{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:33:01Z","timestamp":1790764381363,"version":"4.1.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Stroke"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:sec>\n            <jats:title>Background and Purpose\u2014<\/jats:title>\n            <jats:p>Treatment with the iron chelator, deferoxamine mesylate (DFO), improves neurological recovery in animal models of intracerebral hemorrhage (ICH). We aimed to evaluate the feasibility, safety, and tolerability of varying dose-tiers of DFO in patients with spontaneous ICH, and to determine the maximum tolerated dose to be adopted in future efficacy studies.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\u2014<\/jats:title>\n            <jats:p>This was a multicenter, phase-I, dose-finding study using the Continual Reassessment Method. DFO was administered by intravenous infusion for 3 consecutive days, starting within 18 hours of ICH onset. Subjects underwent repeated clinical assessments through 90 days, and computed tomography neuroimaging pre- and post-drug-administration.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results\u2014<\/jats:title>\n            <jats:p>Twenty subjects were enrolled onto 5 dose tiers, starting with 7 mg\/kg per day and ending with 62 mg\/kg per day as the maximum tolerated dose. Median age was 68 years (range, 50\u201390); 60% were men; and median Glasgow Coma Scale and National Institutes of Health Stroke Scale scores on admission were 15 (5\u201315) and 9 (0\u201339), respectively. ICH location was lobar in 40%, deep in 50%, and brain stem in 10%; intraventricular hemorrhage was present in 15%. DFO was discontinued because of adverse events in 2 subjects (10%). Six subjects (30%) experienced 12 serious adverse events, none of which were drug-related. DFO infusions were associated with mild blood-pressure-lowering effects. Fifty percent of patients had modified Rankin scale scores \u22642, and 39% had modified Rankin scale scores of 4 to 6 on day 90; 15% died.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions\u2014<\/jats:title>\n            <jats:p>Consecutive daily infusions of DFO after ICH are feasible, well-tolerated, and not associated with excessive serious adverse events or mortality. Our findings lay the groundwork for future studies to evaluate the efficacy of DFO in ICH.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/strokeaha.111.617589","type":"journal-article","created":{"date-parts":[[2011,8,26]],"date-time":"2011-08-26T02:59:47Z","timestamp":1314327587000},"page":"3067-3074","update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":126,"title":["Safety and Tolerability of Deferoxamine Mesylate in Patients With Acute Intracerebral Hemorrhage"],"prefix":"10.1161","volume":"42","author":[{"given":"Magdy","family":"Selim","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Stroke Division (M.S., G.S.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Medicine, Division of Biostatistics and Epidemiology (S.Y., B.W., Y.P.), Medical University of South Carolina, Charleston, SC; Departments of Emergency Medicine and Neurology (J.N.G., S.G.), Massachusetts General Hospital, Boston, MA; Cerebrovascular Center (J.G.), The Cleveland Clinic Foundation, Cleveland, OH; Stroke Program and Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Yeatts","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Division (M.S., G.S.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Medicine, Division of Biostatistics and Epidemiology (S.Y., B.W., Y.P.), Medical University of South Carolina, Charleston, SC; Departments of Emergency Medicine and Neurology (J.N.G., S.G.), Massachusetts General Hospital, Boston, MA; Cerebrovascular Center (J.G.), The Cleveland Clinic Foundation, Cleveland, OH; Stroke Program and Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua N.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Division (M.S., G.S.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Medicine, Division of Biostatistics and Epidemiology (S.Y., B.W., Y.P.), Medical University of South Carolina, Charleston, SC; Departments of Emergency Medicine and Neurology (J.N.G., S.G.), Massachusetts General Hospital, Boston, MA; Cerebrovascular Center (J.G.), The Cleveland Clinic Foundation, Cleveland, OH; Stroke Program and Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao","family":"Gomes","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Division (M.S., G.S.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Medicine, Division of Biostatistics and Epidemiology (S.Y., B.W., Y.P.), Medical University of South Carolina, Charleston, SC; Departments of Emergency Medicine and Neurology (J.N.G., S.G.), Massachusetts General Hospital, Boston, MA; Cerebrovascular Center (J.G.), The Cleveland Clinic Foundation, Cleveland, OH; Stroke Program and Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Greenberg","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Division (M.S., G.S.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Medicine, Division of Biostatistics and Epidemiology (S.Y., B.W., Y.P.), Medical University of South Carolina, Charleston, SC; Departments of Emergency Medicine and Neurology (J.N.G., S.G.), Massachusetts General Hospital, Boston, MA; Cerebrovascular Center (J.G.), The Cleveland Clinic Foundation, Cleveland, OH; Stroke Program and Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis B.","family":"Morgenstern","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Division (M.S., G.S.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Medicine, Division of Biostatistics and Epidemiology (S.Y., B.W., Y.P.), Medical University of South Carolina, Charleston, SC; Departments of Emergency Medicine and Neurology (J.N.G., S.G.), Massachusetts General Hospital, Boston, MA; Cerebrovascular Center (J.G.), The Cleveland Clinic Foundation, Cleveland, OH; Stroke Program and Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gottfried","family":"Schlaug","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Division (M.S., G.S.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Medicine, Division of Biostatistics and Epidemiology (S.Y., B.W., Y.P.), Medical University of South Carolina, Charleston, SC; Departments of Emergency Medicine and Neurology (J.N.G., S.G.), Massachusetts General Hospital, Boston, MA; Cerebrovascular Center (J.G.), The Cleveland Clinic Foundation, Cleveland, OH; Stroke Program and Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Torbey","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Division (M.S., G.S.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Medicine, Division of Biostatistics and Epidemiology (S.Y., B.W., Y.P.), Medical University of South Carolina, Charleston, SC; Departments of Emergency Medicine and Neurology (J.N.G., S.G.), Massachusetts General Hospital, Boston, MA; Cerebrovascular Center (J.G.), The Cleveland Clinic Foundation, Cleveland, OH; Stroke Program and Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie","family":"Waldman","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Division (M.S., G.S.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Medicine, Division of Biostatistics and Epidemiology (S.Y., B.W., Y.P.), Medical University of South Carolina, Charleston, SC; Departments of Emergency Medicine and Neurology (J.N.G., S.G.), Massachusetts General Hospital, Boston, MA; Cerebrovascular Center (J.G.), The Cleveland Clinic Foundation, Cleveland, OH; Stroke Program and Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Xi","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Division (M.S., G.S.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Medicine, Division of Biostatistics and Epidemiology (S.Y., B.W., Y.P.), Medical University of South Carolina, Charleston, SC; Departments of Emergency Medicine and Neurology (J.N.G., S.G.), Massachusetts General Hospital, Boston, MA; Cerebrovascular Center (J.G.), The Cleveland Clinic Foundation, Cleveland, OH; Stroke Program and Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Palesch","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Stroke Division (M.S., G.S.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Medicine, Division of Biostatistics and Epidemiology (S.Y., B.W., Y.P.), Medical University of South Carolina, Charleston, SC; Departments of Emergency Medicine and Neurology (J.N.G., S.G.), Massachusetts General Hospital, Boston, MA; Cerebrovascular Center (J.G.), The Cleveland Clinic Foundation, Cleveland, OH; Stroke Program and Department of..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Deferoxamine Mesylate in Intracerebral Hemorrhage Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10633"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.96.2.0287"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.0000103140.52838.45"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600578"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1996.13.223"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.01.036"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.04.018"},{"key":"e_1_3_4_9_2","first-page":"82","article-title":"Toxicity of iron and hydrogen peroxide: the Fenton reaction","author":"Winterbourn CC","year":"1995","unstructured":"Winterbourn CC. 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