uptake in the putamen, with inconstant caudate involvement. Myocardial\n              <jats:sup>123<\/jats:sup>\n              I-meta-iodobenzylguanidine scintigraphy resulted normal. Nigrostriatal denervation was also demonstrated in 2 patients without parkinsonism.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>In cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, parkinsonism may be a not rare, late onset manifestation. The clinical picture, the lack of response to dopaminergic treatment, and MRI findings suggest a vascular parkinsonism, which may be preceded by a protracted presymptomatic phase.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.111.000458","type":"journal-article","created":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T05:58:00Z","timestamp":1360907880000},"page":"1147-1149","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Parkinsonism is a Late, Not Rare, Feature of CADASIL"],"prefix":"10.1161","volume":"44","author":[{"given":"Michele","family":"Ragno","sequence":"first","affiliation":[{"name":"From the Neurology Division (M.R., G.C., F.D.M., M.S.), Nuclear Medicine Department (A.B.), and Molecular Medicine Section (L.P., S.S.), Mazzoni Hospital, Ascoli Piceno, Italy; Department of Radiology, Italian National Research Center of Aging, Ancona, Italy (A.M.); and Department of Neurological Sciences, Federico II University, Naples, Italy (A.D.R., G.D.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Berbellini","sequence":"additional","affiliation":[{"name":"From the Neurology Division (M.R., G.C., F.D.M., M.S.), Nuclear Medicine Department (A.B.), and Molecular Medicine Section (L.P., S.S.), Mazzoni Hospital, Ascoli Piceno, Italy; Department of Radiology, Italian National Research Center of Aging, Ancona, Italy (A.M.); and Department of Neurological Sciences, Federico II University, Naples, Italy (A.D.R., G.D.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Cacchi\u00f2","sequence":"additional","affiliation":[{"name":"From the Neurology Division (M.R., G.C., F.D.M., M.S.), Nuclear Medicine Department (A.B.), and Molecular Medicine Section (L.P., S.S.), Mazzoni Hospital, Ascoli Piceno, Italy; Department of Radiology, Italian National Research Center of Aging, Ancona, Italy (A.M.); and Department of Neurological Sciences, Federico II University, Naples, Italy (A.D.R., G.D.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Manca","sequence":"additional","affiliation":[{"name":"From the Neurology Division (M.R., G.C., F.D.M., M.S.), Nuclear Medicine Department (A.B.), and Molecular Medicine Section (L.P., S.S.), Mazzoni Hospital, Ascoli Piceno, Italy; Department of Radiology, Italian National Research Center of Aging, Ancona, Italy (A.M.); and Department of Neurological Sciences, Federico II University, Naples, Italy (A.D.R., G.D.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Di Marzio","sequence":"additional","affiliation":[{"name":"From the Neurology Division (M.R., G.C., F.D.M., M.S.), Nuclear Medicine Department (A.B.), and Molecular Medicine Section (L.P., S.S.), Mazzoni Hospital, Ascoli Piceno, Italy; Department of Radiology, Italian National Research Center of Aging, Ancona, Italy (A.M.); and Department of Neurological Sciences, Federico II University, Naples, Italy (A.D.R., G.D.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Pianese","sequence":"additional","affiliation":[{"name":"From the Neurology Division (M.R., G.C., F.D.M., M.S.), Nuclear Medicine Department (A.B.), and Molecular Medicine Section (L.P., S.S.), Mazzoni Hospital, Ascoli Piceno, Italy; Department of Radiology, Italian National Research Center of Aging, Ancona, Italy (A.M.); and Department of Neurological Sciences, Federico II University, Naples, Italy (A.D.R., G.D.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"De Rosa","sequence":"additional","affiliation":[{"name":"From the Neurology Division (M.R., G.C., F.D.M., M.S.), Nuclear Medicine Department (A.B.), and Molecular Medicine Section (L.P., S.S.), Mazzoni Hospital, Ascoli Piceno, Italy; Department of Radiology, Italian National Research Center of Aging, Ancona, Italy (A.M.); and Department of Neurological Sciences, Federico II University, Naples, Italy (A.D.R., G.D.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Silvestri","sequence":"additional","affiliation":[{"name":"From the Neurology Division (M.R., G.C., F.D.M., M.S.), Nuclear Medicine Department (A.B.), and Molecular Medicine Section (L.P., S.S.), Mazzoni Hospital, Ascoli Piceno, Italy; Department of Radiology, Italian National Research Center of Aging, Ancona, Italy (A.M.); and Department of Neurological Sciences, Federico II University, Naples, Italy (A.D.R., G.D.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Scarcella","sequence":"additional","affiliation":[{"name":"From the Neurology Division (M.R., G.C., F.D.M., M.S.), Nuclear Medicine Department (A.B.), and Molecular Medicine Section (L.P., S.S.), Mazzoni Hospital, Ascoli Piceno, Italy; Department of Radiology, Italian National Research Center of Aging, Ancona, Italy (A.M.); and Department of Neurological Sciences, Federico II University, Naples, Italy (A.D.R., G.D.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"De Michele","sequence":"additional","affiliation":[{"name":"From the Neurology Division (M.R., G.C., F.D.M., M.S.), Nuclear Medicine Department (A.B.), and Molecular Medicine Section (L.P., S.S.), Mazzoni Hospital, Ascoli Piceno, Italy; Department of Radiology, Italian National Research Center of Aging, Ancona, Italy (A.M.); and Department of Neurological Sciences, Federico II University, Naples, Italy (A.D.R., G.D.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/383707a0"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440506"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(02)00146-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-007-0529-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-5983-3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.06.087"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20083"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.086959"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.111.000458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:18:22Z","timestamp":1715609902000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.111.000458"}},"subtitle":["A Study on Italian Patients Carrying the R1006C Mutation"],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1161\/STROKEAHA.111.000458"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.111.000458","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"2012-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-12-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}