{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T12:15:14Z","timestamp":1792844114896,"version":"4.5.0"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>The accuracy of diffusion-weighted imaging (DWI) for the diagnosis of acute cerebral ischemia among patients with suspected ischemic stroke arriving to an emergency room has not been studied in depth.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>DWI was performed in 712 patients with acute or subacute focal symptoms that suggested an acute ischemic stroke (AIS), 609 of them with AIS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>DWI demonstrated a sensitivity of 90% and specificity of 97%, a positive likelihood ratio of 31 and a negative likelihood ratio of 0.1 for detecting AIS. The overall accuracy was 95%. Of those patients who demonstrated abnormal DWI studies, 99.5% were AIS patients, and of those patients with normal DWI studies 63% were stroke mimics.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>DWI is accurate in detecting AIS in unselected patients with suspected AIS; a negative study should alert for nonischemic conditions.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.111.000527","type":"journal-article","created":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T13:56:12Z","timestamp":1362146172000},"page":"1169-1171","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Accuracy of Diffusion-Weighted Imaging in the Diagnosis of Stroke in Patients With Suspected Cerebral Infarct"],"prefix":"10.1161","volume":"44","author":[{"given":"Alejandro M.","family":"Brunser","sequence":"first","affiliation":[{"name":"From the Cerebrovascular Program, Neurology Service, Department of Internal Medicine Cl\u00ednica Alemana de Santiago, Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile (A.M.B., A.H., S.I., V.D., P.M., D.C., V.O., M.V., P.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold","family":"Hoppe","sequence":"additional","affiliation":[{"name":"From the Cerebrovascular Program, Neurology Service, Department of Internal Medicine Cl\u00ednica Alemana de Santiago, Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile (A.M.B., A.H., S.I., V.D., P.M., D.C., V.O., M.V., P.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Illanes","sequence":"additional","affiliation":[{"name":"From the Cerebrovascular Program, Neurology Service, Department of Internal Medicine Cl\u00ednica Alemana de Santiago, Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile (A.M.B., A.H., S.I., V.D., P.M., D.C., V.O., M.V., P.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"From the Cerebrovascular Program, Neurology Service, Department of Internal Medicine Cl\u00ednica Alemana de Santiago, Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile (A.M.B., A.H., S.I., V.D., P.M., D.C., V.O., M.V., P.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"From the Cerebrovascular Program, Neurology Service, Department of Internal Medicine Cl\u00ednica Alemana de Santiago, Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile (A.M.B., A.H., S.I., V.D., P.M., D.C., V.O., M.V., P.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"C\u00e1rcamo","sequence":"additional","affiliation":[{"name":"From the Cerebrovascular Program, Neurology Service, Department of Internal Medicine Cl\u00ednica Alemana de Santiago, Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile (A.M.B., A.H., S.I., V.D., P.M., D.C., V.O., M.V., P.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Olavarria","sequence":"additional","affiliation":[{"name":"From the Cerebrovascular Program, Neurology Service, Department of Internal Medicine Cl\u00ednica Alemana de Santiago, Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile (A.M.B., A.H., S.I., V.D., P.M., D.C., V.O., M.V., P.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"From the Cerebrovascular Program, Neurology Service, Department of Internal Medicine Cl\u00ednica Alemana de Santiago, Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile (A.M.B., A.H., S.I., V.D., P.M., D.C., V.O., M.V., P.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Lavados","sequence":"additional","affiliation":[{"name":"From the Cerebrovascular Program, Neurology Service, Department of Internal Medicine Cl\u00ednica Alemana de Santiago, Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile (A.M.B., A.H., S.I., V.D., P.M., D.C., V.O., M.V., P.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","first-page":"1061","article-title":"Clinical experience with diffusion-weighted MR in patients with acute stroke.","volume":"19","author":"L\u00f6vblad KO","year":"1998","unstructured":"L\u00f6vblad KO, Laubach HJ, Baird AE, Curtin F, Schlaug G, Edelman RR, et al.. Clinical experience with diffusion-weighted MR in patients with acute stroke. AJNR Am J Neuroradiol. 1998;19:1061\u20131066.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410410505"},{"key":"e_1_3_3_4_2","first-page":"1434","article-title":"False-negative diffusion-weighted MR findings in acute ischemic stroke.","volume":"21","author":"Oppenheim C","year":"2000","unstructured":"Oppenheim C, Stanescu R, Dormont D, Crozier S, Marro B, Samson Y, et al.. False-negative diffusion-weighted MR findings in acute ischemic stroke. AJNR Am J Neuroradiol. 2000;21:1434\u20131440.","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.1.133"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.497453"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.210.1.r99ja02155"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.9.1783"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000319068"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.110.609339"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000339676"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.111.000527","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T14:18:10Z","timestamp":1715609890000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.111.000527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1161\/STROKEAHA.111.000527"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.111.000527","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"2012-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-12-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}