{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:31:26Z","timestamp":1790033486604,"version":"4.0.1"},"reference-count":85,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>A major challenge to effective treatment after stroke is the restoration of neuronal function. In recent years, cell-based therapies for stroke have been explored in experimental animal models, and the results have suggested behavioral improvements. However, the anatomic targets of a cell-based stroke therapy and the relationship of cell grafts to post stroke reorganization are poorly understood, which results in difficulties defining strategies for neuronal substitution. Given that stroke causes a variety of secondary changes at locations beyond the infarct lesion, overcoming these difficulties is even more important.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Summary of Review<\/jats:title>\n            <jats:p>We describe which brain structures and cell types are candidates for substitution and how new neuronal functionality could be implemented in a damaged brain by capitalizing on current concepts of post stroke plasticity.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.111.613422","type":"journal-article","created":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T15:17:41Z","timestamp":1310138261000},"page":"2342-2350","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["Restoring Neuronal Function After Stroke by Cell Replacement"],"prefix":"10.1161","volume":"42","author":[{"given":"Marcel","family":"Dihn\u00e9","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Heinrich-Heine University, D\u00fcsseldorf, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Hartung","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Heinrich-Heine University, D\u00fcsseldorf, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fcdiger J.","family":"Seitz","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Heinrich-Heine University, D\u00fcsseldorf, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60694-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70025-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/1073858402239592"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.01.005"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01401-0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22315"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000039406.64644.cb"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(09)17532-5"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.06.026"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.11.029"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2252"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2719"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-02-01463.1995"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(94)90158-9"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2010.05.003"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.05.009"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01922-6"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2735"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/35067562"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4249-08.2009"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3256-05.2005"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn754"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.11.2135"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.01.004"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.65"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90517-J"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1643-04.2004"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.107.507426"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi132"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20459"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3834-03.2004"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2005.09.016"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1080\/16501970500314350"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-14-06062.2002"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0097"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0038"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1495"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0654"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl261"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001644"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4318-09.2010"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature07287"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.09.002"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5128-10.2011"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.019"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1151526"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010209107"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1004584107"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09805"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09798"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.10.003"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8346-1"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.108.533208"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.3171\/FOC\/2008\/24\/3-4\/E14"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00208-9"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2005.14.595"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404474101"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20246"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1326"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.11.084"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.219"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt751"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-04-03039.1995"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5428.754"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5269.1791"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.26.14809"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05028"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-10-93"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.05.020"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06599.x"},{"key":"e_1_3_2_72_2","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0413"},{"key":"e_1_3_2_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp290"},{"key":"e_1_3_2_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/334701a0"},{"key":"e_1_3_2_75_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.9.1794"},{"key":"e_1_3_2_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/80430"},{"key":"e_1_3_2_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/386671a0"},{"key":"e_1_3_2_78_2","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-6-54"},{"key":"e_1_3_2_79_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704091104"},{"key":"e_1_3_2_80_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10691"},{"key":"e_1_3_2_81_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420622"},{"key":"e_1_3_2_82_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2005.14.722"},{"key":"e_1_3_2_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.08.092"},{"key":"e_1_3_2_84_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm306"},{"key":"e_1_3_2_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2004.09.020"},{"key":"e_1_3_2_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.07.010"}],"container-title":["Stroke"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/STROKEAHA.111.613422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T13:59:29Z","timestamp":1715608769000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/STROKEAHA.111.613422"}},"subtitle":["Anatomic and Functional Considerations"],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":85,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.1161\/STROKEAHA.111.613422"],"URL":"https:\/\/doi.org\/10.1161\/strokeaha.111.613422","relation":{},"ISSN":["0039-2499","1524-4628"],"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8]]},"assertion":[{"value":"2011-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-04-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-07-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}